following, and it is one which, if confirmed by future observation, must modify the views recently advanced on the mode of origin, the nature, the properties, and the destination of the nucleus in the physi- ology of cells. It is known that the germinal spot presents, in some instances, a dark point in its centre. The author finds that such a point is invariably present at a certain period ; that it enlarges, and is then found to contain a cavity filled with fluid, which is exceed- ingly pellucid. The outer portion of the spot resolves itself into cells ; and the foundations of other cells come into view in its in- terior, arranged in layers around the central cavity ; the outer layers being pushed forth by the continual origin of new cells in the in- terior. The latter commence as dark globules in the pellucid fluid of the central cavity. Every other nucleus met with in these researches has seemed to be the seat of changes essentially the same. The appearance of the central portion of the nucleus is, from the above process, continually varying ; and the author believes that the nature of the nucleolus of Schleiden is to be thus explained. The germinal vesicle, enlarged and flattened, becomes filled with the objects arising from the changes in its spot ; and the interior of each of the objects filling it, into which the eye can penetrate, pre- sents a repetition of the process above described. The central portion of the altered spot, with its pellucid cavity, remains at that part of the germinal vesicle which is directed towards the surface of the ovum, and towards the surface of the ovary. At the cor- responding part, the thick transparent membrane of the ovum in some instances appears to have become attenuated, in others also cleft. Subsequently, the central portion of the altered spot passes to the centre of the germinal vesicle ; the germinal vesicle, regain- ing its spherical form, returns to the centre of the ovum, and a fissure in the thick transparent membrane is no longer seen. From these successive changes it may be inferred that fecundation has taken place ; and this by the introduction of some substance into the germinal vesicle from the exterior of the ovary. It may also be inferred, that the central portion of the altered germinal spot is the point of fecundation. In further proof that such really is the case, there arise at this part two cells, which constitute the foundation of the new being. These two cells enlarge, and imbibe the fluid of those around them, which are at first pushed further out by the two central cells, and subsequently disappear by liquefaction. The contents of the germinal vesicle thus enter into the formation of two cells. The membrane of the germinal vesicle then disappears by liquefaction.
Each of the succeeding twin cells presents a nucleus, which, having first passed to the centre of its cell, resolves itself into cells in the manner above described. By this means the twin cells, in their turn, become filled with other cells. Only two of these in each twin cell being destined to continue, the others, as well as the membrane of each parent-cell, disappear by liquefaction, when four cells remain. These four produce eight, and so on, until the germ consists of a mulberry-like object, the cells of which do not admit
