ICD-10-CM (2010)/CHAPTER 4

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ICD-10-CM TABULAR LIST of DISEASES and INJURIES  (2010) 
CHAPTER 4 - Endocrine, nutritional and metabolic diseases (E00-E90)

Contents

Endocrine, nutritional and metabolic diseases (E00-E90)[edit]

All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.


Excludes1: transitory endocrine and metabolic disorders specific to newborn (P70-P74)
This chapter contains the following blocks:
E00-E07 Disorders of thyroid gland
E08-E13 Diabetes mellitus
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
E20-E35 Disorders of other endocrine glands
E36 Intraoperative complications of endocrine system
E40-E46 Malnutrition
E50-E64 Other nutritional deficiencies
E65-E68 Overweight, obesity and other hyperalimentation
E70-E88 Metabolic disorders
E89 Postprocedural endocrine and metabolic complications and disorders, not elsewhere classified

Disorders of thyroid gland (E00-E07)[edit]

E00 Congenital iodine-deficiency syndrome[edit]

Use additional code (F70-F79) to identify associated mental retardation.
Excludes1: subclinical iodine-deficiency hypothyroidism (E02)
E00.0 Congenital iodine-deficiency syndrome, neurological type
Endemic cretinism, neurological type
E00.1 Congenital iodine-deficiency syndrome, myxedematous type
Endemic hypothyroid cretinism
Endemic cretinism, myxedematous type
E00.2 Congenital iodine-deficiency syndrome, mixed type
Endemic cretinism, mixed type
E00.9 Congenital iodine-deficiency syndrome, unspecified
Congenital iodine-deficiency hypothyroidism NOS
Endemic cretinism NOS

E01 Iodine-deficiency related thyroid disorders and allied conditions[edit]

Excludes1: congenital iodine-deficiency syndrome (E00.-)
subclinical iodine-deficiency hypothyroidism (E02)
E01.0 Iodine-deficiency related diffuse (endemic) goiter
E01.1 Iodine-deficiency related multinodular (endemic) goiter
Iodine-deficiency related nodular goiter
E01.2 Iodine-deficiency related (endemic) goiter, unspecified
Endemic goiter NOS
E01.8 Other iodine-deficiency related thyroid disorders and allied conditions
Acquired iodine-deficiency hypothyroidism NOS

E02 Subclinical iodine-deficiency hypothyroidism[edit]

E03 Other hypothyroidism[edit]

Excludes1: iodine-deficiency related hypothyroidism (E00-E02)
postprocedural hypothyroidism (E89.0)
E03.0 Congenital hypothyroidism with diffuse goiter
Congenital parenchymatous goiter (nontoxic)
Congenital goiter (nontoxic) NOS
Excludes1: transitory congenital goiter with normal function (P72.0)
E03.1 Congenital hypothyroidism without goiter
Aplasia of thyroid (with myxedema)
Congenital atrophy of thyroid
Congenital hypothyroidism NOS
E03.2 Hypothyroidism due to medicaments and other exogenous substances
Code first (T36-T65) to identify drug or substance
E03.3 Postinfectious hypothyroidism
E03.4 Atrophy of thyroid (acquired)
Excludes1: congenital atrophy of thyroid (E03.1)
E03.5 Myxedema coma
E03.8 Other specified hypothyroidism
E03.9 Hypothyroidism, unspecified
Myxedema NOS

E04 Other nontoxic goiter[edit]

Excludes1: congenital goiter (NOS) (diffuse) (parenchymatous) (E03.0)
iodine-deficiency related goiter (E00-E02)
E04.0 Nontoxic diffuse goiter
Diffuse (colloid) nontoxic goiter
Simple nontoxic goiter
E04.1 Nontoxic single thyroid nodule
Colloid nodule (cystic) (thyroid)
Nontoxic uninodular goiter
Thyroid (cystic) nodule NOS
E04.2 Nontoxic multinodular goiter
Cystic goiter NOS
Multinodular (cystic) goiter NOS
E04.8 Other specified nontoxic goiter
E04.9 Nontoxic goiter, unspecified
Goiter NOS
Nodular goiter (nontoxic) NOS

E05 Thyrotoxicosis [hyperthyroidism][edit]

Excludes1: chronic thyroiditis with transient thyrotoxicosis (E06.2)
neonatal thyrotoxicosis (P72.1)
E05.0 Thyrotoxicosis with diffuse goiter
Exophthalmic or toxic goiter NOS
Graves' disease
Toxic diffuse goiter
E05.00 Thyrotoxicosis with diffuse goiter without thyrotoxic crisis or storm
E05.01 Thyrotoxicosis with diffuse goiter with thyrotoxic crisis or storm
E05.1 Thyrotoxicosis with toxic single thyroid nodule
Thyrotoxicosis with toxic uninodular goiter
E05.10 Thyrotoxicosis with toxic single thyroid nodule without thyrotoxic crisis or storm
E05.11 Thyrotoxicosis with toxic single thyroid nodule with thyrotoxic crisis or storm
E05.2 Thyrotoxicosis with toxic multinodular goiter
Toxic nodular goiter NOS
E05.20 Thyrotoxicosis with toxic multinodular goiter without thyrotoxic crisis or storm
E05.21 Thyrotoxicosis with toxic multinodular goiter with thyrotoxic crisis or storm
E05.3 Thyrotoxicosis from ectopic thyroid tissue
E05.30 Thyrotoxicosis from ectopic thyroid tissue without thyrotoxic crisis or storm
E05.31 Thyrotoxicosis from ectopic thyroid tissue with thyrotoxic crisis or storm
E05.4 Thyrotoxicosis factitia
E05.40 Thyrotoxicosis factitia without thyrotoxic crisis or storm
E05.41 Thyrotoxicosis factitia with thyrotoxic crisis or storm
E05.8 Other thyrotoxicosis
Overproduction of thyroid-stimulating hormone
E05.80 Other thyrotoxicosis without thyrotoxic crisis or storm
E05.81 Other thyrotoxicosis with thyrotoxic crisis or storm
E05.9 Thyrotoxicosis, unspecified
Hyperthyroidism NOS
E05.90 Thyrotoxicosis, unspecified without thyrotoxic crisis or storm
E05.91 Thyrotoxicosis, unspecified with thyrotoxic crisis or storm

E06 Thyroiditis[edit]

Excludes1: postpartum thyroiditis (O90.5)
E06.0 Acute thyroiditis
Abscess of thyroid
Pyogenic thyroiditis
Suppurative thyroiditis
Use additional code (B95-B97) to identify infectious agent.
E06.1 Subacute thyroiditis
de Quervain thyroiditis
Giant-cell thyroiditis
Granulomatous thyroiditis
Nonsuppurative thyroiditis
Viral thyroiditis
Excludes1: autoimmune thyroiditis (E06.3)
E06.2 Chronic thyroiditis with transient thyrotoxicosis
Excludes1: autoimmune thyroiditis (E06.3)
E06.3 Autoimmune thyroiditis
Hashimoto's thyroiditis
Hashitoxicosis (transient)
Lymphadenoid goiter
Lymphocytic thyroiditis
Struma lymphomatosa
E06.4 Drug-induced thyroiditis
Code first (T36-T50) to identify drug
E06.5 Other chronic thyroiditis
Chronic fibrous thyroiditis
Chronic thyroiditis NOS
Ligneous thyroiditis
Riedel thyroiditis
E06.9 Thyroiditis, unspecified

E07 Other disorders of thyroid[edit]

E07.0 Hypersecretion of calcitonin
C-cell hyperplasia of thyroid
Hypersecretion of thyrocalcitonin
E07.1 Dyshormogenetic goiter
Familial dyshormogenetic goiter
Pendred's syndrome
Excludes1: transitory congenital goiter with normal function (P72.0)
E07.8 Other specified disorders of thyroid
E07.81 Sick-euthyroid syndrome
Euthyroid sick-syndrome
E07.89 Other specified disorders of thyroid
Abnormality of thyroid-binding globulin
Hemorrhage of thyroid
Infarction of thyroid
E07.9 Disorder of thyroid, unspecified

Diabetes mellitus (E08-E13)[edit]

E08 Diabetes mellitus due to underlying condition[edit]

Code first the underlying condition, such as:
Congenital rubella (P35.0)
Cushing's syndrome (E24.-)
Cystic fibrosis (E84.-)
Malignant neoplasm (C00-C96)
Malnutrition (E40-E46)
Pancreatitis and other diseases of the pancreas (K85-K86.-)
Use additional code to identify any insulin use (Z79.4)
Excludes1: drug or chemical induced diabetes mellitus (E09.-)
gestational diabetes (O24.4-)
neonatal diabetes mellitus (P70.2)
type 1 diabetes mellitus (E10.-)
type 2 diabetes mellitus (E11.-)
E08.0 Diabetes mellitus due to underlying condition with hyperosmolarity
E08.00 Diabetes mellitus due to underlying condition with hyperosmolarity without nonketotic hyperglycemic-hyperosmolar coma (NKHHC)
E08.01 Diabetes mellitus due to underlying condition with hyperosmolarity with coma
E08.1 Diabetes mellitus due to underlying condition with ketoacidosis
E08.10 Diabetes mellitus due to underlying condition with ketoacidosis without coma
E08.11 Diabetes mellitus due to underlying condition with ketoacidosis with coma
E08.2 Diabetes mellitus due to underlying condition with kidney complications
E08.21 Diabetes mellitus due to underlying condition with diabetic nephropathy
Diabetes mellitus due to underlying condition with intercapillary glomerulosclerosis
Diabetes mellitus due to underlying condition with intracapillary glomerulonephrosis
Diabetes mellitus due to underlying condition with Kimmelstiel-Wilson disease
E08.22 Diabetes mellitus due to underlying condition with diabetic chronic kidney disease
Diabetes mellitus due to underlying condition with chronic kidney disease due to conditions classified to .21 and .22
Use additional code to identify stage of chronic kidney disease (N18.1-N18.6)
E08.29 Diabetes mellitus due to underlying condition with other diabetic kidney complication
Renal tubular degeneration in diabetes mellitus due to underlying condition
E08.3 Diabetes mellitus due to underlying condition with ophthalmic complications
E08.31 Diabetes mellitus due to underlying condition with unspecified diabetic retinopathy
E08.311 Diabetes mellitus due to underlying condition with unspecified diabetic retinopathy with macular edema
E08.319 Diabetes mellitus due to underlying condition with unspecified diabetic retinopathy without macular edema
E08.32 Diabetes mellitus due to underlying condition with mild nonproliferative diabetic retinopathy
Diabetes mellitus due to underlying condition with nonproliferative diabetic retinopathy NOS
E08.321 Diabetes mellitus due to underlying condition with mild nonproliferative diabetic retinopathy with macular edema
E08.329 Diabetes mellitus due to underlying condition with mild nonproliferative diabetic retinopathy without macular edema
E08.33 Diabetes mellitus due to underlying condition with moderate nonproliferative diabetic retinopathy
E08.331 Diabetes mellitus due to underlying condition with moderate nonproliferative diabetic retinopathy with macular edema
E08.339 Diabetes mellitus due to underlying condition with moderate nonproliferative diabetic retinopathy without macular edema
E08.34 Diabetes mellitus due to underlying condition with severe nonproliferative diabetic retinopathy
E08.341 Diabetes mellitus due to underlying condition with severe nonproliferative diabetic retinopathy with macular edema
E08.349 Diabetes mellitus due to underlying condition with severe nonproliferative diabetic retinopathy without macular edema
E08.35 Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy
E08.351 Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy with macular edema
E08.359 Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy without macular edema
E08.36 Diabetes mellitus due to underlying condition with diabetic cataract
E08.39 Diabetes mellitus due to underlying condition with other diabetic ophthalmic complication
E08.4 Diabetes mellitus due to underlying condition with neurological complications
E08.40 Diabetes mellitus due to underlying condition with diabetic neuropathy, unspecified
E08.41 Diabetes mellitus due to underlying condition with diabetic mononeuropathy
E08.42 Diabetes mellitus due to underlying condition with diabetic polyneuropathy
Diabetes mellitus due to underlying condition with diabetic neuralgia
E08.43 Diabetes mellitus due to underlying condition with diabetic autonomic (poly)neuropathy
Diabetes mellitus due to underlying condition with diabetic gastroparesis
E08.44 Diabetes mellitus due to underlying condition with diabetic amyotrophy
E08.49 Diabetes mellitus due to underlying condition with other diabetic neurological complication
E08.5 Diabetes mellitus due to underlying condition with circulatory complications
E08.51 Diabetes mellitus due to underlying condition with diabetic peripheral angiopathy without gangrene
E08.52 Diabetes mellitus due to underlying condition with diabetic peripheral angiopathy with gangrene
Diabetes mellitus due to underlying condition with diabetic gangrene
E08.59 Diabetes mellitus due to underlying condition with other circulatory complications
E08.6 Diabetes mellitus due to underlying condition with other specified complications
E08.61 Diabetes mellitus due to underlying condition with diabetic arthropathy
E08.610 Diabetes mellitus due to underlying condition with diabetic neuropathic arthropathy
Diabetes mellitus due to underlying condition with Charcot's joints
E08.618 Diabetes mellitus due to underlying condition with other diabetic arthropathy
E08.62 Diabetes mellitus due to underlying condition with skin complications
E08.620 Diabetes mellitus due to underlying condition with diabetic dermatitis
Diabetes mellitus due to underlying condition with diabetic necrobiosis lipoidica
E08.621 Diabetes mellitus due to underlying condition with foot ulcer
Use additional code to identify site of ulcer (L97.4-, L97.5-)
E08.622 Diabetes mellitus due to underlying condition with other skin ulcer
Use additional code to identify site of ulcer (L97.1-L97.9, L98.41-L98.49)
E08.628 Diabetes mellitus due to underlying condition with other skin complications
E08.63 Diabetes mellitus due to underlying condition with oral complications
E08.630 Diabetes mellitus due to underlying condition with periodontal disease
E08.638 Diabetes mellitus due to underlying condition with other oral complications
E08.64 Diabetes mellitus due to underlying condition with hypoglycemia
E08.641 Diabetes mellitus due to underlying condition with hypoglycemia with coma
E08.649 Diabetes mellitus due to underlying condition with hypoglycemia without coma
E08.65 Diabetes mellitus due to underlying condition with hyperglycemia
E08.69 Diabetes mellitus due to underlying condition with other specified complication
Use additional code to identify complication
E08.8 Diabetes mellitus due to underlying condition with unspecified complications
E08.9 Diabetes mellitus due to underlying condition without complications

