English: A: Mean HINscores plotted for different cluster sizes for all networks and random controls. B: Selected gene clusters denoted as B.1, B.2, B.3 and their corresponding HIN subgraphs from the CURATED dataset. In the phenotypically derived gene clusters (upper part) red edges represent physical interactions among the gene products. In the HIN subgraphs (lower part), red edges denote phenotypic relationship among the corresponding genes. Nodes in light blue belong to the phenotypically derived gene clusters that are not present in HIN. B.1 is associated with mitochondrial respiratory chain deficiencies, Leigh and Alexander Disease. B.2 corresponds to Hypertension and Cardiovascular Diseases. B.3 represents different types of Hyperlipoproteinemia. Nodes are colored according to their disease class (see Fig. S4).