are now well aware, though not at the time of this trial, that in the very malady alleged by the prisoner to have carried off the deceased, namely dysentery, the administration of calomel in repeated large doses is accounted by many a proper method of cure. The doses purchased by the prisoner were considerably larger, it is true. But there was not any evidence of his having administered his purchases in single doses as he got them; and even though there had been evidence to that effect, it would not remove altogether the difficulty of deciding the question, as to the irritating action of calomel, on which the issue of the trial in one view of the case chiefly depended.
It is probable that all the compounds formed by corrosive sublimate with animal and vegetable substances are feebly poisonous, or at least very much inferior in activity to corrosive sublimate itself. This has been shown by Orfila to be the case with the compound formed by albumen. Sixty grains of this compound, being equivalent to nearly five grains of corrosive sublimate, produced no bad effect whatever on a dog or a rabbit.[1] The same has been satisfactorily proved by Taddei as to the compound formed by gluten. Twelve grains of corrosive sublimate decomposed by his emulsion of gluten had no effect whatever on a dog.[2] It is important to remark, however, that if there be an excess of the decomposing principle, so that the precipitate is party redissolved, the irritant action of the corrosive sublimate is not so much reduced, though it is still certainly diminished. Orfila has settled this point in regard to albumen.[3] The power of producing mercurial erethysm is possessed by all mercurial compounds whatever, and among the rest by the compounds now under consideration.[4]
The present section may now be concluded with a few remarks on the strength of the evidence derived from the symptoms which are produced by the compounds of mercury.
If the medical jurist should meet with a case of sudden death like that of the animals experimented on by Sir B. Brodie, the symptoms alone could not constitute any evidence of poisoning with corrosive sublimate. All he could say would be that this variety of poisoning was possible, but that various natural diseases might have the same effect. This feebleness in the evidence from symptoms, however, is of little moment; because the dose must be great to cause such symptoms, and little can be vomited before death; so that the poison will be certainly found in the stomach.
Should the patient die under symptoms of general irritation in the alimentary canal, poisoning may be suspected. But it would be impossible to derive from them more than presumptive evidence. The suspicion must become strong, however, if the ordinary signs of irritation in the alimentaay canal are attended with the discharge of blood upwards and and downwards. And the presumption will, I appre-*