E09 Drug or chemical induced diabetes mellitus[edit]

Code first (T36-T65) to identify drug or chemical
Use additional code to identify any insulin use (Z79.4)
Excludes1: diabetes mellitus due to underlying condition (E08.-)
gestational diabetes (O24.4-)
neonatal diabetes mellitus (P70.2)
type 1 diabetes mellitus (E10.-)
type 2 diabetes mellitus (E11.-)
E09.0 Drug or chemical induced diabetes mellitus with hyperosmolarity
E09.00 Drug or chemical induced diabetes mellitus with hyperosmolarity without nonketotic hyperglycemic-hyperosmolar coma (NKHHC)
E09.01 Drug or chemical induced diabetes mellitus with hyperosmolarity with coma
E09.1 Drug or chemical induced diabetes mellitus with ketoacidosis
E09.10 Drug or chemical induced diabetes mellitus with ketoacidosis without coma
E09.11 Drug or chemical induced diabetes mellitus with ketoacidosis with coma
E09.2 Drug or chemical induced diabetes mellitus with kidney complications
E09.21 Drug or chemical induced diabetes mellitus with diabetic nephropathy
Drug or chemical induced diabetes mellitus with intercapillary glomerulosclerosis
Drug or chemical induced diabetes mellitus with intracapillary glomerulonephrosis
Drug or chemical induced diabetes mellitus with Kimmelstiel-Wilson disease
E09.22 Drug or chemical induced diabetes mellitus with diabetic chronic kidney disease
Drug or chemical induced diabetes mellitus with chronic kidney disease due to conditions classified to .21 and .22
Use additional code to identify stage of chronic kidney disease (N18.1-N18.6)
E09.29 Drug or chemical induced diabetes mellitus with other diabetic kidney complication
Drug or chemical induced diabetes mellitus with renal tubular degeneration
E09.3 Drug or chemical induced diabetes mellitus with ophthalmic complications
E09.31 Drug or chemical induced diabetes mellitus with unspecified diabetic retinopathy
E09.311 Drug or chemical induced diabetes mellitus with unspecified diabetic retinopathy with macular edema
E09.319 Drug or chemical induced diabetes mellitus with unspecified diabetic retinopathy without macular edema
E09.32 Drug or chemical induced diabetes mellitus with mild nonproliferative diabetic retinopathy
Drug or chemical induced diabetes mellitus with nonproliferative diabetic retinopathy NOS
E09.321 Drug or chemical induced diabetes mellitus with mild nonproliferative diabetic retinopathy with macular edema
E09.329 Drug or chemical induced diabetes mellitus with mild nonproliferative diabetic retinopathy without macular edema
E09.33 Drug or chemical induced diabetes mellitus with moderate nonproliferative diabetic retinopathy
E09.331 Drug or chemical induced diabetes mellitus with moderate nonproliferative diabetic retinopathy with macular edema
E09.339 Drug or chemical induced diabetes mellitus with moderate nonproliferative diabetic retinopathy without macular edema
E09.34 Drug or chemical induced diabetes mellitus with severe nonproliferative diabetic retinopathy
E09.341 Drug or chemical induced diabetes mellitus with severe nonproliferative diabetic retinopathy with macular edema
E09.349 Drug or chemical induced diabetes mellitus with severe nonproliferative diabetic retinopathy without macular edema
E09.35 Drug or chemical induced diabetes mellitus with proliferative diabetic retinopathy
E09.351 Drug or chemical induced diabetes mellitus with proliferative diabetic retinopathy with macular edema
E09.359 Drug or chemical induced diabetes mellitus with proliferative diabetic retinopathy without macular edema
E09.36 Drug or chemical induced diabetes mellitus with diabetic cataract
E09.39 Drug or chemical induced diabetes mellitus with other diabetic ophthalmic complication
E09.4 Drug or chemical induced diabetes mellitus with neurological complications
E09.40 Drug or chemical induced diabetes mellitus with neurological complications with diabetic neuropathy, unspecified
E09.41 Drug or chemical induced diabetes mellitus with neurological complications with diabetic mononeuropathy
E09.42 Drug or chemical induced diabetes mellitus with neurological complications with diabetic polyneuropathy
Drug or chemical induced diabetes mellitus with diabetic neuralgia
E09.43 Drug or chemical induced diabetes mellitus with neurological complications with diabetic autonomic (poly)neuropathy
Drug or chemical induced diabetes mellitus with diabetic gastroparesis
E09.44 Drug or chemical induced diabetes mellitus with neurological complications with diabetic amyotrophy
E09.49 Drug or chemical induced diabetes mellitus with neurological complications with other diabetic neurological complication
E09.5 Drug or chemical induced diabetes mellitus with circulatory complications
E09.51 Drug or chemical induced diabetes mellitus with diabetic peripheral angiopathy without gangrene
E09.52 Drug or chemical induced diabetes mellitus with diabetic peripheral angiopathy with gangrene
Drug or chemical induced diabetes mellitus with diabetic gangrene
E09.59 Drug or chemical induced diabetes mellitus with other circulatory complications
E09.6 Drug or chemical induced diabetes mellitus with other specified complications
E09.61 Drug or chemical induced diabetes mellitus with diabetic arthropathy
E09.610 Drug or chemical induced diabetes mellitus with diabetic neuropathic arthropathy
Drug or chemical induced diabetes mellitus with Charcot's joints
E09.618 Drug or chemical induced diabetes mellitus with other diabetic arthropathy
E09.62 Drug or chemical induced diabetes mellitus with skin complications
E09.620 Drug or chemical induced diabetes mellitus with diabetic dermatitis
Drug or chemical induced diabetes mellitus with diabetic necrobiosis lipoidica
E09.621 Drug or chemical induced diabetes mellitus with foot ulcer
Use additional code to identify site of ulcer (L97.4-, L97.5-)
E09.622 Drug or chemical induced diabetes mellitus with other skin ulcer
Use additional code to identify site of ulcer (L97.1-L97.9, L98.41-L98.49)
E09.628 Drug or chemical induced diabetes mellitus with other skin complications
E09.63 Drug or chemical induced diabetes mellitus with oral complications
E09.630 Drug or chemical induced diabetes mellitus with periodontal disease
E09.638 Drug or chemical induced diabetes mellitus with other oral complications
E09.64 Drug or chemical induced diabetes mellitus with hypoglycemia
E09.641 Drug or chemical induced diabetes mellitus with hypoglycemia with coma
E09.649 Drug or chemical induced diabetes mellitus with hypoglycemia without coma
E09.65 Drug or chemical induced diabetes mellitus with hyperglycemia
E09.69 Drug or chemical induced diabetes mellitus with other specified complication
Use additional code to identify complication
E09.8 Drug or chemical induced diabetes mellitus with unspecified complications
E09.9 Drug or chemical induced diabetes mellitus without complications

E10 Type 1 diabetes mellitus[edit]

