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puscles in the capillaries, had been present in the most perfect conceivable form; but the result had been the very opposite condition.
The explanation of Wharton Jones's mistake became apparent as I proceeded along the path which opened with so much promise. He had never experimented in a perfectly healthy state of the circulation, but had described with great accuracy what could occur only under morbid conditions. For I afterwards learned that the normal temperature of man is deadly to the cold-blooded frog. That animal, which under ordinary conditions exhibits very remarkable persistence of vitality even after somatic death, is killed by being held for about a quarter of an hour in the hand; and if one of its hind feet be similarly warmed, the blood-corpuscles will be found packed and stagnant in the vessels of the webs, as if mustard or any other powerful irritant had been applied to them.
If, on the other hand, in securing the frog for observation under the microscope, scrupulous care was taken to avoid needless exposure of the foot to the warmth of the hands, the threads for fixing the toes being tied by means of long forceps, and each half of the knot done separately, with a fair interval between them, a state of the circulation was seen which is, I believe, even to this day rarely witnessed. The white corpuscles, instead of trailing, more or less sluggishly, along the walls of the venous radicles—the normal condition, according to some modern textbooks—move freely along among the red discs, and
