ICD-10-CM (2010)/CHAPTER 3

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Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)[edit]

Excludes2: autoimmune disease (systemic) NOS (M35.9)
certain conditions originating in the perinatal period (P00-P96)
complications of pregnancy, childbirth and the puerperium (O00-O99)
congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
endocrine, nutritional and metabolic diseases (E00-E90)
human immunodeficiency virus [HIV] disease (B20)
injury, poisoning and certain other consequences of external causes (S00-T98)
neoplasms (C00-D49)
symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

This chapter contains the following blocks:
D50-D53 Nutritional anemias
D55-D59 Hemolytic anemias
D60-D64 Aplastic and other anemias and other bone marrow failure syndromes
D65-D69 Coagulation defects, purpura and other hemorrhagic conditions
D70-D77 Other disorders of blood and blood-forming organs
D78 Intraoperative and postprocedural complications of spleen
D80-D89 Certain disorders involving the immune mechanism

Nutritional anemias (D50-D53)[edit]

D50 Iron deficiency anemia[edit]

Includes: asiderotic anemia
hypochromic anemia
D50.0 Iron deficiency anemia secondary to blood loss (chronic)
Posthemorrhagic anemia (chronic)
Excludes1: acute posthemorrhagic anemia (D62)

congenital anemia from fetal blood loss (P61.3)
D50.1 Sideropenic dysphagia
Kelly-Paterson syndrome
Plummer-Vinson syndrome
D50.8 Other iron deficiency anemias
Iron deficiency anemia due to inadequate dietary iron intake
D50.9 Iron deficiency anemia, unspecified

D51 Vitamin B12 deficiency anemia[edit]

Excludes1: vitamin B12 deficiency (E53.8)
D51.0 Vitamin B12 deficiency anemia due to intrinsic factor deficiency
Addison anemia
Biermer anemia
Pernicious (congenital) anemia
Congenital intrinsic factor deficiency
D51.1 Vitamin B12 deficiency anemia due to selective vitamin B12 malabsorption with proteinuria
Imerslund (-Gr?sbeck) syndrome
Megaloblastic hereditary anemia
D51.2 Transcobalamin II deficiency
D51.3 Other dietary vitamin B12 deficiency anemia
Vegan anemia
D51.8 Other vitamin B12 deficiency anemias
D51.9 Vitamin B12 deficiency anemia, unspecified

D52 Folate deficiency anemia[edit]

Excludes1: folate deficiency without anemia (E53.8)
D52.0 Dietary folate deficiency anemia
Nutritional megaloblastic anemia
D52.1 Drug-induced folate deficiency anemia
Code first (T36-T50) to identify drug
D52.8 Other folate deficiency anemias
D52.9 Folate deficiency anemia, unspecified
Folic acid deficiency anemia NOS

D53 Other nutritional anemias[edit]

Includes: megaloblastic anemia unresponsive to vitamin B12 or folate therapy
D53.0 Protein deficiency anemia
Amino-acid deficiency anemia
Orotaciduric anemia
Excludes1: Lesch-Nyhan syndrome (E79.1)
D53.1 Other megaloblastic anemias, not elsewhere classified
Megaloblastic anemia NOS
Excludes1: Di Guglielmo's disease (C94.0)
D53.2 Scorbutic anemia
Excludes1: scurvy (E54)
D53. 8 Other specified nutritional anemias
Anemia associated with deficiency of copper
Anemia associated with deficiency of molybdenum
Anemia associated with deficiency of zinc
Excludes1: nutritional deficiencies without anemia, such as:
copper deficiency NOS (E61.0)
molybdenum deficiency NOS (E61.5)
zinc deficiency NOS (E60)
D53.9 Nutritional anemia, unspecified
Simple chronic anemia
Excludes1: anemia NOS (D64.9)

Hemolytic anemias (D55-D59)[edit]

D55 Anemia due to enzyme disorders[edit]

Excludes1: drug-induced enzyme deficiency anemia (D59.2)
D55.0 Anemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
G6PD deficiency anemia
D55.1 Anemia due to other disorders of glutathione metabolism
Anemia (due to) enzyme deficiencies, except G6PD, related to the hexose monophosphate [HMP] shunt pathway
Anemia (due to) hemolytic nonspherocytic (hereditary), type I
D55.2 Anemia due to disorders of glycolytic enzymes
Hemolytic nonspherocytic (hereditary) anemia, type II
Hexokinase deficiency anemia
Pyruvate kinase [PK] deficiency anemia
Triose-phosphate isomerase deficiency anemia
Excludes1: disorders of glycolysis not associated with anemia (E74.8)
D55.3 Anemia due to disorders of nucleotide metabolism
D55.8 Other anemias due to enzyme disorders
D55.9 Anemia due to enzyme disorder, unspecified
D56 Thalassemia
Excludes1: sickle-cell thalassemia (D57.4-)