Includes: brittle diabetes (mellitus)
diabetes (mellitus) due to autoimmune process
diabetes (mellitus) due to immune mediated pancreatic islet beta-cell destruction
idiopathic diabetes (mellitus)
juvenile onset diabetes (mellitus)
ketosis-prone diabetes (mellitus)
Excludes1: diabetes mellitus due to underlying condition (E08.-)
drug or chemical induced diabetes mellitus (E09.-)
gestational diabetes (O24.4-)
hyperglycemia NOS (R73.9)
neonatal diabetes mellitus (P70.2)
type 2 diabetes mellitus (E11.-)
E10.1 Type 1 diabetes mellitus with ketoacidosis
E10.10 Type 1 diabetes mellitus with ketoacidosis without coma
E10.11 Type 1 diabetes mellitus with ketoacidosis with coma
E10.2 Type 1 diabetes mellitus with kidney complications
E10.21 Type 1 diabetes mellitus with diabetic nephropathy
Type 1 diabetes mellitus with intercapillary glomerulosclerosis
Type 1 diabetes mellitus with intracapillary glomerulonephrosis
Type 1 diabetes mellitus with Kimmelstiel-Wilson disease
E10.22 Type 1 diabetes mellitus with diabetic chronic kidney disease
Type 1 diabetes mellitus with chronic kidney disease due to conditions classified to .21 and .22
Use additional code to identify stage of chronic kidney disease (N18.1-N18.6)
E10.29 Type 1 diabetes mellitus with other diabetic kidney complication
Type 1 diabetes mellitus with renal tubular degeneration
E10.3 Type 1 diabetes mellitus with ophthalmic complications
E10.31 Type 1 diabetes mellitus with unspecified diabetic retinopathy
E10.311 Type 1 diabetes mellitus with unspecified diabetic retinopathy with macular edema
E10.319 Type 1 diabetes mellitus with unspecified diabetic retinopathy without macular edema
E10.32 Type 1 diabetes mellitus with mild nonproliferative diabetic retinopathy
Type 1 diabetes mellitus with nonproliferative diabetic retinopathy NOS
E10.321 Type 1 diabetes mellitus with mild nonproliferative diabetic retinopathy with macular edema
E10.329 Type 1 diabetes mellitus with mild nonproliferative diabetic retinopathy without macular edema
E10.33 Type 1 diabetes mellitus with moderate nonproliferative diabetic retinopathy
E10.331 Type 1 diabetes mellitus with moderate nonproliferative diabetic retinopathy with macular edema
E10.339 Type 1 diabetes mellitus with moderate nonproliferative diabetic retinopathy without macular edema
E10.34 Type 1 diabetes mellitus with severe nonproliferative diabetic retinopathy
E10.341 Type 1 diabetes mellitus with severe nonproliferative diabetic retinopathy with macular edema
E10.349 Type 1 diabetes mellitus with severe nonproliferative diabetic retinopathy without macular edema
E10.35 Type 1 diabetes mellitus with proliferative diabetic retinopathy
E10.351 Type 1 diabetes mellitus with proliferative diabetic retinopathy with macular edema
E10.359 Type 1 diabetes mellitus with proliferative diabetic retinopathy without macular edema
E10.36 Type 1 diabetes mellitus with diabetic cataract
E10.39 Type 1 diabetes mellitus with other diabetic ophthalmic complication
E10.4 Type 1 diabetes mellitus with neurological complications
E10.40 Type 1 diabetes mellitus with diabetic neuropathy, unspecified
E10.41 Type 1 diabetes mellitus with diabetic mononeuropathy
E10.42 Type 1 diabetes mellitus with diabetic polyneuropathy
Type 1 diabetes mellitus with diabetic neuralgia
E10.43 Type 1 diabetes mellitus with diabetic autonomic (poly)neuropathy
Type 1 diabetes mellitus with diabetic gastroparesis
E10.44 Type 1 diabetes mellitus with diabetic amyotrophy
E10.49 Type 1 diabetes mellitus with other diabetic neurological complication
E10.5 Type 1 diabetes mellitus with circulatory complications
E10.51 Type 1 diabetes mellitus with diabetic peripheral angiopathy without gangrene
E10.52 Type 1 diabetes mellitus with diabetic peripheral angiopathy with gangrene
Type 1 diabetes mellitus with diabetic gangrene
E10.59 Type 1 diabetes mellitus with other circulatory complications
E10.6 Type 1 diabetes mellitus with other specified complications
E10.61 Type 1 diabetes mellitus with diabetic arthropathy
E10.610 Type 1 diabetes mellitus with diabetic neuropathic arthropathy
Type 1 diabetes mellitus with Charcot's joints
E10.618 Type 1 diabetes mellitus with other diabetic arthropathy
E10.62 Type 1 diabetes mellitus with skin complications
E10.620 Type 1 diabetes mellitus with diabetic dermatitis
Type 1 diabetes mellitus with diabetic necrobiosis lipoidica
E10.621 Type 1 diabetes mellitus with foot ulcer
Use additional code to identify site of ulcer (L97.4-, L97.5-)
E10.622 Type 1 diabetes mellitus with other skin ulcer
Use additional code to identify site of ulcer (L97.1-L97.9, L98.41-L98.49)
E10.628 Type 1 diabetes mellitus with other skin complications
E10.63 Type 1 diabetes mellitus with oral complications
E10.630 Type 1 diabetes mellitus with periodontal disease
E10.638 Type 1 diabetes mellitus with other oral complications
E10.64 Type 1 diabetes mellitus with hypoglycemia
E10.641 Type 1 diabetes mellitus with hypoglycemia with coma
E10.649 Type 1 diabetes mellitus with hypoglycemia without coma
E10.65 Type 1 diabetes mellitus with hyperglycemia
E10.69 Type 1 diabetes mellitus with other specified complication
Use additional code to identify complication
E10.8 Type 1 diabetes mellitus with unspecified complications
E10.9 Type 1 diabetes mellitus without complications

E11 Type 2 diabetes mellitus[edit]

Includes: diabetes (mellitus) due to insulin secretory defect
diabetes NOS
insulin resistant diabetes (mellitus)
Use additional code to identify any insulin use (Z79.4)
Excludes1: diabetes mellitus due to underlying condition (E08.-)
drug or chemical induced diabetes mellitus (E09.-)
gestational diabetes (O24.4-)
neonatal diabetes mellitus (P70.2)
type 1 diabetes mellitus (E10.-)
E11.0 Type 2 diabetes mellitus with hyperosmolarity
E11.00 Type 2 diabetes mellitus with hyperosmolarity without nonketotic hyperglycemic-hyperosmolar coma (NKHHC)
E11.01 Type 2 diabetes mellitus with hyperosmolarity with coma
E11.2 Type 2 diabetes mellitus with kidney complications
E11.21 Type 2 diabetes mellitus with diabetic nephropathy
Type 2 diabetes mellitus with intercapillary glomerulosclerosis
Type 2 diabetes mellitus with intracapillary glomerulonephrosis
Type 2 diabetes mellitus with Kimmelstiel-Wilson disease
E11.22 Type 2 diabetes mellitus with diabetic chronic kidney disease
Type 2 diabetes mellitus with chronic kidney disease due to conditions classified to .21 and .22
Use additional code to identify stage of chronic kidney disease (N18.1-N18.6)
E11.29 Type 2 diabetes mellitus with other diabetic kidney complication
Type 2 diabetes mellitus with renal tubular degeneration
E11.3 Type 2 diabetes mellitus with ophthalmic complications
E11.31 Type 2 diabetes mellitus with unspecified diabetic retinopathy
E11.311 Type 2 diabetes mellitus with unspecified diabetic retinopathy with macular edema
E11.319 Type 2 diabetes mellitus with unspecified diabetic retinopathy without macular edema
E11.32 Type 2 diabetes mellitus with mild nonproliferative diabetic retinopathy
Type 2 diabetes mellitus with nonproliferative diabetic retinopathy NOS
E11.321 Type 2 diabetes mellitus with mild nonproliferative diabetic retinopathy with macular edema
E11.329 Type 2 diabetes mellitus with mild nonproliferative diabetic retinopathy without macular edema
E11.33 Type 2 diabetes mellitus with moderate nonproliferative diabetic retinopathy
E11.331 Type 2 diabetes mellitus with moderate nonproliferative diabetic retinopathy with macular edema
E11.339 Type 2 diabetes mellitus with moderate nonproliferative diabetic retinopathy without macular edema
E11.34 Type 2 diabetes mellitus with severe nonproliferative diabetic retinopathy
E11.341 Type 2 diabetes mellitus with severe nonproliferative diabetic retinopathy with macular edema
E11.349 Type 2 diabetes mellitus with severe nonproliferative diabetic retinopathy without macular edema
E11.35 Type 2 diabetes mellitus with proliferative diabetic retinopathy
E11.351 Type 2 diabetes mellitus with proliferative diabetic retinopathy with macular edema
E11.359 Type 2 diabetes mellitus with proliferative diabetic retinopathy without macular edema
E11.36 Type 2 diabetes mellitus with diabetic cataract
E11.39 Type 2 diabetes mellitus with other diabetic ophthalmic complication
E11.4 Type 2 diabetes mellitus with neurological comp``lications
E11.40 Type 2 diabetes mellitus with diabetic neuropathy, unspecified
E11.41 Type 2 diabetes mellitus with diabetic mononeuropathy
E11.42 Type 2 diabetes mellitus with diabetic polyneuropathy
Type 2 diabetes mellitus with diabetic neuralgia
E11.43 Type 2 diabetes mellitus with diabetic autonomic (poly)neuropathy
Type 2 diabetes mellitus with diabetic gastroparesis
E11.44 Type 2 diabetes mellitus with diabetic amyotrophy
E11.49 Type 2 diabetes mellitus with other diabetic neurological complication
E11.5 Type 2 diabetes mellitus with circulatory complications
E11.51 Type 2 diabetes mellitus with diabetic peripheral angiopathy without gangrene
E11.52 Type 2 diabetes mellitus with diabetic peripheral angiopathy with gangrene
Type 2 diabetes mellitus with diabetic gangrene
E11.59 Type 2 diabetes mellitus with other circulatory complications
E11.6 Type 2 diabetes mellitus with other specified complications
E11.61 Type 2 diabetes mellitus with diabetic arthropathy
E11.610 Type 2 diabetes mellitus with diabetic neuropathic arthropathy
Type 2 diabetes mellitus with Charcot's joints
E11.618 Type 2 diabetes mellitus with other diabetic arthropathy
E11.62 Type 2 diabetes mellitus with skin complications
E11.620 Type 2 diabetes mellitus with diabetic dermatitis
Type 2 diabetes mellitus with diabetic necrobiosis lipoidica
E11.621 Type 2 diabetes mellitus with foot ulcer
Use additional code to identify site of ulcer (L97.4-, L97.5-)
E11.622 Type 2 diabetes mellitus with other skin ulcer
Use additional code to identify site of ulcer (L97.1-L97.9, L98.41-L98.49)
E11.628 Type 2 diabetes mellitus with other skin complications
E11.63 Type 2 diabetes mellitus with oral complications
E11.630 Type 2 diabetes mellitus with periodontal disease
E11.638 Type 2 diabetes mellitus with other oral complications
E11.64 Type 2 diabetes mellitus with hypoglycemia
E11.641 Type 2 diabetes mellitus with hypoglycemia with coma
E11.649 Type 2 diabetes mellitus with hypoglycemia without coma
E11.65 Type 2 diabetes mellitus with hyperglycemia
E11.69 Type 2 diabetes mellitus with other specified complication
Use additional code to identify complication
E11.8 Type 2 diabetes mellitus with unspecified complications
E11.9 Type 2 diabetes mellitus without complications

E13 Other specified diabetes mellitus[edit]

