The case of the determination of nerve-branching by intra-organic relations does not by any means stand alone. The same principle undoubtedly holds for the development of the blood-vessels, which grow along paths determined by the arrangement of organs and tissues and not according to a predetermined law given in the blood-vessels themselves. Color patterns have been shown in some cases to be determined by intra-organic variable relations, as in Loeb's experiments on the determination of the color pattern of the yolk-sac of a fish, which he demonstrated to be due to the positive attraction of the circulating blood for migratory cells that bear pigment. The development of any color pattern was therefore dependent upon blood-circulation, and the form of the pattern upon the pattern of the blood-vessels. The primordia of the eye or the ear transplanted to strange locations in the embryo induce formations in surrounding tissues that are strange to them and characteristic of the normal eye and ear environment. The origin and growth of motor nerve cells has been shown in my laboratory by Miss Shorey to be dependent in the chick on normal muscle development; so that the anatomy of the central nervous system, no less than the peripheral system, is dependent to some extent on the environment. Regeneration of lost parts is dependent for its completion to some degree on innervation, and the normal development of muscle tissue beyond a certain stage is likewise so dependent. These examples might be increased by others, which, taken together, would show that an immense part of what we call inheritance is inheritance of environment only, that is, repetition of similar developmental processes under similar conditions. The bearing of all this on the doctrine of determinants, that characters of the adult are represented by germs of a lesser order in the germ of the entire organism, is obvious.
Many of the problems of heredity, so-called, are not capable at present of such resolution. We may note some instances of this kind and then attempt to analyze the whole matter briefly. The example cited of transplantation of a leg-bud is of this kind: the transplanted leg-bud does not develop into an arm if it be transplanted to the region of the arm, but into a right or left leg, as the case may be, and this is true no matter how early the stage at which the transplantation may be made. It is not possible to change the specificity of such a primordium by any means yet employed. Moreover, there are many other experiments which show that the primordia of a great many structures are definitely specified even before they can be detected by any method of pure observation. Thus if a portion of the medullary plate of a frog embryo be cut out so as to include in the cut part the region that would form an eye in the course of time, and if then this piece be replaced inverted, it is found that the subsequent development of this area is inverted, not restored to the normal, although no trace of organs