D56.0 Alpha thalassemia[edit]

Alpha thalassemia major
Hemoglobin H disease
Severe alpha thalassemia
Triple gene defect alpha thalassemia
Excludes1: alpha thalassemia minor (D56.3)
asymptomatic alpha thalassemia (D56.3)
hydrops fetalis due to hemolytic disease (P56.-)
D56.1 Beta thalassemia
Beta thalassemia major
Cooley' s anemia
Homozygous beta thalassemia
Severe beta thalassemia
Thalassemia intermedia
Excludes1: beta thalassemia minor (D56.3)
delta-beta thalassemia (D56.2)
sickle-cell beta thalassemia (D57.4-)
D56.2 Delta-beta thalassemia
Homozygous delta-beta thalassemia
Excludes1: delta-beta thalassemia minor (D56.3)
D56.3 Thalassemia minor
Alpha thalassemia minor
Alpha thalassemia trait
Beta thalassemia minor
Delta-beta thalassemia minor
Excludes1: alpha thalassemia (D56.0)
beta thalassemia (D56.1)
delta-beta thalassemia (D56.2)
D56.4 Hereditary persistence of fetal hemoglobin [HPFH]
D56.8 Other thalassemias
Hb-Bart's disease
Excludes1: sickle cell anemia (D57.-)
sickle-cell thalassemia (D57.4)
D56.9 Thalassemia, unspecified
Mediterranean anemia (with other hemoglobinopathy)
Thalassemia (minor) (mixed) (with other hemoglobinopathy)

D57 Sickle-cell disorders[edit]

Use additional code for any associated fever (R50.81)
Excludes1: other hemoglobinopathies (D58.-)
D57.0 Hb-SS disease with crisis
Sickle-cell disease NOS with crisis
Hb-SS disease with vasoocclusive pain
D57.00 Hb-SS disease with crisis, unspecified
D57.01 Hb-SS disease with acute chest syndrome
D57.02 Hb-SS disease with splenic sequestration
D57.1 Sickle-cell disease without crisis
Hb-SS disease without crisis
Sickle-cell anemia NOS
Sickle-cell disease NOS
Sickle-cell disorder NOS
D57.2 Sickle-cell/Hb-C disease
Hb-SC disease
Hb-S/Hb-C disease
D57.20 Sickle-cell/Hb-C disease without crisis
D57.21 Sickle-cell/Hb-C disease with crisis
D57. 211 Sickle-cell/Hb-C disease with acute chest syndrome
D57.212 Sickle-cell/Hb-C disease with splenic sequestration
D57.219 Sickle-cell/Hb-C disease with crisis, unspecified
Sickle-cell/Hb-C disease with crisis NOS
D57.3 Sickle-cell trait
Hb-S trait
Heterozygous hemoglobin S
D57.4 Sickle-cell thalassemia
Sickle-cell beta thalassemia
Thalassemia Hb-S disease
D57.40 Sickle-cell thalassemia without crisis
Sickle-cell thalassemia NOS
D57.41 Sickle-cell thalassemia with crisis
Sickle-cell thalassemia with vasoocclusive pain
D57.411 Sickle-cell thalassemia with acute chest syndrome
D57.412 Sickle-cell thalassemia with splenic sequestration
D57.419 Sickle-cell thalassemia with crisis, unspecified
Sickle-cell thalassemia with crisis NOS
D57.8 Other sickle-cell disorders
Hb-SD disease
Hb-SE disease
D57.80 Other sickle-cell disorders without crisis
D57.81 Other sickle-cell disorders with crisis
D57.811 Other sickle-cell disorders with acute chest syndrome
D57.812 Other sickle-cell disorders with splenic sequestration
D57.819 Other sickle-cell disorders with crisis, unspecified
Other sickle-cell disorders with crisis NOS

D58 Other hereditary hemolytic anemias[edit]

Excludes1: hemolytic anemia of the newborn (P55.-)
D58.0 Hereditary spherocytosis
Acholuric (familial) jaundice
Congenital (spherocytic) hemolytic icterus
Minkowski-Chauffard syndrome
D58.1 Hereditary elliptocytosis
Elliptocytosis (congenital)
Ovalocytosis (congenital) (hereditary)
D58.2 Other hemoglobinopathies
Abnormal hemoglobin NOS
Congenital Heinz body anemia
Hb-C disease
HbD disease
Hb-E disease
Hemoglobinopathy NOS
Unstable hemoglobin hemolytic disease
Excludes1: familial polycythemia (D75.0)
Hb-M disease (D74.0)
hereditary persistence of fetal hemoglobin [HPFH] (D56.4)
high-altitude polycythemia (D75.1)
methemoglobinemia (D74.-)
D58.8 Other specified hereditary hemolytic anemias
D58.9 Hereditary hemolytic anemia, unspecified

D59 Acquired hemolytic anemia[edit]