Includes: diabetes mellitus due to genetic defects of beta-cell function
diabetes mellitus due to genetic defects in insulin action
Use additional code to identify any insulin use (Z79.4)
Excludes1: diabetes (mellitus) due to autoimmune process (E10.-)
diabetes (mellitus) due to immune mediated pancreatic islet beta-cell destruction (E10.-)
diabetes mellitus due to underlying condition (E08.-)
drug or chemical induced diabetes mellitus (E09.-)
gestational diabetes (O24.44)
neonatal diabetes mellitus (P70.2)
type 2 diabetes mellitus (E11.-)
E13.0 Other specified diabetes mellitus with hyperosmolarity
E13.00 Other specified diabetes mellitus with hyperosmolarity without nonketotic hyperglycemic-hyperosmolar coma (NKHHC)
E13.01 Other specified diabetes mellitus with hyperosmolarity with coma
E13.1 Other specified diabetes mellitus with ketoacidosis
E13.10 Other specified diabetes mellitus with ketoacidosis without coma
E13.11 Other specified diabetes mellitus with ketoacidosis with coma
E13.2 Other specified diabetes mellitus with kidney complications
E13.21 Other specified diabetes mellitus with diabetic nephropathy
Other specified diabetes mellitus with intercapillary glomerulosclerosis
Other specified diabetes mellitus with intracapillary glomerulonephrosis
Other specified diabetes mellitus with Kimmelstiel-Wilson disease
E13.22 Other specified diabetes mellitus with diabetic chronic kidney disease
Other specified diabetes mellitus with chronic kidney disease due to conditions classified to .21 and .22
Use additional code to identify stage of chronic kidney disease (N18.1-N18.6)
E13.29 Other specified diabetes mellitus with other diabetic kidney complication
Other specified diabetes mellitus with renal tubular degeneration
E13.3 Other specified diabetes mellitus with ophthalmic complications
E13.31 Other specified diabetes mellitus with unspecified diabetic retinopathy
E13.311 Other specified diabetes mellitus with unspecified diabetic retinopathy with macular edema
E13.319 Other specified diabetes mellitus with unspecified diabetic retinopathy without macular edema
E13.32 Other specified diabetes mellitus with mild nonproliferative diabetic retinopathy
Other specified diabetes mellitus with nonproliferative diabetic retinopathy NOS
E13.321 Other specified diabetes mellitus with mild nonproliferative diabetic retinopathy with macular edema
E13.329 Other specified diabetes mellitus with mild nonproliferative diabetic retinopathy without macular edema
E13.33 Other specified diabetes mellitus with moderate nonproliferative diabetic retinopathy
E13.331 Other specified diabetes mellitus with moderate nonproliferative diabetic retinopathy with macular edema
E13.339 Other specified diabetes mellitus with moderate nonproliferative diabetic retinopathy without macular edema
E13.34 Other specified diabetes mellitus with severe nonproliferative diabetic retinopathy
E13.341 Other specified diabetes mellitus with severe nonproliferative diabetic retinopathy with macular edema
E13.349 Other specified diabetes mellitus with severe nonproliferative diabetic retinopathy without macular edema
E13.35 Other specified diabetes mellitus with proliferative diabetic retinopathy
E13.351 Other specified diabetes mellitus with proliferative diabetic retinopathy with macular edema
E13.359 Other specified diabetes mellitus with proliferative diabetic retinopathy without macular edema
E13.36 Other specified diabetes mellitus with diabetic cataract
E13.39 Other specified diabetes mellitus with other diabetic ophthalmic complication
E13.4 Other specified diabetes mellitus with neurological complications
E13.40 Other specified diabetes mellitus with diabetic neuropathy, unspecified
E13.41 Other specified diabetes mellitus with diabetic mononeuropathy
E13.42 Other specified diabetes mellitus with diabetic polyneuropathy
Other specified diabetes mellitus with diabetic neuralgia
E13.43 Other specified diabetes mellitus with diabetic autonomic (poly)neuropathy
Other specified diabetes mellitus with diabetic gastroparesis
E13.44 Other specified diabetes mellitus with diabetic amyotrophy
E13.49 Other specified diabetes mellitus with other diabetic neurological complication
E13.5 Other specified diabetes mellitus with circulatory complications
E13.51 Other specified diabetes mellitus with diabetic peripheral angiopathy without gangrene
E13.52 Other specified diabetes mellitus with diabetic peripheral angiopathy with gangrene
Other specified diabetes mellitus with diabetic gangrene
E13.59 Other specified diabetes mellitus with other circulatory complications
E13.6 Other specified diabetes mellitus with other specified complications
E13.61 Other specified diabetes mellitus with diabetic arthropathy
E13.610 Other specified diabetes mellitus with diabetic neuropathic arthropathy
Other specified diabetes mellitus with Charcot's joints
E13.618 Other specified diabetes mellitus with other diabetic arthropathy
E13.62 Other specified diabetes mellitus with skin complications
E13.620 Other specified diabetes mellitus with diabetic dermatitis
Other specified diabetes mellitus with diabetic necrobiosis lipoidica
E13.621 Other specified diabetes mellitus with foot ulcer
Use additional code to identify site of ulcer (L97.4-, L97.5-)
E13.622 Other specified diabetes mellitus with other skin ulcer
Use additional code to identify site of ulcer (L97.1-L97.9, L98.41-L98.49)
E13.628 Other specified diabetes mellitus with other skin complications
E13.63 Other specified diabetes mellitus with oral complications
E13.630 Other specified diabetes mellitus with periodontal disease
E13.638 Other specified diabetes mellitus with other oral complications
E13.64 Other specified diabetes mellitus with hypoglycemia
E13.641 Other specified diabetes mellitus with hypoglycemia with coma
E13.649 Other specified diabetes mellitus with hypoglycemia without coma
E13.65 Other specified diabetes mellitus with hyperglycemia
E13.69 Other specified diabetes mellitus with other specified complication
Use additional code to identify complication
E13.8 Other specified diabetes mellitus with unspecified complications
E13.9 Other specified diabetes mellitus without complications

Other disorders of glucose regulation and pancreatic internal secretion (E15-E16)[edit]

E15 Nondiabetic hypoglycemic coma[edit]

Includes: drug-induced insulin coma in nondiabetic
hyperinsulinism with hypoglycemic coma
hypoglycemic coma NOS

E16 Other disorders of pancreatic internal secretion[edit]

E16.0 Drug-induced hypoglycemia without coma
Code first (T36-T50) to identify drug
E16.1 Other hypoglycemia
Functional hyperinsulinism
Functional nonhyperinsulinemic hypoglycemia
Hyperinsulinism NOS
Hyperplasia of pancreatic islet beta cells NOS
Excludes1: hypoglycemia in infant of diabetic mother (P70.1)
neonatal hypoglycemia (P70.4)
E16.2 Hypoglycemia, unspecified
E16.3 Increased secretion of glucagon
Hyperplasia of pancreatic endocrine cells with glucagon excess
E16.4 Increased secretion of gastrin
Hypergastrinemia
Hyperplasia of pancreatic endocrine cells with gastrin excess
Zollinger-Ellison syndrome
E16.8 Other specified disorders of pancreatic internal secretion
Increased secretion from endocrine pancreas of growth hormone-releasing hormone
Increased secretion from endocrine pancreas of pancreatic polypeptide
Increased secretion from endocrine pancreas of somatostatin
Increased secretion from endocrine pancreas of vasoactive-intestinal polypeptide
E16.9 Disorder of pancreatic internal secretion, unspecified
Islet-cell hyperplasia NOS
Pancreatic endocrine cell hyperplasia NOS

Disorders of other endocrine glands (E20-E35)[edit]

Excludes1: galactorrhea (N64.3)
gynecomastia (N62)

E20 Hypoparathyroidism[edit]

Excludes1: Di George's syndrome (D82.1)
postprocedural hypoparathyroidism (E89.2)
tetany NOS (R29.0 )
transitory neonatal hypoparathyroidism (P71.4)
E20.0 Idiopathic hypoparathyroidism
E20.1 Pseudohypoparathyroidism
E20.8 Other hypoparathyroidism
E20.9 Hypoparathyroidism, unspecified
Parathyroid tetany

E21 Hyperparathyroidism and other disorders of parathyroid gland[edit]

Excludes1: adult osteomalacia (M83.-)
ectopic hyperparathyroidism (E34.2)
familial hypocalciuric hypercalcemia (E83.52)
hungry bone syndrome (E83.81)
infantile and juvenile osteomalacia (E55.0)
E21.0 Primary hyperparathyroidism
Hyperplasia of parathyroid
Osteitis fibrosa cystica generalisata [von Recklinghausen's disease of bone]
E21.1 Secondary hyperparathyroidism, not elsewhere classified
Excludes1: secondary hyperparathyroidism of renal origin (N25.81)
E21.2 Other hyperparathyroidism
Tertiary hyperparathyroidism
Excludes1: familial hypocalciuric hypercalcemia (E83.52)
E21.3 Hyperparathyroidism, unspecified
E21.4 Other specified disorders of parathyroid gland
E21.5 Disorder of parathyroid gland, unspecified

E22 Hyperfunction of pituitary gland[edit]

Excludes1: Cushing's syndrome (E24.-)
Nelson's syndrome (E24.1)
overproduction of ACTH not associated with Cushing's disease (E27.0)
overproduction of pituitary ACTH (E24.0)
overproduction of thyroid-stimulating hormone (E05.8-)
E22.0 Acromegaly and pituitary gigantism
Overproduction of growth hormone
Excludes1: constitutional gigantism (E34.4)
constitutional tall stature (E34.4)
increased secretion from endocrine pancreas of growth hormone-releasing hormone (E16.8)
E22.1 Hyperprolactinemia
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
E22.8 Other hyperfunction of pituitary gland
Central precocious puberty
E22.9 Hyperfunction of pituitary gland, unspecified

E23 Hypofunction and other disorders of the pituitary gland[edit]

Includes: the listed conditions whether the disorder is in the pituitary or the hypothalamus
Excludes1: postprocedural hypopituitarism (E89.3)
E23.0 Hypopituitarism
Fertile eunuch syndrome
Hypogonadotropic hypogonadism
Idiopathic growth hormone deficiency
Isolated deficiency of gonadotropin
Isolated deficiency of growth hormone
Isolated deficiency of pituitary hormone
Kallmann's syndrome
Lorain-Levi short stature
Necrosis of pituitary gland (postpartum)
Panhypopituitarism
Pituitary cachexia
Pituitary insufficiency NOS
Pituitary short stature
Sheehan's syndrome
Simmonds' disease
E23.1 Drug-induced hypopituitarism
Code first (T36-T50) to identify drug
E23.2 Diabetes insipidus
Excludes1: nephrogenic diabetes insipidus (N25.1)
E23.3 Hypothalamic dysfunction, not elsewhere classified
Excludes1: Prader-Willi syndrome (Q87.1)
Russell-Silver syndrome (Q87.1)
E23.6 Other disorders of pituitary gland
Abscess of pituitary
Adiposogenital dystrophy
E23.7 Disorder of pituitary gland, unspecified

E24 Cushing's syndrome[edit]

Excludes1: congenital adrenal hyperplasia (E25.0)
E24.0 Pituitary-dependent Cushing's disease
Overproduction of pituitary ACTH
Pituitary-dependent hypercorticalism
E24.1 Nelson's syndrome
E24.2 Drug-induced Cushing's syndrome
Code first (T36-T50) to identify drug
E24.3 Ectopic ACTH syndrome
E24.4 Alcohol-induced pseudo-Cushing's syndrome
E24.8 Other Cushing's syndrome
E24.9 Cushing's syndrome, unspecified

E25 Adrenogenital disorders[edit]

Includes: adrenogenital syndromes, virilizing or feminizing, whether acquired or due to adrenal hyperplasia consequent on inborn enzyme defects in hormone synthesis
female:
adrenal pseudohermaphroditism
heterosexual precocious pseudopuberty
male:
isosexual precocious pseudopuberty
macrogenitosomia praecox
sexual precocity with adrenal hyperplasia
virilization (female)
Excludes1: indeterminate sex and pseudohermaphroditism (Q56)
chromosomal abnormalities (Q90-Q99)
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
Congenital adrenal hyperplasia
21-Hydroxylase deficiency
Salt-losing congenital adrenal hyperplasia
E25.8 Other adrenogenital disorders
Idiopathic adrenogenital disorder
E25.9 Adrenogenital disorder, unspecified
Adrenogenital syndrome NOS

E26 Hyperaldosteronism[edit]

E26.0 Primary hyperaldosteronism
E26.01 Conn's syndrome
Code also adrenal adenoma (D35.0)
E26.02 Glucocorticoid-remediable aldosteronism
Familial aldosteronism type I
E26.09 Other primary hyperaldosteronism
Primary aldosteronism due to adrenal hyperplasia (bilateral)
E26.1 Secondary hyperaldosteronism
E26.8 Other hyperaldosteronism
E26.81 Bartter?s syndrome
E26.89 Other hyperaldosteronism
E26.9 Hyperaldosteronism, unspecified
Aldosteronism NOS
Hyperaldosteronism NOS

