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Mark Akenside was born on the ninth of November, 1721, at Newcastle upon Tyne. His father Mark was a butcher, of the Presbyterian sect; his mother's name was Mary Lumsden. He received the first part of his education at the grammar school of Newcastle; and was afterwards instructed by Mr. Wilson, who kept a private academy.
At the age of eighteen he was sent to Edinburgh, that he might qualify himself for the office of a dissenting minister, and received some assistance from the fund which the Dissenters employ in educating young men of scanty fortune. But a wider view of the world opened other scenes, and prompted other hopes: he determined to study physick, and repaid that contribution, which, being received for a different purpose, he justly thought it dishonourable to retain.