of his cure; but he never got beyond the idea that the cause of the complaint was a specific ferment.
The earliest really scientific contribution to the study of this disorder may be credited to Thomas Mouffet, of London, who, in a treatise published in 1634, entitled Insectorum sive Minimorum Animalium Theatrum, showed not only that the animalculæ were constantly associated with the complaint, but made it clear that they were not to be found in the vesicles, but in the tunnels connected with these. For this was the stumbling block of most of the investigators. It had been so often stated that the parasites were to be found in the vesicles, that when they were not there the theory failed. Mouffet's exposition ought to have led to a correct understanding of the cause of the complaint, but it was practically ignored.
About this time the microscope was invented, and in 1657 a German naturalist named Hauptmann published a rough drawing of the insect magnified. A better, but still imperfect, representation of it was given a few years later by Etmuller.
In 1687 a pharmacist of Leghorn, named Cestoni, induced a Dr. Bonomo of that city to join him in making a series of experiments to prove that the acarus was the cause of itch. They had both observed the women of the city extracting the insects from the hands of their children by the aid of needles, and the result of their research was a treatise in which the parasitic nature of the complaint was maintained, and the uselessness of internal remedies was insisted on. These intelligent Italians recommended sulphur or mercury ointment as the essential application.
Even with this evidence before them the doctors went on faithful to their theory of humours. Linnæus