E27 Other disorders of adrenal gland[edit]

E27.0 Other adrenocortical overactivity
Overproduction of ACTH, not associated with Cushing's disease
Premature adrenarche
Excludes1: Cushing's syndrome (E24.-)
E27.1 Primary adrenocortical insufficiency
Addison's disease
Autoimmune adrenalitis
Excludes1: Addison only phenotype adrenoleukodystrophy (E71.428)
amyloidosis (E85.-)
tuberculous Addison's disease (A18.7)
Waterhouse-Friderichsen syndrome (A39.1)
E27.2 Addisonian crisis
Adrenal crisis
Adrenocortical crisis
E27.3 Drug-induced adrenocortical insufficiency
Code first (T36-T50) to identify drug
E27.4 Other and unspecified adrenocortical insufficiency
Excludes1: adrenoleukodystrophy [Addison-Schilder] (E71.3-)
Waterhouse-Friderichsen syndrome (A39.1)
E27.40 Unspecified adrenocortical insufficiency
Adrenocortical insufficiency NOS
Hypoaldosteronism
E27.49 Other adrenocortical insufficiency
Adrenal hemorrhage
Adrenal infarction
E27.5 Adrenomedullary hyperfunction
Adrenomedullary hyperplasia
Catecholamine hypersecretion
E27.8 Other specified disorders of adrenal gland
Abnormality of cortisol-binding globulin
E27.9 Disorder of adrenal gland, unspecified

E28 Ovarian dysfunction[edit]

Excludes1: isolated gonadotropin deficiency (E23.0)
postprocedural ovarian failure (E89.4-)
E28.0 Estrogen excess
E28.1 Androgen excess
Hypersecretion of ovarian androgens
E28.2 Polycystic ovarian syndrome
Sclerocystic ovary syndrome
Stein-Leventhal syndrome
E28.3 Primary ovarian failure
Excludes1: pure gonadal dysgenesis (Q99.1)
Turner's syndrome (Q96.-)
E28.31 Premature menopause
E28.310 Symptomatic premature menopause
Symptoms such as flushing, sleeplessness, headache, lack of concentration, associated with premature menopause
E28.319 Asymptomatic premature menopause
Premature menopause NOS
E28.39 Other primary ovarian failure
Decreased estrogen
Resistant ovary syndrome
E28.8 Other ovarian dysfunction
Ovarian hyperfunction NOS
Excludes1: postprocedural ovarian failure (E89.4-)
E28.9 Ovarian dysfunction, unspecified

E29 Testicular dysfunction[edit]

Excludes1: androgen insensitivity syndrome (E34.5-)
azoospermia or oligospermia NOS (N46.0-N46.1)
isolated gonadotropin deficiency (E23.0)
Klinefelter's syndrome (Q98.0-Q98.2, Q98.4)
E29.0 Testicular hyperfunction
Hypersecretion of testicular hormones
E29.1 Testicular hypofunction
Defective biosynthesis of testicular androgen NOS
5-delta-Reductase deficiency (with male pseudohermaphroditism)
Testicular hypogonadism NOS
Excludes1: postprocedural testicular hypofunction (E89.5)
E29.8 Other testicular dysfunction
E29.9 Testicular dysfunction, unspecified

E30 Disorders of puberty, not elsewhere classified[edit]

E30.0 Delayed puberty
Constitutional delay of puberty
Delayed sexual development
E30.1 Precocious puberty
Precocious menstruation
Excludes1: Albright (-McCune) (-Sternberg) syndrome (Q78.1)
central precocious puberty (E22.8)
congenital adrenal hyperplasia (E25.0)
female heterosexual precocious pseudopuberty (E25.-)
male isosexual precocious pseudopuberty (E25.-)
E30.8 Other disorders of puberty
Premature thelarche
E30.9 Disorder of puberty, unspecified

E31 Polyglandular dysfunction[edit]

Excludes1: ataxia telangiectasia [Louis-Bar] (G11.3)
dystrophia myotonica [Steinert] (G71.11)
pseudohypoparathyroidism (E20.1)
E31.0 Autoimmune polyglandular failure
Schmidt's syndrome
E31.1 Polyglandular hyperfunction
Excludes1: multiple endocrine adenomatosis (E31.2-)
multiple endocrine neoplasia (E31.2-)
E31.2 Multiple endocrine neoplasia [MEN] syndromes
Multiple endocrine adenomatosis
Code also any associated malignancies and other conditions associated with the syndromes
E31.20 Multiple endocrine neoplasia [MEN] syndrome, unspecified
Multiple endocrine adenomatosis NOS
Multiple endocrine neoplasia [MEN] syndrome NOS
E31.21 Multiple endocrine neoplasia [MEN] type I
Wermer's syndrome
E31.22 Multiple endocrine neoplasia [MEN] type IIA
Sipple's syndrome
E31.23 Multiple endocrine neoplasia [MEN] type IIB
E31.8 Other polyglandular dysfunction
E31.9 Polyglandular dysfunction, unspecified

E32 Diseases of thymus[edit]

Excludes1: aplasia or hypoplasia of thymus with immunodeficiency (D82.1)
myasthenia gravis (G70.0)
E32.0 Persistent hyperplasia of thymus
Hypertrophy of thymus
E32.1 Abscess of thymus
E32.8 Other diseases of thymus
Excludes1: aplasia or hypoplasia with immunodeficiency (D82.1)
thymoma (D15.0)
E32.9 Disease of thymus, unspecified

E34 Other endocrine disorders[edit]

Excludes1: pseudohypoparathyroidism (E20.1)
E34.0 Carcinoid syndrome
Note: May be used as an additional code to identify functional activity associated with a carcinoid tumor.
E34.1 Other hypersecretion of intestinal hormones
E34.2 Ectopic hormone secretion, not elsewhere classified
Excludes1: ectopic ACTH syndrome (E24.3)
E34.3 Short stature due to endocrine disorder
Constitutional short stature
Laron-type short stature
Excludes1: achondroplastic short stature (Q77.4)
hypochondroplastic short stature (Q77.4)
nutritional short stature (E45)
pituitary short stature (E23.0)
progeria (E34.8)
renal short stature (N25.0)
Russell-Silver syndrome (Q87.1)
short-limbed stature with immunodeficiency (D82.2)
short stature in specific dysmorphic syndromes - code to syndrome - see Alphabetical Index
short stature NOS (R62.52)
E34.4 Constitutional tall stature
Constitutional gigantism
E34.5 Androgen insensitivity syndrome
E34.50 Androgen insensitivity syndrome, unspecified
Androgen insensitivity NOS
E34.51 Complete androgen insensitivity syndrome
Complete androgen insensitivity
de Quervain syndrome
Goldberg-Maxwell syndrome
E34.52 Partial androgen insensitivity syndrome
Partial androgen insensitivity
Reifenstein syndrome
E34.8 Other specified endocrine disorders
Pineal gland dysfunction
Progeria
Excludes2: pseudohypoparathyroidism (E20.1)
E34.9 Endocrine disorder, unspecified
Endocrine disturbance NOS
Hormone disturbance NOS

E35 Disorders of endocrine glands in diseases classified elsewhere[edit]

Code first underlying disease, such as:
late congenital syphilis of thymus gland [Dubois disease] (A50.5)
tuberculous calcification of adrenal gland (B90.8)
Excludes1: Echinococcus granulosus infection of thyroid gland (B67.3)
meningococcal hemorrhagic adrenalitis (A39.1)
syphilis of endocrine gland (A52.79)
tuberculosis of:
adrenal gland, except calcification (A18.7)
endocrine gland NEC (A18.82)
thyroid gland (A18.81)
Waterhouse-Friderichsen syndrome (A39.1)

E36 Intraoperative complications of endocrine system[edit]

Excludes2: postprocedural endocrine and metabolic complications and disorders, not elsewhere classified (E89.-)
E36.0 Intraoperative hemorrhage and hematoma of an endocrine system organ or structure complicating a procedure
Excludes1: intraoperative hemorrhage and hematoma of an endocrine system organ or structure due to accidental puncture or laceration during a procedure (E36.1-)
E36.01 Intraoperative hemorrhage and hematoma of an endocrine system organ or structure complicating an endocrine system procedure
E36.02 Intraoperative hemorrhage and hematoma of an endocrine system organ or structure complicating other procedure
E36.1 Accidental puncture and laceration of an endocrine system organ or structure during a procedure
E36.11 Accidental puncture and laceration of an endocrine system organ or structure during an endocrine system procedure
E36.12 Accidental puncture and laceration of an endocrine system organ or structure during other procedure
E36.8 Other intraoperative complications of endocrine system
Use additional code, if applicable, to further specify disorder

Malnutrition (E40-E46)[edit]

Excludes1: intestinal malabsorption (K90.-)
sequelae of protein-calorie malnutrition (E64.0)
Excludes2: nutritional anemias (D50-D53)
starvation (T73.0)

E40 Kwashiorkor[edit]

Includes: severe malnutrition with nutritional edema with dyspigmentation of skin and hair
Excludes1: marasmic kwashiorkor (E42)

E41 Nutritional marasmus[edit]

Includes: severe malnutrition with marasmus
Excludes1: marasmic kwashiorkor (E42)

E42 Marasmic kwashiorkor[edit]

Includes: severe protein-calorie malnutrition with signs of both kwashiorkor and marasmus
intermediate form severe protein-calorie malnutrition

E43 Unspecified severe protein-calorie malnutrition[edit]

Includes: starvation edema

E44 Protein-calorie malnutrition of moderate and mild degree[edit]

E44.0 Moderate protein-calorie malnutrition
E44.1 Mild protein-calorie malnutrition

E45 Retarded development following protein-calorie malnutrition[edit]

Includes: nutritional short stature
nutritional stunting
physical retardation due to malnutrition

E46 Unspecified protein-calorie malnutrition[edit]

Includes: malnutrition NOS
protein-calorie imbalance NOS
Excludes1: nutritional deficiency NOS (E63.9)

Other nutritional deficiencies (E50-E64)[edit]

Excludes2: nutritional anemias (D50-D53)

E50 Vitamin A deficiency[edit]

Excludes1: sequelae of vitamin A deficiency (E64.1)
E50.0 Vitamin A deficiency with conjunctival xerosis
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
Bitot's spot in the young child
E50.2 Vitamin A deficiency with corneal xerosis
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
E50.4 Vitamin A deficiency with keratomalacia
E50.5 Vitamin A deficiency with night blindness
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
E50.7 Other ocular manifestations of vitamin A deficiency
Xerophthalmia NOS
E50.8 Other manifestations of vitamin A deficiency
Follicular keratosis
Xeroderma
E50.9 Vitamin A deficiency, unspecified
Hypovitaminosis A NOS

E51 Thiamine deficiency[edit]

Excludes1: sequelae of thiamine deficiency (E64.8)
E51.1 Beriberi
E51.11 Dry beriberi
Beriberi NOS
Beriberi with polyneuropathy
E51.12 Wet beriberi
Beriberi with cardiovascular manifestations
Cardiovascular beriberi
Shoshin disease
E51.2 Wernicke's encephalopathy
E51.8 Other manifestations of thiamine deficiency
E51.9 Thiamine deficiency, unspecified

E52 Niacin deficiency [pellagra][edit]

