8 LOUIS A. DUHRING;
cular coat ; also a section from the bladder, embracing apparently healthy tissue as well as the patch.
The specimens, as before, were frozen and cut with the microtome, and examined in an indifferent fluid.
The tumor of the leg exhibited precisely the same structure as was found in connection with other similar cutaneous lesions, as described in the former report. The transitional line between the border of the growth and apparently healthy skin was very imperfectly defined under the microscope. Nowhere could a sharp line of demarcation be found. Numerous cellular elements, more or less disseminated, were observed to exist in tissue which to the naked eye appeared sound.
The piece removed from the old abdominal lesion still showed abundant traces of disease in the form of cellular infiltration, far more than would be expected from the external appearance to the naked eye. When this portion of integument was excised it was thought likely that nothing beyond a general thickening together with a deposition of pigment would be observed. An unusual amount of pigment was, however, not discernible with the micro- scope.
The capsule of the cervical gland was thickened as is ordinarily the case in hyperplastic glands. The glands were crowded with the same sort of cells as were found in the skin and other parts, consti- tuting a very dense uniform infiltration.
The tubuli and acini of the parotid gland were seen in some places presenting normal appearances, the cells lining which showed no marked changes ; at other points the acini seemed compressed. The greater part of the mass was uniformly infiltrated with cells identical with those existing in the cervical gland, skin, and else- where. This infiltration extended close up to- the acini and tubuli, and at the surface was found in the adipose tissue.
Nothing markedly abnormal was found about the heart. The muscular tissue, however, Avas fatty; and corpuscular elements were unusually numerous in the connective tissue and some were also dis- covered between the bands of muscular tissue.
The cells of the liver were undergoing fatty atrophy, and there was a slight increase of connective tissue in the portal canals. There was no evidence of corpuscular infiltration either in the connective tissue or in the liver cells ; nor were there anywhere aggregations of new cells.
No positive organic change in the stomach, except a slight fatty atrophy in the walls of the tubuli, could be detected. There were no infiltrations.
In the bladder, the lesion which has been referred to and described, was seen to be a somewhat circumscribed infiltration, manifestly of the same general character as those found on the cutaneous surface. The formation was thickest and densest towards the epithelial struc- ture, and exhibited a disposition to form about the free surface. The cells were compactly arranged in trabecule as on the skin, and
