- sults from the poison entering the blood, and so passing to the
remote organs acted on, or simply arises from the organ remotely affected sympathizing through the medium of the nerves with the impression made on the organ which is affected primarily. On this question precise experiments are still wanted. The general opinion has for some time been that it acts through the blood. And this view has of late been strengthened by indisputable evidence, that the poison does enter the blood, and is diffused by it throughout the body.
For a long period chemists sought in vain for arsenic in the animal tissues and secretions at a distance from the alimentary canal. Such was the position of matters at the date of the last edition of this work; in which the failure was ascribed to the methods of analysis then known not being delicate enough to discover the small quantity of arsenic which disappears by absorption in cases of poisoning.[1] That statement is now referred to, because in a late controversy in France an attempt was made, by an erroneous quotation of this work, to deprive Professor Orfila of the honour, which is due to him alone, of having recently been the first to demonstrate the possibility of detecting arsenic throughout the organs and secretions generally of the bodies of men and animals poisoned with it.
This most important discovery, pregnant alike with interesting physiological deductions and valuable medico-legal applications, was first announced by him to the Parisian Academy of Medicine in January, 1839; when he stated that arsenic is absorbed in such quantity in cases of poisoning as to admit of being discovered by an improved process of analysis in various organs and fluids of the body, such as the liver, spleen, kidneys, muscles, blood, and urine.[2] In November, 1840, he proved these facts to the satisfaction of a committee of the academy.[3] And since then they have been confirmed by others, not merely in express experiments, but likewise in the familiar experience of medico-legal practice. The situations where arsenic is met with in largest quantity are the liver, the spleen, and the urine, but above all the liver. The precise circumstances in which it may be found in one or another of these quarters have not yet been determined. But in most cases of acute arsenical poisoning where the search has been made at all, it has proved successful in the liver. In two late instances I have readily found arsenic by the process of Marsh or Reinsch in the liver after four months' interment.
Since arsenic then is clearly absorbed into the blood, it becomes an interesting question whether the organization of the blood is thereby changed. This question cannot be answered with confidence. But in all probability the blood does undergo some change in its crasis; for in most cases of acute poisoning that fluid is found after death in a remarkable state of fluidity [see Section on the Morbid Appearances]; and Mr. James observed that if venous or arterial