Includes: niacin (-tryptophan) deficiency
nicotinamide deficiency
pellagra (alcoholic)
Excludes1: sequelae of niacin deficiency (E64.8)

E53 Deficiency of other B group vitamins[edit]

Excludes1: sequelae of vitamin B deficiency (E64.8)
E53.0 Riboflavin deficiency
Ariboflavinosis
Vitamin B2 deficiency
E53.1 Pyridoxine deficiency
Vitamin B6 deficiency
Excludes1: pyridoxine-responsive sideroblastic anemia (D64.3)
E53.8 Deficiency of other specified B group vitamins
Biotin deficiency
Cyanocobalamin deficiency
Folate deficiency
Folic acid deficiency
Pantothenic acid deficiency
Vitamin B12 deficiency
Excludes1: folate deficiency anemia (D52.-)
vitamin B12 deficiency anemia (D51.-)
E53.9 Vitamin B deficiency, unspecified

E54 Ascorbic acid deficiency[edit]

Includes: deficiency of vitamin C
scurvy
Excludes1: scorbutic anemia (D53.2)
sequelae of vitamin C deficiency (E64.2)

E55 Vitamin D deficiency[edit]

Excludes1: adult osteomalacia (M83.-)
osteoporosis (M80-)
sequelae of rickets (E64.3)
E55.0 Rickets, active
Infantile Osteomalacia
Juvenile Osteomalacia
Excludes1: celiac rickets (K90.0)
Crohn's rickets (K50.-)
hereditary vitamin D-dependent rickets (E83.32)
inactive rickets (E64.3)
renal rickets (N25.0)
sequelae of rickets (E64.3)
vitamin D-resistant rickets (E83.31)
E55.9 Vitamin D deficiency, unspecified
Avitaminosis D

E56 Other vitamin deficiencies[edit]

Excludes1: sequelae of other vitamin deficiencies (E64.8)
E56.0 Deficiency of vitamin E
E56.1 Deficiency of vitamin K
Excludes1: deficiency of coagulation factor due to vitamin K deficiency (D68.4)
vitamin K deficiency of newborn (P53)
E56.8 Deficiency of other vitamins
E56.9 Vitamin deficiency, unspecified

E58 Dietary calcium deficiency[edit]

Excludes1: disorders of calcium metabolism (E83.5)
sequelae of calcium deficiency (E64.8)

E59 Dietary selenium deficiency[edit]

Includes: Keshan disease
Excludes1: sequelae of selenium deficiency (E64.8)

E60 Dietary zinc deficiency[edit]

E61 Deficiency of other nutrient elements[edit]

Excludes1: disorders of mineral metabolism (E83.-)
iodine deficiency related thyroid disorders (E00-E02)
sequelae of malnutrition and other nutritional deficiencies (E64.-)
E61.0 Copper deficiency
E61.1 Iron deficiency
Excludes1: iron deficiency anemia (D50.-)
E61.2 Magnesium deficiency
E61.3 Manganese deficiency
E61.4 Chromium deficiency
E61.5 Molybdenum deficiency
E61.6 Vanadium deficiency
E61.7 Deficiency of multiple nutrient elements
E61.8 Deficiency of other specified nutrient elements
E61.9 Deficiency of nutrient element, unspecified

E63 Other nutritional deficiencies[edit]

Excludes1: dehydration (E86.0)
failure to thrive, adult (R62.7)
failure to thrive, child (R62.51)
feeding problems in newborn (P92.-)
sequelae of malnutrition and other nutritional deficiencies (E64.-)
E63.0 Essential fatty acid [EFA] deficiency
E63.1 Imbalance of constituents of food intake
E63.8 Other specified nutritional deficiencies
E63.9 Nutritional deficiency, unspecified

E64 Sequelae of malnutrition and other nutritional deficiencies[edit]

This category is to be used to indicate conditions in categories E43, E44, E46, E50-E63 as the cause of sequelae, which are themselves classified elsewhere. The "sequelae" include conditions specified as such; they also include the late effects of diseases classifiable to the above categories if the disease itself is no longer present


Code first condition resulting from (sequela) of malnutrition and other nutritional deficiencies
E64.0 Sequelae of protein-calorie malnutrition
Excludes2: retarded development following protein-calorie malnutrition (E45)
E64.1 Sequelae of vitamin A deficiency
E64.2 Sequelae of vitamin C deficiency
E64.3 Sequelae of rickets
E64.8 Sequelae of other nutritional deficiencies
E64.9 Sequelae of unspecified nutritional deficiency

Overweight, obesity and other hyperalimentation (E65-E68)[edit]

E65 Localized adiposity[edit]

Fat pad

E66 Overweight and obesity[edit]

Code first: obesity complicating pregnancy, childbirth and the puerperium, if applicable (O99.21-)
Use additional code to identify body mass index (BMI), if known (Z68.-)
Excludes1: adiposogenital dystrophy (E23.6)
lipomatosis NOS (E88.2)
lipomatosis dolorosa [Dercum] (E88.2)
Prader-Willi syndrome (Q87.1)
E66.0 Obesity due to excess calories
E66.01 Morbid (severe) obesity due to excess calories
Excludes1: morbid (severe) obesity with alveolar hypoventilation (E66.2)
E66.09 Other obesity due to excess calories
E66.1 Drug-induced obesity
Code first (T36-T50) to identify drug
E66.2 Morbid (severe) obesity with alveolar hypoventilation
Pickwickian syndrome
E66.3 Overweight
E66.8 Other obesity
E66.9 Obesity, unspecified
Obesity NOS

E67 Other hyperalimentation[edit]

Excludes1: hyperalimentation NOS (R63.2)
sequelae of hyperalimentation (E68)
E67.0 Hypervitaminosis A
E67.1 Hypercarotinemia
E67.2 Megavitamin-B6 syndrome
E67.3 Hypervitaminosis D
E67.8 Other specified hyperalimentation

E68 Sequelae of hyperalimentation[edit]

Code first condition resulting from (sequela) of hyperalimentation

Metabolic disorders (E70-E90)[edit]

Excludes1: androgen insensitivity syndrome (E34.5-)
congenital adrenal hyperplasia (E25.0)
Ehlers-Danlos syndrome (Q79.6)
hemolytic anemias attributable to enzyme disorders (D55.-)
Marfan's syndrome (Q87.4)
5-alpha-reductase deficiency (E29.1)

E70 Disorders of aromatic amino-acid metabolism[edit]

E70.0 Classical phenylketonuria
E70.1 Other hyperphenylalaninemias
E70.2 Disorders of tyrosine metabolism
Excludes1: transitory tyrosinemia of newborn (P74.5)
E70.20 Disorder of tyrosine metabolism, unspecified
E70.21 Tyrosinemia
Hypertyrosinemia
E70.29 Other disorders of tyrosine metabolism
Alkaptonuria
Ochronosis
E70.3 Albinism
E70.30 Albinism, unspecified
E70.31 Ocular albinism
E70.310 X-linked ocular albinism
E70.311 Autosomal recessive ocular albinism
E70.318 Other ocular albinism
E70.319 Ocular albinism, unspecified
E70.32 Oculocutaneous albinism
Excludes1: Chediak-Higashi syndrome (E70.330)
Hermansky-Pudlak syndrome (E70.331)
E70.320 Tyrosinase negative oculocutaneous albinism
Albinism I
Oculocutaneous albinism ty-neg
E70.321 Tyrosinase positive oculocutaneous albinism
Albinism II
Oculocutaneous albinism ty-pos
E70.328 Other oculocutaneous albinism
Cross syndrome
E70.329 Oculocutaneous albinism, unspecified
E70.33 Albinism with hematologic abnormality
E70.330 Chediak-Higashi syndrome
E70.331 Hermansky-Pudlak syndrome
E70.338 Other albinism with hematologic abnormality
E70.339 Albinism with hematologic abnormality, unspecified
E70.39 Other specified albinism
Piebaldism
E70.4 Disorders of histidine metabolism
E70.40 Disorders of histidine metabolism, unspecified
E70.41 Histidinemia
E70.49 Other disorders of histidine metabolism
E70.5 Disorders of tryptophan metabolism
E70.8 Other disorders of aromatic amino-acid metabolism
E70.9 Disorder of aromatic amino-acid metabolism, unspecified

E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism[edit]

E71.0 Maple-syrup-urine disease
E71.1 Other disorders of branched-chain amino-acid metabolism
E71.11 Branched-chain organic acidurias
E71.110 Isovaleric acidemia
E71.111 3-methylglutaconic aciduria
E71.118 Other branched-chain organic acidurias
E71.12 Disorders of propionate metabolism
E71.120 Methylmalonic acidemia
E71.121 Propionic acidemia
E71.128 Other disorders of propionate metabolism
E71.19 Other disorders of branched-chain amino-acid metabolism
Hyperleucine-isoleucinemia
Hypervalinemia
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
E71.3 Disorders of fatty-acid metabolism
Excludes1: peroxisomal disorders (E71.5)
Refsum's disease (G60.1)
Schilder's disease (G37.0)
Excludes2: carnitine deficiency due to inborn error of metabolism (E71.42)
E71.30 Disorder of fatty-acid metabolism, unspecified
E71.31 Disorders of fatty-acid oxidation
E71.310 Long chain/very long chain acyl CoA dehydrogenase deficiency
LCAD
VLCAD
E71.311 Medium chain acyl CoA dehydrogenase deficiency
MCAD
E71.312 Short chain acyl CoA dehydrogenase deficiency
SCAD
E71.313 Glutaric aciduria type II
Glutaric aciduria type II A
Glutaric aciduria type II B
Glutaric aciduria type II C
Excludes1: glutaric aciduria (type 1) NOS (E72.3)
E71.314 Muscle carnitine palmitoyltransferase deficiency
E71.318 Other disorders of fatty-acid oxidation
E71.32 Disorders of ketone metabolism
E71.39 Other disorders of fatty-acid metabolism
E71.4 Disorders of carnitine metabolism
Excludes1: Muscle carnitine palmitoyltransferase deficiency (E71.314)
E71.40 Disorder of carnitine metabolism, unspecified
E71.41 Primary carnitine deficiency
E71.42 Carnitine deficiency due to inborn errors of metabolism
Code also associated inborn error or metabolism
E71.43 Iatrogenic carnitine deficiency
Carnitine deficiency due to:
hemodialysis
Valproic acid therapy
E71.44 Other secondary carnitine deficiency
E71.440 Ruvalcaba-Myhre-Smith syndrome
E71.448 Other secondary carnitine deficiency
E71.5 Peroxisomal disorders
Excludes1: Schilder?s disease (G37.0)
E71.50 Peroxisomal disorder, unspecified
E71.51 Disorders of peroxisome biogenesis
Group 1 peroxisomal disorders
Excludes1: Refsum's disease (G60.1)
E71.510 Zellweger syndrome
E71.511 Neonatal adrenoleukodystrophy
Excludes1: X-linked adrenoleukodystrophy (E71.42-)
E71.518 Other disorders of peroxisome biogenesis
E71.52 X-linked adrenoleukodystrophy
E71.520 Childhood cerebral X-linked adrenoleukodystrophy
E71.521 Adolescent X-linked adrenoleukodystrophy
E71.522 Adrenomyeloneuropathy
E71.528 Other X-linked adrenoleukodystrophy
Addison only phenotype adrenoleukodystrophy
Addison-Schilder adrenoleukodystrophy
E71.529 X-linked adrenoleukodystrophy, unspecified
E71.53 Other group 2 peroxisomal disorders
E71.54 Other peroxisomal disorders
E71.540 Rhizomelic chondrodysplasia punctata
Excludes1: chondrodysplasia punctata NOS (Q77.3)
E71.541 Zellweger-like syndrome
E71.542 Other group 3 peroxisomal disorders
E71.548 Other peroxisomal disorders

