- ing the terminations of the secretory nerves, while
pilocarpin produces an opposite effect in a similar way.
On account of these sweat glands the skin becomes next in importance after the kidneys in the excretion of waste products. The quantity of sweat excreted varies greatly and is hard to measure. It is influenced by the temperature and humidity of the surrounding air, by the nature and quantity of food and drink consumed, by the amount of exercise, the relative activity of other organs, especially the kidneys, and by certain mental conditions. The hotter it is, the greater the amount of perspiration. In damp weather there may be less perspiration, but it does not evaporate and is therefore more in evidence.
Ordinarily man has a temperature of 98.6°. The source of this body heat or temperature is the general body metabolism, muscular activity, and activity of the glands, especially of the liver, which is constantly active, the blood in the hepatic vein being warmer than that in any other part of the body. The tissue of the brain also is said to be warmer than the surrounding blood, and the heart and respiratory muscles, which are in constant activity, are responsible for much of the body heat. The amount of heat generated in the body, therefore, varies at different times, according as a person is awake or asleep, quiet or active.
Temperature Regulation.—The temperature is regulated by variations in the production and loss of heat, less being known of its production than of its loss. It has been calculated that four-fifths of the energy of the body is converted into heat, one-fifth into work. As the minimum amount of heat produced in twenty-four hours is sufficient to raise 10 gallons of water from 0° to boiling-point, it is evident that if there were not some way for the escape of much of this heat the body would become hotter and hotter and finally destroy itself. The temperature, however, except on the surface, is uniform, heat being lost as fast as it is produced. For,
