may be given without injury to a rabbit,[1] if previously rendered alkaline by ammonia. But, nevertheless, as will be seen under the head of the treatment, ammonia, as Mr. Murray stated, is a good antidote when administered after the poison as a stimulant.
The ferrocyanates, or prussiates, do not possess deleterious properties. These salts were at one time considered compounds of hydrocyanic acid with a double oxidized base, oxide of iron being one. Thus the prussiate of potass was considered a compound of hydrocyanic acid with potass and oxide of iron. But since the investigations of Mr. Porrett, it has been admitted that there is only one base, potash; and that it is in union with a hydracid, called ferrocyanic acid, the radicle of which is a ternary body composed of carbon, azote, and iron. The physiological effects of this substance, which have been examined by many experimentalists, are favourable to Porrett's opinion; for although some have found it poisonous, all agree in assigning it very feeble properties, and some have not been able to discover in it any deleterious quality at all. Coullon observes that Gazan killed a dog with two drachms, and Callies another with three drachms of the salt met with in commerce.[2] Schubarth found that half an ounce had not any material effect on dogs, even when vomiting did not occur for half an hour;[3] and Callies, who found the salt of commerce somewhat poisonous, also remarked, that when it was carefully prepared, several ounces might be given without harm.[4] D'Arcet once swallowed half a pound of a solution without any injury.[5] Similar results were obtained previously with smaller doses by Wollaston, Marcet,[6] and Emmert,[7] as well as afterwards by Dr. Macneven,[8] and Schubarth,[9] who found that a drachm or even two drachms might be taken with impunity by man and the lower animals.
The sulpho-cyanic acid, another substance analogous in chemical nature to the ferrocyanic, was once supposed like it to be a poison of great activity, but this is doubtful. Professor Mayer of Bonn ascertained that a drachm and a half of a moderately strong solution of the acid sometimes killed a rabbit in ninety seconds when injected into the windpipe, and that the same quantity of a solution of sulpho-*cyanate of potassa might occasion death in the course of four hours; but that some rabbits took half an ounce of the former and three drachms of the latter without material harm, both when administered through the windpipe, when injected into the rectum, and when introduced into the stomach by a gullet-tube. In the fatal cases death took place under symptoms of oppressed breathing, rarely attended with convulsions; and extensive traces of irritation were found in the alimentary canal.[10] Dr. Westrumb of Hammeln,
- ↑ Edin. Journal of Science, ii. 215.
- ↑ Recherches, &c. 221.
- ↑ Horn's Archiv für Medizinische Erfahrung, 1827, i. 73.
- ↑ Coullon, 221.
- ↑ Revue Médicale, xvii. 271.
- ↑ Nicholson's Journal, xxxi. 191.
- ↑ Ueber die giftige Wirkungen der unächten Angustura.— Hufeland's Journal, xl. iii. 68.
- ↑ Archives Gén. de Méd. iii. 269.
- ↑ Hufeland's Journal, lii. i. 93.
- ↑ Wibmer. Die Wirkung der Arzneimittel und Gifte, iii. 138, from Harless, Jahrbuch der Medizin, ix. 1.