E72 Other disorders of amino-acid metabolism[edit]

Excludes1: disorders of:
aromatic amino-acid metabolism (E70.-)
branched-chain amino-acid metabolism (E71.0-E71.2)
fatty-acid metabolism (E71.3)
purine and pyrimidine metabolism (E79.-)
gout ( M1a-, M10.-)
E72.0 Disorders of amino-acid transport
Excludes1: disorders of tryptophan metabolism (E70.5)
E72.00 Disorders of amino-acid transport, unspecified
E72.01 Cystinuria
E72.02 Hartnup's disease
E72.03 Lowe's syndrome
Use additional code for associated glaucoma (H42)
E72.04 Cystinosis
Fanconi (-de Toni) (-Debr?) syndrome with cystinosis
Excludes1: Fanconi (-de Toni) (-Debr?) syndrome without cystinosis (E72.09)
E72.09 Other disorders of amino-acid transport
Fanconi (-de Toni) (-Debr?) syndrome, unspecified
E72.1 Disorders of sulfur-bearing amino-acid metabolism
Excludes1: cystinosis (E72.04)
cystinuria (E72.01)
transcobalamin II deficiency (D51.2)
E72.10 Disorders of sulfur-bearing amino-acid metabolism, unspecified
E72.11 Homocystinuria
Cystathionine synthase deficiency
E72.12 Methylenetetrahydrofolate reductase deficiency
E72.19 Other disorders of sulfur-bearing amino-acid metabolism
Cystathioninuria
Methioninemia
Sulfite oxidase deficiency
E72.2 Disorders of urea cycle metabolism
Excludes1: disorders of ornithine metabolism (E72.4)
E72.20 Disorder of urea cycle metabolism, unspecified
Hyperammonemia
Excludes1: hyperammonemia-hyperornithinemia-homocitrullinemia syndrome E72.4
transient hyperammonemia of newborn (P74.6)
E72.21 Argininemia
E72.22 Arginosuccinic aciduria
E72.23 Citrullinemia
E72.29 Other disorders of urea cycle metabolism
E72.3 Disorders of lysine and hydroxylysine metabolism
Glutaric aciduria NOS
Glutaric aciduria (type I)
Hydroxylysinemia
Hyperlysinemia
Excludes1: glutaric aciduria type II (E71.313)
Refsum's disease (G60.1)
Zellweger syndrome (E71.510)
E72.4 Disorders of ornithine metabolism
Hyperammonemia-Hyperornithinemia-Homocitrullinemia syndrome
Ornithinemia (types I, II)
Ornithine transcarbamylase deficiency
Excludes1: hereditary choroidal dystrophy (H31.2-)
E72.5 Disorders of glycine metabolism
E72.50 Disorder of glycine metabolism, unspecified
E72.51 Non-ketotic hyperglycinemia
E72.52 Trimethylaminuria
E72.53 Hyperoxaluria
Oxalosis
Oxaluria
E72.59 Other disorders of glycine metabolism
D-glycericacidemia
Hyperhydroxyprolinemia
Hyperprolinemia (types I, II)
Sarcosinemia
E72.8 Other specified disorders of amino-acid metabolism
Disorders of beta-amino-acid metabolism
Disorders of gamma-glutamyl cycle
E72.9 Disorder of amino-acid metabolism, unspecified

E73 Lactose intolerance[edit]

E73.0 Congenital lactase deficiency
E73.1 Secondary lactase deficiency
E73.8 Other lactose intolerance
E73.9 Lactose intolerance, unspecified

E74 Other disorders of carbohydrate metabolism[edit]

Excludes1: diabetes mellitus (E09-E13)
hypoglycemia NOS (E16.2)
increased secretion of glucagon (E16.3)
mucopolysaccharidosis (E76.0--E76.3)
E74.0 Glycogen storage disease
E74.00 Glycogen storage disease, unspecified
E74.01 von Gierke disease
Type I glycogen storage disease
E74.02 Pompe disease
Cardiac glycogenosis
Type II glycogen storage disease
E74.03 Cori disease
Forbes disease
Type III glycogen storage disease
E74.04 McArdle disease
Type V glycogen storage disease
E74.09 Other glycogen storage disease
Andersen disease
Hers disease
Tauri disease
Glycogen storage disease, types 0, IV, VI-XI
Liver phosphorylase deficiency
Muscle phosphofructokinase deficiency
E74.1 Disorders of fructose metabolism
Excludes1: muscle phosphofructokinase deficiency (E74.09)
E74.10 Disorder of fructose metabolism, unspecified
E74.11 Essential fructosuria
Fructokinase deficiency
E74.12 Hereditary fructose intolerance
Fructosemia
E74.19 Other disorders of fructose metabolism
Fructose-1, 6-diphosphatase deficiency
E74.2 Disorders of galactose metabolism
E74.20 Disorders of galactose metabolism, unspecified
E74.21 Galactosemia
E74.29 Other disorders of galactose metabolism
Galactokinase deficiency
E74.3 Other disorders of intestinal carbohydrate absorption
Excludes2: lactose intolerance (E73.-)
E74.31 Sucrase-isomaltase deficiency
E74.39 Other disorders of intestinal carbohydrate absorption
Disorder of intestinal carbohydrate absorption NOS
Glucose-galactose malabsorption
Sucrase deficiency
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
Deficiency of phosphoenolpyruvate carboxykinase
Deficiency of pyruvate carboxylase
Deficiency of pyruvate dehydrogenase
Excludes1: disorders of pyruvate metabolism and gluconeogenesis with anemia (D55.-)
Leigh?s syndrome (G31.82)
E74.8 Other specified disorders of carbohydrate metabolism
Essential pentosuria
Renal glycosuria
E74.9 Disorder of carbohydrate metabolism, unspecified

E75 Disorders of sphingolipid metabolism and other lipid storage disorders[edit]

Excludes1: mucolipidosis, types I-III (E77.0-E77.1)
Refsum's disease (G60.1)
E75.0 GM2 gangliosidosis
E75.00 GM2 gangliosidosis, unspecified
E75.01 Sandhoff disease
E75.02 Tay-Sachs disease
E75.09 Other GM2 gangliosidosis
Adult GM2 gangliosidosis
Juvenile GM2 gangliosidosis
E75.1 Other and unspecified gangliosidosis
E75.10 Unspecified gangliosidosis
Gangliosidosis NOS
E75.11 Mucolipidosis IV
E75.19 Other gangliosidosis
GM1 gangliosidosis
GM3 gangliosidosis
E75.2 Other sphingolipidosis
Excludes1: adrenoleukodystrophy [Addison-Schilder] (E71.30)
E75.21 Fabry (-Anderson) disease
E75.22 Gaucher disease
E75.23 Krabbe disease
E75.24 Niemann-Pick disease
E75.240 Niemann-Pick disease type A
E75.241 Niemann-Pick disease type B
E75.242 Niemann-Pick disease type C
E75.243 Niemann-Pick disease type D
E75.248 Other Niemann-Pick disease
E75.249 Niemann-Pick disease, unspecified
E75.25 Metachromatic leukodystrophy
E75.29 Other sphingolipidosis
Farber's syndrome
Sulfatase deficiency
Sulfatide lipidosis
E75.3 Sphingolipidosis, unspecified
E75.4 Neuronal ceroid lipofuscinosis
Batten disease
Bielschowsky-Jansky disease
Kufs disease
Spielmeyer-Vogt disease
E75.5 Other lipid storage disorders
Cerebrotendinous cholesterosis [van Bogaert-Scherer-Epstein]
Wolman's disease
E75.6 Lipid storage disorder, unspecified

E76 Disorders of glycosaminoglycan metabolism[edit]

E76.0 Mucopolysaccharidosis, type I
E76.01 Hurler?s syndrome
E76.02 Hurler-Scheie syndrome
E76.03 Scheie?s syndrome
E76.1 Mucopolysaccharidosis, type II
Hunter's syndrome
E76.2 Other mucopolysaccharidoses
E76.21 Morquio mucopolysaccharidoses
E76.210 Morquio A mucopolysaccharidoses
Classic Morquio syndrome
Morquio syndrome A
Mucopolysaccharidosis, type IVA
E76.211 Morquio B mucopolysaccharidoses
Morquio-like mucopolysaccharidoses
Morquio-like syndrome
Morquio syndrome B
Mucopolysaccharidosis, type IVB
E76.219 Morquio mucopolysaccharidoses, unspecified
Morquio syndrome
Mucopolysaccharidosis, type IV
E76.22 Sanfilippo mucopolysaccharidoses
Mucopolysaccharidosis, type III (A) (B) (C) (D)
Sanfilippo A syndrome
Sanfilippo B syndrome
Sanfilippo C syndrome
Sanfilippo D syndrome
E76.29 Other mucopolysaccharidoses
beta-Glucuronidase deficiency
Maroteaux-Lamy (mild) (severe) syndrome
Mucopolysaccharidosis, types VI, VII
E76.3 Mucopolysaccharidosis, unspecified
E76.8 Other disorders of glucosaminoglycan metabolism
E76.9 Glucosaminoglycan metabolism disorder, unspecified

E77 Disorders of glycoprotein metabolism[edit]

E77.0 Defects in post-translational modification of lysosomal enzymes
Mucolipidosis II [I-cell disease]
Mucolipidosis III [pseudo-Hurler polydystrophy]
E77.1 Defects in glycoprotein degradation
Aspartylglucosaminuria
Fucosidosis
Mannosidosis
Sialidosis [mucolipidosis I]
E77.8 Other disorders of glycoprotein metabolism
E77.9 Disorder of glycoprotein metabolism, unspecified
E78 Disorders of lipoprotein metabolism and other lipidemias
Excludes1: sphingolipidosis (E75.0-E75.3)

E78.0 Pure hypercholesterolemia[edit]

Familial hypercholesterolemia
Fredrickson's hyperlipoproteinemia, type IIa
Hyperbetalipoproteinemia
Hyperlipidemia, Group A
Low-density-lipoprotein-type [LDL] hyperlipoproteinemia
E78.1 Pure hyperglyceridemia
Elevated fasting triglycerides
Endogenous hyperglyceridemia
Fredrickson's hyperlipoproteinemia, type IV
Hyperlipidemia, group B
Hyperprebetalipoproteinemia
Very-low-density-lipoprotein-type [VLDL] hyperlipoproteinemia
E78.2 Mixed hyperlipidemia
Broad- or floating-betalipoproteinemia
Combined hyperlipidemia NOS
Elevated cholesterol with elevated triglycerides NEC
Fredrickson's hyperlipoproteinemia, type IIb or III
Hyperbetalipoproteinemia with prebetalipoproteinemia
Hypercholesteremia with endogenous hyperglyceridemia
Hyperlipidemia, group C
Tubo-eruptive xanthoma
Xanthoma tuberosum
Excludes1: cerebrotendinous cholesterosis [van Bogaert-Scherer- Epstein] (E75.5)
familial combined hyperlipidemia (E78.4)
E78.3 Hyperchylomicronemia
Chylomicron retention disease
Fredrickson's hyperlipoproteinemia, type I or V
Hyperlipidemia, group D
Mixed hyperglyceridemia
E78.4 Other hyperlipidemia
Familial combined hyperlipidemia
E78.5 Hyperlipidemia, unspecified
E78.6 Lipoprotein deficiency
Abetalipoproteinemia
Depressed HDL cholesterol
High-density lipoprotein deficiency
Hypoalphalipoproteinemia
Hypobetalipoproteinemia (familial)
Lecithin cholesterol acyltransferase deficiency
Tangier disease
E78.7 Disorders of bile acid and cholesterol metabolism
Excludes1: Niemann-Pick disease type C (E75.242)
E78.70 Disorder of bile acid and cholesterol metabolism, unspecified
E78.71 Barth syndrome
E78.72 Smith-Lemli-Opitz syndrome
E78.79 Other disorders of bile acid and cholesterol metabolism
E78.8 Other disorders of lipoprotein metabolism
E78.81 Lipoid dermatoarthritis
E78.89 Other lipoprotein metabolism disorders
E78.9 Disorder of lipoprotein metabolism, unspecified

