1911 Encyclopædia Britannica/Murexide

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MUREXIDE (NH4·C8H4N5O6,H2O), the ammonium salt of purpuric acid. It may be prepared by heating alloxantin in ammonia gas to 100° C., or by boiling uramil with mercuric oxide (J. v. Liebig, F. Wöhler, Ann., 1838, 26, 319), C4H5N3O3+O= NH4· C8H4N5O6+H2O. W. N. Hartley (Jour. Chem. Soc., 1905, 87, 1791) found considerable difficulty in obtaining specimens of murexide sufficiently pure to give concordant results when examined by means of their absorption spectra, and consequently devised a new method of preparation for murexide. In this process alloxantin is dissolved in a large excess of boiling absolute alcohol, and dry ammonia gas is passed into the solution for about three hours. The solution is then filtered from the precipitated murexide, which is washed with absolute alcohol and dried. The salt obtained in this way is in the anhydrous state. It may also be prepared by digesting alloxan with alcoholic ammonia at about 78° C.; the purple solid so formed is easily soluble in water, and the solution produced is indistinguishable from one of murexide,

On the constitution of murexide see also O. Piloty (Ann., 1904, 333, 30); R. Mohlau (Ber., 1904, 37, 2686); and M. Slimmer and J. Stieglitz (Amer. Chem. Jour., 1904, 31, 661).