D59.0 Drug-induced autoimmune hemolytic anemia
Code first (T36-T50) to identify drug
D59.1 Other autoimmune hemolytic anemias
Autoimmune hemolytic disease (cold type) (warm type)
Chronic cold hemagglutinin disease
Cold agglutinin disease
Cold agglutinin hemoglobinuria
Cold type (secondary) (symptomatic) hemolytic anemia
Warm type (secondary) (symptomatic) hemolytic anemia
Excludes1: Evans syndrome (D69.41)
hemolytic disease of newborn (P55.-)
paroxysmal cold hemoglobinuria (D59.6)
D59.2 Drug-induced nonautoimmune hemolytic anemia
Drug-induced enzyme deficiency anemia
Code first (T36-T50) to identify drug
D59.3 Hemolytic-uremic syndrome
D59.4 Other nonautoimmune hemolytic anemias
Mechanical hemolytic anemia
Microangiopathic hemolytic anemia
Toxic hemolytic anemia
D59.5 Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]
Excludes1: hemoglobinuria NOS (R82.3)
D59.6 Hemoglobinuria due to hemolysis from other external causes
Hemoglobinuria from exertion
March hemoglobinuria
Paroxysmal cold hemoglobinuria
Use additional code (Chapter 20) to identify external cause
Excludes1: hemoglobinuria NOS (R82.3)
D59.8 Other acquired hemolytic anemias
D59.9 Acquired hemolytic anemia, unspecified
Idiopathic hemolytic anemia, chronic

Aplastic and other anemias and other bone marrow failure syndromes (D60-D64)

D60 Acquired pure red cell aplasia [erythroblastopenia][edit]

Includes: red cell aplasia (acquired) (adult) (with thymoma)
Excludes1: congenital red cell aplasia (D61.01)
D60.0 Chronic acquired pure red cell aplasia
D60.1 Transient acquired pure red cell aplasia
D60.8 Other acquired pure red cell aplasias
D60.9 Acquired pure red cell aplasia, unspecified

D61 Other aplastic anemias and other bone marrow failure syndromes[edit]

Excludes1: neutropenia (D70.-)
D61.0 Constitutional aplastic anemia
D61.01 Constitutional (pure) red blood cell aplasia
Excludes1: acquired red cell aplasia (D60.9)
Blackfan-Diamond syndrome
Congenital (pure) red cell aplasia
Familial hypoplastic anemia
Primary (pure) red cell aplasia
Red cell (pure) aplasia of infants
D61.09 Other constitutional aplastic anemia
Fanconi's anemia
Pancytopenia with malformations
D61.1 Drug-induced aplastic anemia
Code first (T36-T50) to identify drug
D61.2 Aplastic anemia due to other external agents
Code first (T51-T65) to identify cause
D61.3 Idiopathic aplastic anemia
D61.8 Other specified aplastic anemias and other bone marrow failure syndromes
D61.81 Pancytopenia
Excludes1: pancytopenia (due to) (with):
aplastic anemia (D61.-)
bone marrow infiltration (D61.82)
congenital (pure) red cell aplasia (D61.01)
drug induced (D61.1)
hairy cell leukemia (C91.4-)
human immunodeficiency virus disease (B20.-)
leukoerythroblastic anemia (M61.82)
myelodysplastic syndromes (D46.-)
myeloproliferative disease (D47.1)
D61.82 Myelophthisis
Leukoerythroblastic anemia
Myelophthisic anemia
Code also the underlying disorder, such as:
malignant neoplasm of breast (C50.-)
tuberculosis (A15.-)
Excludes1: idiopathic myelofibrosis (D47.1)
myelofibrosis NOS (D75.81)
myelofibrosis with myeloid metaplasia (D47.4)
primary myelofibrosis (D47.1)
secondary myelofibrosis (D75.81)
D61.89 Other specified aplastic anemias and other bone marrow failure syndromes
D61.9 Aplastic anemia, unspecified
Hypoplastic anemia NOS
Medullary hypoplasia

D62 Acute posthemorrhagic anemia[edit]

Excludes1: anemia due to chronic blood loss (D50.0)
blood loss anemia NOS (D50.0)
congenital anemia from fetal blood loss (P61.3)

D63 Anemia in chronic diseases classified elsewhere[edit]

D63.0 Anemia in neoplastic disease
Code first neoplasm (C00-D49)
Excludes1: anemia due to antineoplastic chemotherapy (D64.81)
D63.1 Anemia in chronic kidney disease
Erythropoietin resistant anemia (EPO resistant anemia)
Code first underlying chronic kidney disease (CKD) (N18.-)
D63.8 Anemia in other chronic diseases classified elsewhere
Code first underlying disease, such as:
diphyllobothriasis (B70.0)
hookworm disease (B76.0-B76.9)
hypothyroidism (E00.0-E03.9)
malaria (B50.0-B54)
symptomatic late syphilis (A52.79)
tuberculosis (A18.89)