E79 Disorders of purine and pyrimidine metabolism[edit]

Excludes1: Ataxia-telangiectasia (Q87.1)
Bloom's syndrome (Q82.8)
Cockayne's syndrome (Q87.1)
calculus of kidney (N20.0)
combined immunodeficiency disorders (D81.-)
Fanconi's anemia (D61.09)
gout ( M1a-, M10.-)
orotaciduric anemia (D53.0)
progeria (E34.8)
Werner's syndrome (E34.8)
xeroderma pigmentosum (Q82.1)
E79.0 Hyperuricemia without signs of inflammatory arthritis and tophaceous disease
Asymptomatic hyperuricemia
E79.1 Lesch-Nyhan syndrome
HGPRT deficiency
E79.2 Myoadenylate deaminase deficiency
E79.8 Other disorders of purine and pyrimidine metabolism
Hereditary xanthinuria
E79.9 Disorder of purine and pyrimidine metabolism, unspecified

E80 Disorders of porphyrin and bilirubin metabolism[edit]

Includes: defects of catalase and peroxidase
E80.0 Hereditary erythropoietic porphyria
Congenital erythropoietic porphyria
Erythropoietic protoporphyria
E80.1 Porphyria cutanea tarda
E80.2 Other and unspecified porphyria
E80.20 Unspecified porphyria
Porphyria NOS
E80.21 Acute intermittent (hepatic) porphyria
E80.29 Other porphyria
Hereditary coproporphyria
E80.3 Defects of catalase and peroxidase
Acatalasia [Takahara]
E80.4 Gilbert's syndrome
E80.5 Crigler-Najjar syndrome
E80.6 Other disorders of bilirubin metabolism
Dubin-Johnson syndrome
Rotor's syndrome
E80.7 Disorder of bilirubin metabolism, unspecified

E83 Disorders of mineral metabolism[edit]

Excludes1: dietary mineral deficiency (E58-E61)
parathyroid disorders (E20-E21)
vitamin D deficiency (E55.-)
E83.0 Disorders of copper metabolism
E83.00 Disorder of copper metabolism, unspecified
E83.01 Wilson's disease
Code also associated Kayser Fleischer ring (H18.04-)
E83.09 Other disorders of copper metabolism
Menkes' (kinky hair) (steely hair) disease
E83.1 Disorders of iron metabolism
Excludes1: iron deficiency anemia (D50.-)
sideroblastic anemia (D64.0-D64.3)
E83.10 Disorder of iron metabolism, unspecified
E83.11 Hemochromatosis
E83.19 Other disorders of iron metabolism
E83.2 Disorders of zinc metabolism
Acrodermatitis enteropathica
E83.3 Disorders of phosphorus metabolism and phosphatases
Excludes1: adult osteomalacia (M83.-)
osteoporosis (M80-)
E83.30 Disorder of phosphorus metabolism, unspecified
E83.31 Familial hypophosphatemia
Vitamin D-resistant osteomalacia
Vitamin D-resistant rickets
Excludes1: vitamin D-deficiency rickets (E55.0)
E83.32 Hereditary vitamin D-dependent rickets (type 1) (type 2)
25-hydroxyvitamin D 1-alpha-hydroxylase deficiency
Pseudovitamin D deficiency
Vitamin D receptor defect
E83.39 Other disorders of phosphorus metabolism
Acid phosphatase deficiency
Hypophosphatasia
E83.4 Disorders of magnesium metabolism
E83.40 Disorders of magnesium metabolism, unspecified
E83.41 Hypermagnesemia
E83.42 Hypomagnesemia
E83.49 Other disorders of magnesium metabolism
E83.5 Disorders of calcium metabolism
Excludes1: chondrocalcinosis (M11.1-M11.2)
hungry bone syndrome (E83.81)
hyperparathyroidism (E21.0-E21.3)
E83.50 Unspecified disorder of calcium metabolism
E83.51 Hypocalcemia
E83.52 Hypercalcemia
Familial hypocalciuric hypercalcemia
E83.59 Other disorders of calcium metabolism
Idiopathic hypercalciuria
E83.8 Other disorders of mineral metabolism
E83.81 Hungry bone syndrome
E83.89 Other disorders of mineral metabolism
E83.9 Disorder of mineral metabolism, unspecified

E84 Cystic fibrosis[edit]

Includes: mucoviscidosis
E84.0 Cystic fibrosis with pulmonary manifestations
Use additional code to identify any infectious organism present, such as:
Pseudomonas (B96.5)
E84.1 Cystic fibrosis with intestinal manifestations
E84.11 Meconium ileus in cystic fibrosis
Excludes1: meconium ileus not due to cystic fibrosis (P76.0)
E84.19 Cystic fibrosis with other intestinal manifestations
Distal intestinal obstruction syndrome
E84.8 Cystic fibrosis with other manifestations
E84.9 Cystic fibrosis, unspecified

E85 Amyloidosis[edit]

Excludes1: Alzheimer's disease (G30.0-)
E85.0 Non-neuropathic heredofamilial amyloidosis
Familial Mediterranean fever
Hereditary amyloid nephropathy
E85.1 Neuropathic heredofamilial amyloidosis
Amyloid polyneuropathy (Portuguese)
E85.2 Heredofamilial amyloidosis, unspecified
E85.3 Secondary systemic amyloidosis
Hemodialysis-associated amyloidosis
E85.4 Organ-limited amyloidosis
Localized amyloidosis
E85.8 Other amyloidosis
E85.9 Amyloidosis, unspecified

E86 Volume depletion[edit]

Excludes1: dehydration of newborn (P74.1)
hypovolemic shock NOS (R57.1)
postprocedural hypovolemic shock (T81.1)
traumatic hypovolemic shock (T79.4)
E86.0 Dehydration
E86.1 Hypovolemia
Depletion of volume of plasma
E86.9 Volume depletion, unspecified

E87 Other disorders of fluid, electrolyte and acid-base balance[edit]

Excludes1: diabetes insipidus (E23.2)
electrolyte imbalance associated with hyperemesis gravidarum (O21.1)
electrolyte imbalance following ectopic or molar pregnancy (O08.5)
familial periodic paralysis (G72.3)
E87.0 Hyperosmolality and hypernatremia
Sodium [Na] excess
Sodium [Na] overload
E87.1 Hypo-osmolality and hyponatremia
Sodium [Na] deficiency
Excludes1: syndrome of inappropriate secretion of antidiuretic hormone (E22.2)
E87.2 Acidosis
Acidosis NOS
Lactic acidosis
Metabolic acidosis
Respiratory acidosis
Excludes1: diabetic acidosis - see categories E10-E13 with ketoacidosis
E87.3 Alkalosis
Alkalosis NOS
Metabolic alkalosis
Respiratory alkalosis
E87.4 Mixed disorder of acid-base balance
E87.5 Hyperkalemia
Potassium [K] excess
Potassium [K] overload
E87.6 Hypokalemia
Potassium [K] deficiency
E87.7 Fluid overload
Excludes1: edema NOS (R60.-)
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
Electrolyte imbalance NOS
Hyperchloremia
Hypochloremia

E88 Other and unspecified metabolic disorders[edit]

Use additional codes for associated conditions
Excludes1: histiocytosis X (chronic) (C96.6)
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
Excludes1: disorder of lipoprotein metabolism (E78.-)
monoclonal gammopathy (of undetermined significance) (D47.2)
polyclonal hypergammaglobulinemia (D89.0)
Waldenström macroglobulinemia (C88.0)
E88.01 Alpha-1-antitrypsin deficiency
AAT deficiency
E88.09 Other disorders of plasma-protein metabolism, not elsewhere classified
Bisalbuminemia
E88.1 Lipodystrophy, not elsewhere classified
Lipodystrophy NOS
Excludes1: Whipple's disease (K90.81)
E88.2 Lipomatosis, not elsewhere classified
Lipomatosis NOS
Lipomatosis (Check) dolorosa [Dercum]
E88.3 Tumor lysis syndrome
Tumor lysis syndrome (spontaneous)
Tumor lysis syndrome following antineoplastic drug chemotherapy
Code first (T45.1-) to identify drug, if drug induced
E88.4 Mitochondrial metabolism disorders
Excludes1: disorders of pyruvate metabolism (E74.4)
Kearns-Sayre syndrome (H49.81)
Leber's disease (H47.22)
Leigh's encephalopathy (G31.82)
Mitochondrial myopathy, NEC (G71.3)
Reye's syndrome (G93.7)
E88.40 Mitochondrial metabolism disorder, unspecified
E88.41 MELAS syndrome
Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes
E88.42 MERRF syndrome
Myoclonic epilepsy associated with ragged-red fibers
Code also: myoclonic epilepsy (G40.3-)
E88.49 Other mitochondrial metabolism disorders
E88.8 Other specified metabolic disorders
E88.81 Metabolic syndrome
Dysmetabolic syndrome X
E88.89 Other specified metabolic disorders
Launois-Bensaude adenolipomatosis
E88.9 Metabolic disorder, unspecified

E89 Postprocedural endocrine and metabolic complications and disorders, not elsewhere classified[edit]

Excludes2: intraoperative complications of endocrine system organ or structure (E36.0-, E36.1-, E36.8)
E89.0 Postprocedural hypothyroidism
Postirradiation hypothyroidism
Postsurgical hypothyroidism
E89.1 Postprocedural hypoinsulinemia
Postpancreatectomy hyperglycemia
Postsurgical hypoinsulinemia
Use additional code, if applicable, to identify:
acquired absence of pancreas (Z90.89)
diabetes mellitus (E11.-)
insulin use (Z79.4)
Excludes1: transient postprocedural hyperglycemia (R73.9)
transient postprocedural hypoglycemia (E16.2)
E89.2 Postprocedural hypoparathyroidism
Parathyroprival tetany
E89.3 Postprocedural hypopituitarism
Postirradiation hypopituitarism
E89.4 Postprocedural ovarian failure
E89.40 Asymptomatic postprocedural ovarian failure
Postprocedural ovarian failure NOS
E89.41 Symptomatic postprocedural ovarian failure
Symptoms such as flushing, sleeplessness, headache, lack of concentration, associated with postprocedural menopause
E89.5 Postprocedural testicular hypofunction
E89.6 Postprocedural adrenocortical (-medullary) hypofunction
E89.8 Other postprocedural endocrine and metabolic complications and disorders
E89.81 Postprocedural hemorrhage and hematoma of an endocrine system organ or structure following a procedure
E89.810 Postprocedural hemorrhage and hematoma of an endocrine system organ or structure following an endocrine system procedure
E89.811 Postprocedural hemorrhage and hematoma of an endocrine system organ or structure following other procedure
E89.89 Other postprocedural endocrine and metabolic complications and disorders
Use additional code, if applicable, to further specify disorder