§ 3. The Constitution of Histones and Albumins.
Constitution of Histones.—But we are only half-way
through our task. We are acquainted in its origin
with one of the genealogical branches of the proteid,
the nucleinic branch. We must also learn something
of the other branch, the albumin or histone branch.
But on this side the problem assumes a character of
difficulty and complexity which is admirably adapted
to discourage the most untiring patience.
The analysis of albumin for a long time baulked the chemist "Here," said Danilewsky, "we come to a closed door which resists all our efforts." We know how vastly interesting what is taking place on the other side must be, but we cannot get there. We get a mere glimpse through the cracks or chinks which we have been able to make.
This analysis of albuminous matter at first requires great precautions. The chemist finds himself in the presence of architecture of a very subtle kind. The molecule of albumin is a complex edifice which has used up several thousand atoms. To perceive the plan and structure, it must be dismantled and separated into parts which are neither too large nor too small. Such careful demolition is difficult. Processes too rough or too violent will reduce the whole to the tiniest of fragments. It is a statue which may be reduced to dust, instead of being separated into recognizable fragments, easily fitted in place along their fractured faces.
Analysis of Albumin by Schützenberger.—Schützenberger, a chemist of great merit, attempted (about