D64 Other anemias[edit]

Excludes1: refractory anemia (D46.-)
D64.0 Hereditary sideroblastic anemia
Sex-linked hypochromic sideroblastic anemia
D64.1 Secondary sideroblastic anemia due to disease
Code first underlying disease
D64.2 Secondary sideroblastic anemia due to drugs and toxins
Code first (T36-T65) to identify drug or toxin
D64. 3 Other sideroblastic anemias
Sideroblastic anemia NOS
Pyridoxine-responsive sideroblastic anemia NEC
D64.4 Congenital dyserythropoietic anemia
Dyshematopoietic anemia (congenital)
Excludes1: Blackfan-Diamond syndrome (D61.01)
Di Guglielmo's disease (C94.0)
D64.8 Other specified anemias
D64.81 Anemia due to antineoplastic chemotherapy
Antineoplastic chemotherapy induced anemia
Excludes1: anemia in neoplastic disease (D63.0)
aplastic anemia due to antineoplastic chemotherapy (D61.1)
D64.89 Other specified anemias
Infantile pseudoleukemia
D64.9 Anemia, unspecified

Coagulation defects, purpura and other hemorrhagic conditions (D65-D69)[edit]

D65 Disseminated intravascular coagulation [defibrination syndrome][edit]

Includes: afibrinogenemia, acquired
consumption coagulopathy
diffuse or disseminated intravascular coagulation [DIC]
fibrinolytic hemorrhage, acquired
fibrinolytic purpura
purpura fulminans
Excludes1: disseminated intravascular coagulation (complicating):
abortion or ectopic or molar pregnancy (O00-O07, O08.1)
in newborn (P60)
pregnancy, childbirth and the puerperium (O45.0, O46.0, O67.0, O72.3)

D66 Hereditary factor VIII deficiency[edit]

Includes: classical hemophilia
deficiency factor VIII (with functional defect)
hemophilia NOS
hemophilia A
Excludes1: factor VIII deficiency with vascular defect (D68.0)

D67 Hereditary factor IX deficiency[edit]

Includes: christmas disease
factor IX deficiency (with functional defect)
hemophilia B
plasma thromboplastin component [PTC] deficiency

D68 Other coagulation defects[edit]

Excludes1: abnormal coagulation profile (R79.1)
coagulation defects complicating:
abortion or ectopic or molar pregnancy (O00-O07, O08.1)
pregnancy, childbirth and the puerperium (O45.0, O46.0, O67.0, O72.3)

D68.0 Von Willebrand's disease[edit]

Factor VIII deficiency with vascular defect
Vascular hemophilia
Excludes1: capillary fragility (hereditary) (D69.8)
factor VIII deficiency NOS (D66)
factor VIII deficiency with functional defect (D66)
D68.1 Hereditary factor XI deficiency
Hemophilia C
Plasma thromboplastin antecedent [PTA] deficiency
Rosenthal?s disease
D68.2 Hereditary deficiency of other clotting factors
AC globulin deficiency
Congenital afibrinogenemia
Deficiency of factor I [fibrinogen]
Deficiency of factor II [prothrombin]
Deficiency of factor V [labile]
Deficiency of factor VII [stable]
Deficiency of factor X [Stuart-Prower]
Deficiency of factor XII [Hageman]
Deficiency of factor XIII [fibrin stabilizing]
Dysfibrinogenemia (congenital)
Owren's disease
Proaccelerin deficiency
D68.3 Hemorrhagic disorder due to circulating anticoagulants
D68.31 Hemorrhagic disorder due to intrinsic circulating anticoagulants
Hemorrhagic disorder due to intrinsic increase in antithrombin
Hemorrhagic disorder due to intrinsic increase in anti-VIIIa
Hemorrhagic disorder due to intrinsic increase in anti-IXa
Hemorrhagic disorder due to intrinsic increase in anti-Xa
Hemorrhagic disorder due to intrinsic increase in anti-XIa
D68.32 Hemorrhagic disorder due to extrinsic circulating anticoagulants
Drug-induced hemorrhagic disorder
Code first (T45.5-) to identify any administered anticoagulant
D68.4 Acquired coagulation factor deficiency
Deficiency of coagulation factor due to liver disease
Deficiency of coagulation factor due to vitamin K deficiency
Excludes1: vitamin K deficiency of newborn (P53)
D68.5 Primary thrombophilia
Primary hypercoagulable states
Excludes1: lupus anticoagulant (D68.62)
thrombotic thrombocytopenic purpura (M31.1)
D68.51 Activated protein C resistance
Factor V Leiden mutation
D68.52 Prothrombin gene mutation
D68.59 Other primary thrombophilia
Antithrombin III deficiency
Hypercoagulable state NOS
Primary hypercoagulable state NEC
Primary thrombophilia NEC
Protein C deficiency
Protein S deficiency
Thrombophilia NOS
D68.6 Other thrombophilia
Other hypercoagulable states
Excludes1: diffuse or disseminated intravascular coagulation [DIC] (D65)
heparin induced thrombocytopenia (HIT) (D75.82)
hyperhomocysteinemia (E72.11)
D68.61 Anticardiolipin syndrome
Antiphospholipid syndrome
Excludes1: lupus anticoagulant syndrome (D68.62)
D68.62 Lupus anticoagulant syndrome
Lupus anticoagulant
Presence of systemic lupus erythematosus [SLE] inhibitor
Excludes1: anticardiolipin syndrome (D68.61)
antiphospholipid syndrome (D68.61)
D68.69 Other thrombophilia
Hypercoagulable states NEC
Secondary hypercoagulable state NOS
D68.8 Other specified coagulation defects
Excludes1: hemorrhagic disease of newborn (P53)
D68.9 Coagulation defect, unspecified

D69 Purpura and other hemorrhagic conditions[edit]

Excludes1: benign hypergammaglobulinemic purpura (D89.0)
cryoglobulinemic purpura (D89.1)
essential (hemorrhagic) thrombocythemia (D47.3)
hemorrhagic thrombocythemia (D47.3)
purpura fulminans (D65)
thrombotic thrombocytopenic purpura (M31.1)
Waldenström's hypergammaglobulinemic purpura (D89.0)
D69. 0 Allergic purpura
Allergic vasculitis
Nonthrombocytopenic hemorrhagic purpura
Nonthrombocytopenic idiopathic purpura
Purpura anaphylactoid
Purpura Henoch(-Sch?nlein)
Purpura rheumatica
Vascular purpura
Excludes1: thrombocytopenic hemorrhagic purpura (D69.3)
D69.1 Qualitative platelet defects
Bernard-Soulier [giant platelet] syndrome
Glanzmann's disease
Grey platelet syndrome
Thromboasthenia (hemorrhagic) (hereditary)
Excludes1: von Willebrand's disease (D68.0)
D69.2 Other nonthrombocytopenic purpura
Purpura NOS
Purpura simplex
Senile purpura
D69.3 Immune thrombocytopenic purpura
Hemorrhagic (thrombocytopenic) purpura
Idiopathic thrombocytopenic purpura
Tidal platelet dysgenesis
D69.4 Other primary thrombocytopenia
Excludes1: transient neonatal thrombocytopenia (P61.0)
Wiskott-Aldrich syndrome (D82.0)
D69.41 Evans syndrome
D69.42 Congenital and hereditary thrombocytopenia purpura
Congenital thrombocytopenia
Hereditary thrombocytopenia
Code first: congential or hereditary disorder, such as:
thrombocytopenia with absent radius (TAR syndrome) (Q87.2)
D69.49 Other primary thrombocytopenia
Megakaryocytic hypoplasia
Primary thrombocytopenia NOS
D69.5 Secondary thrombocytopenia
Excludes1: heparin induced thrombocytopenia (HIT) (D75.82)
transient thrombocytopenia of newborn (P61.0)
D69.6 Thrombocytopenia, unspecified
D69.8 Other specified hemorrhagic conditions
Capillary fragility (hereditary)
Vascular pseudohemophilia
D69.9 Hemorrhagic condition, unspecified

Other disorders of blood and blood-forming organs (D70-D77)

D70 Neutropenia[edit]

Includes: agranulocytosis
decreased absolute neurophile count (ANC)
Use additional code for any associated:
fever (R50.81)
mucositis (J34.81, K12.3-, K12.4, K92.81, N76.81)
Excludes1: neutropenic splenomegaly (D73.81)
transient neonatal neutropenia (P61.5)
D70.0 Congenital agranulocytosis
Congenital neutropenia
Infantile genetic agranulocytosis
Kostmann's disease
D70.1 Agranulocytosis secondary to cancer chemotherapy
Code first (T45.1-) to identify drug
Code also underlying neoplasm
D70.2 Other drug-induced agranulocytosis
Code first (T36-T50) to identify drug
D70.3 Neutropenia due to infection
D70.4 Cyclic neutropenia
Cyclic hematopoiesis
Periodic neutropenia
D70.8 Other neutropenia
D70.9 Neutropenia, unspecified

D71 Functional disorders of polymorphonuclear neutrophils[edit]

Includes: cell membrane receptor complex [CR3] defect
chronic (childhood) granulomatous disease
congenital dysphagocytosis
progressive septic granulomatosis

D72 Other disorders of white blood cells[edit]

Excludes1: basophilia (D72.824)
immunity disorders (D80-D89)
neutropenia (D70)
preleukemia (syndrome) (D46.9)
D72.0 Genetic anomalies of leukocytes
Alder (granulation) (granulocyte) anomaly
Alder syndrome
Hereditary leukocytic hypersegmentation
Hereditary leukocytic hyposegmentation
Hereditary leukomelanopathy
May-Hegglin (granulation) (granulocyte) anomaly
May-Hegglin syndrome
PelgerHu?t (granulation) (granulocyte) anomaly
Pelger-Hu?t syndrome
Excludes1: Chediak (-Steinbrinck)-Higashi syndrome (E70.330)
D72.1 Eosinophilia
Allergic eosinophilia
Hereditary eosinophilia
Excludes1: Löffler's syndrome (J82)
pulmonary eosinophilia (J82)
D72.8 Other specified disorders of white blood cells
Excludes1: leukemia (C91-C95)
D72.81 Decreased white blood cell count
Excludes1: neutropenia (D70.-)
D72.810 Lymphocytopenia
Decreased lymphocytes
D72.818 Other decreased white blood cell count
Basophilic leukopenia
Eosinophilic leukopenia
Other decreased leukocytes
D72.819 Decreased white blood cell count, unspecified
Decreased leukocytes, unspecified
Leukocytopenia, unspecified
Excludes1: malignant leukopenia (D70.9)
D72.82 Elevated white blood cell count
Excludes1: eosinophilia (D72.1)
D72.820 Lymphocytosis (symptomatic)
Elevated lymphocytes
D72.821 Monocytosis (symptomatic)
Excludes1: infectious mononucleosis (B27.-)
D72.822 Plasmacytosis
D72.823 Leukemoid reaction
Basophilic leukemoid reaction
Leukemoid reaction NOS
Lymphocytic leukemoid reaction
Monocytic leukemoid reaction
Myelocytic leukemoid reaction
Neutrophilic leukemoid reaction
D72.824 Basophilia
D72.825 Bandemia
Bandemia without diagnosis of specific infection
Excludes1: confirmed infection - code to infection
leukemia (C91.-, C92.-, C93.-, C94.-, C95.-)
D72.828 Other elevated white blood cell count
D72.829 Elevated white blood cell count, unspecified
Elevated leukocytes, unspecified
Leukocytosis, unspecified
D72.89 Other specified disorders of white blood cells
Abnormality of white blood cells NEC
D72.9 Disorder of white blood cells, unspecified
Abnormal leukocyte differential NOS

D73 Diseases of spleen[edit]

D73.0 Hyposplenism
Atrophy of spleen
Excludes1: asplenia (congenital) (Q89.01)
postsurgical absence of spleen (Z90.81)
D73.1 Hypersplenism
Excludes1: neutropenic splenomegaly (D73.81)
primary splenic neutropenia (D73.81)
splenitis, splenomegaly in late syphilis (A52.79)
splenitis, splenomegaly in tuberculosis (A18.85)
splenomegaly NOS (R16.1)
splenomegaly congenital (Q89.0)
D73.2 Chronic congestive splenomegaly
D73.3 Abscess of spleen
D73.4 Cyst of spleen
D73.5 Infarction of spleen
Splenic rupture, nontraumatic
Torsion of spleen
Excludes1: rupture of spleen due to Plasmodium vivax malaria (B51.0)
traumatic rupture of spleen (S36.03-)
D73.8 Other diseases of spleen
D73.81 Neutropenic splenomegaly
Werner-Schultz disease
D73.89 Other diseases of spleen
Fibrosis of spleen NOS
Splenitis NOS
D73.9 Disease of spleen, unspecified

D74 Methemoglobinemia[edit]

D74.0 Congenital methemoglobinemia
Congenital NADH-methemoglobin reductase deficiency
Hemoglobin-M [Hb-M] disease
Methemoglobinemia, hereditary
D74.8 Other methemoglobinemias
Acquired methemoglobinemia (with sulfhemoglobinemia)
Toxic methemoglobinemia
D74.9 Methemoglobinemia, unspecified

D75 Other and unspecified diseases of blood and blood-forming organs[edit]

Excludes2: acute lymphadenitis (L04.-)
chronic lymphadenitis (I88.1)
enlarged lymph nodes (R59.-)
hypergammaglobulinemia NOS (D89.2)
lymphadenitis NOS (I88.9)
mesenteric lymphadenitis (acute) (chronic) (I88.0)
D75.0 Familial erythrocytosis
Benign polycythemia
Familial polycythemia
Excludes1: hereditary ovalocytosis (D58.1)
D75.1 Secondary polycythemia
Acquired polycythemia
Emotional polycythemia
Erythrocytosis NOS
Hypoxemic polycythemia
Nephrogenous polycythemia
Polycythemia due to erythropoietin
Polycythemia due to fall in plasma volume
Polycythemia due to high altitude
Polycythemia due to stress
Polycythemia NOS
Relative polycythemia
Excludes1: polycythemia neonatorum (P61.1)
polycythemia vera (D45)
D75.8 Other specified diseases of blood and blood-forming organs
D75.81 Myelofibrosis
Myelofibrosis NOS
Secondary myelofibrosis NOS
Code first the underlying disorder, such as:
malignant neoplasm of breast (C50.-)
Use additional code, if applicable, for associated therapy-related myelodysplastic syndrome (D46.-)
Use additional external cause code, if due to antineoplastic chemotherapy (T45.1-)
Excludes1: acute myelofibrosis (C94.4-)
idiopathic myelofibrosis (D47.1)
leukoerythroblastic anemia (D61.82)
myelofibrosis with myeloid metaplasia (D47.4)
myelophthisic anemia (D61.82)
myelophthisis (D61.82)
primary myelofibrosis (D47.1)
D75.82 Heparin induced thrombocytopenia (HIT)
D75.89 Other specified diseases of blood and blood-forming organs
D75.9 Disease of blood and blood-forming organs, unspecified

D76 Other specified diseases with participation of lymphoreticular and reticulohistiocytic tissue[edit]

Excludes1: (Abt-) Letterer-Siwe disease (C96.0)
eosinophilic granuloma (C96.6)
Hand-Schüller-Christian disease (C96.5)
histiocytic sarcoma (C96.a)
histiocytosis X, multifocal (C96.5)
histiocytosis X, unifocal (C96.6)
malignant histiocytosis (C96.a)
Langerhans-cell histiocytosis, multifocal (C96.5)
Langerhans-cell histiocytosis NOS (C96.6)
Langerhans-cell histiocytosis, unifocal (C96.6)
leukemic reticuloendotheliosis or reticulosis (C91.4-)
lipomelanotic reticuloendotheliosis or reticulosis (I89.8)
D76.1 Hemophagocytic lymphohistiocytosis
Familial hemophagocytic reticulosis
Histiocytoses of mononuclear phagocytes
D76.2 Hemophagocytic syndrome, infection-associated
Use additional code to identify infectious agent or disease.
D76.3 Other histiocytosis syndromes
Reticulohistiocytoma (giant-cell)
Sinus histiocytosis with massive lymphadenopathy

D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere[edit]

Code first underlying disease, such as:
amyloidosis (E85.-)
congenital early syphilis (A50.0)
echinococcosis (B67.0-B67.9)
malaria (B50.0-B54)
schistosomiasis [bilharziasis] (B65.0-B65.9)
vitamin C deficiency (E54)
Excludes1: rupture of spleen due to Plasmodium vivax malaria (B51.0)
splenitis, splenomegaly in:
late syphilis (A52.79)
tuberculosis (A18.85)

Intraoperative and postprocedural complications of the spleen (D78)

D78 Intraoperative and postprocedural complications of the spleen[edit]

D78.0 Intraoperative hemorrhage and hematoma of spleen complicating a procedure
Excludes1: intraoperative hemorrhage and hematoma of spleen due to accidental puncture or laceration during a procedure (D78.1-)
D78.01 Intraoperative hemorrhage and hematoma of spleen complicating a procedure on the spleen
D78.02 Intraoperative hemorrhage and hematoma of spleen complicating other procedure
D78.1 Accidental puncture and laceration of spleen during a procedure
D78.11 Accidental puncture and laceration of spleen during a procedure on the spleen
D78.12 Accidental puncture and laceration of spleen during other procedure
D78.2 Postprocedural hemorrhage and hematoma of spleen following a procedure
D78.21 Postprocedural hemorrhage and hematoma of spleen following a procedure on the spleen
D78.22 Postprocedural hemorrhage and hematoma of spleen following other procedure
D78.8 Other intraoperative and postprocedural complications of spleen
Use additional code, if applicable, to further specify disorder
D78.81 Other intraoperative complications of spleen
D78.89 Other postprocedural complications of spleen

Certain disorders involving the immune mechanism (D80-D89)[edit]

Includes: defects in the complement system
immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
Excludes1: autoimmune disease (systemic) NOS (M35.9)
functional disorders of polymorphonuclear neutrophils (D71)
human immunodeficiency virus [HIV] disease (B20)

D80 Immunodeficiency with predominantly antibody defects[edit]

D80.0 Hereditary hypogammaglobulinemia
Autosomal recessive agammaglobulinemia (Swiss type)
X-linked agammaglobulinemia [Bruton] (with growth hormone deficiency)
D80.1 Nonfamilial hypogammaglobulinemia
Agammaglobulinemia with immunoglobulin-bearing B-lymphocytes
Common variable agammaglobulinemia [CVAgamma]
Hypogammaglobulinemia NOS
D80.2 Selective deficiency of immunoglobulin A [IgA]
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
D80.4 Selective deficiency of immunoglobulin M [IgM]
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia
D80.7 Transient hypogammaglobulinemia of infancy
D80.8 Other immunodeficiencies with predominantly antibody defects
Kappa light chain deficiency
D80.9 Immunodeficiency with predominantly antibody defects, unspecified

D81 Combined immunodeficiencies[edit]

Excludes1: autosomal recessive agammaglobulinemia (Swiss type) (D80.0)
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
D81.3 Adenosine deaminase [ADA] deficiency
D81.4 Nezelof's syndrome
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
D81.6 Major histocompatibility complex class I deficiency
Bare lymphocyte syndrome
D81.7 Major histocompatibility complex class II deficiency
D81.8 Other combined immunodeficiencies
D81.81 Biotin-dependent carboxylase deficiency
Multiple carboxylase deficiency
Excludes1: biotin-dependent carboxylase deficiency due to dietary deficiency of biotin (E53.8)
D81.810 Biotinidase deficiency
D81.818 Other biotin-dependent carboxylase deficiency
Holocarboxylase synthetase deficiency
Other multiple carboxylase deficiency
D81.819 Biotin-dependent carboxylase deficiency, unspecified
Multiple carboxylase deficiency, unspecified
D81. 89 Other combined immunodeficiencies
D81.9 Combined immunodeficiency, unspecified
Severe combined immunodeficiency disorder [SCID] NOS

D82 Immunodeficiency associated with other major defects[edit]

Excludes1: ataxia telangiectasia [Louis-Bar] (G11.3)
D82.0 Wiskott-Aldrich syndrome
Immunodeficiency with thrombocytopenia and eczema
D82.1 Di George's syndrome
Pharyngeal pouch syndrome
Thymic alymphoplasia
Thymic aplasia or hypoplasia with immunodeficiency
D82.2 Immunodeficiency with short-limbed stature
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
X-linked lymphoproliferative disease
D82.4 Hyperimmunoglobulin E [IgE] syndrome
D82.8 Immunodeficiency associated with other specified major defects
D82.9 Immunodeficiency associated with major defect, unspecified

D83 Common variable immunodeficiency[edit]

D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
D83.8 Other common variable immunodeficiencies
D83.9 Common variable immunodeficiency, unspecified

D84 Other immunodeficiencies[edit]

D84.0 Lymphocyte function antigen-1 [LFA-1] defect
D84.1 Defects in the complement system
C1 esterase inhibitor [C1-INH] deficiency
D84.8 Other specified immunodeficiencies
D84.9 Immunodeficiency, unspecified

D86 Sarcoidosis[edit]

D86.0 Sarcoidosis of lung
D86.1 Sarcoidosis of lymph nodes
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
D86.3 Sarcoidosis of skin
D86.8 Sarcoidosis of other sites
D86.81 Sarcoid meningitis
D86.82 Multiple cranial nerve palsies in sarcoidosis
D86.83 Sarcoid iridocyclitis
D86. 84 Sarcoid pyelonephritis
Tubulo-interstitial nephropathy in sarcoidosis
D86.85 Sarcoid myocarditis
D86.86 Sarcoid arthropathy
Polyarthritis in sarcoidosis
D86.87 Sarcoid myositis
D86.89 Sarcoidosis of other sites
Hepatic granuloma
Uveoparotid fever [Heerfordt]
D86.9 Sarcoidosis, unspecified

D89 Other disorders involving the immune mechanism, not elsewhere classified[edit]

Excludes1: hyperglobulinemia NOS (R77.1)
monoclonal gammopathy (of undetermined significance) (D47.2)
Excludes2: transplant failure and rejection (T86.-)
D89.0 Polyclonal hypergammaglobulinemia
Benign hypergammaglobulinemic purpura
Polyclonal gammopathy NOS
D89.1 Cryoglobulinemia
Cryoglobulinemic purpura
Cryoglobulinemic vasculitis
Essential cryoglobulinemia
Idiopathic cryoglobulinemia
Mixed cryoglobulinemia
Primary cryoglobulinemia
Secondary cryoglobulinemia
D89.2 Hypergammaglobulinemia, unspecified
D89.3 Immune reconstitution syndrome
Code first (T36-T50) to identify drug, if drug induced
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
D89.81 Graft-versus-host disease
Code first underlying cause, such as:
complications of transplanted organs and tissue (T86.-)
complications of blood transfusion (T80.89)
Use additional code to identify associated manifestations, such as:
desquamative dermatitis (L30.8)
diarrhea (R19.7)
elevated bilirubin (R17)
hair loss (L65.9)
D89.810 Acute graft-versus-host disease
D89.811 Chronic graft-versus-host disease
D89.812 Acute on chronic graft-versus-host disease
D89. 813 Graft-versus-host disease, unspecified
D89.82 Autoimmune lymphoproliferative syndrome [ALPS]
D89.89 Other specified disorders involving the immune mechanism, not elsewhere classified
Excludes1: human immunodeficiency virus disease (B20)
D89.9 Disorder involving the immune mechanism, unspecified
Immune diseaseNOS