ISOPROPYL ACETATE
CH3COOCH(CH3)2
MW: 102.14
METHOD: 1454, Issue 1
CAS: 108-21-4
EVALUATION:
OSHA : 250 ppm NIOSH: no REL ACGIH: 250 ppm; STEL 310 ppm (1 ppm = 4.18 mg/m 3 @ NTP)
1454
RTECS: AI4930000
PARTIAL
PROPERTIES:
Issue 1: 15 August 1994
colorless liquid; BP 89.4 °C; d 0.87 g/mL @ 20 °C; miscible in most organic solvents; VP 6.33 kPa (47.5 mm Hg) @ 20 °C
SYNONYMS: methyl isobutyl acetate
SAMPLING SAMPLER:
CHARCOAL TUBE (coconut shell charcoal, 100 mg/50 mg)
FLOW RATE:
0.02 to 0.2 L/min
VOL-MIN: -MAX:
0.1 L @ 250 ppm 9L
SHIPMENT:
routine
MEASUREMENT TECHNIQUE:
GAS CHROMATOGRAPHY, FID
ANALYTE:
isopropyl acetate
DESORPTION:
carbon disulfide, 1 mL
INJECTION VOLUME:
5 µL
SAMPLE STABILITY:
not documented
TEMPERATURE-INJECTION: -DETECTOR: -COLUMN:
225 °C 250 °C 60 °C - isothermal
BLANKS:
2 to 10 field blanks per set
CARRIER GAS:
helium, 30 mL/min
COLUMN:
10 ft x 1/8-inch stainless steel, packed with 5% FFAP on 100/120 mesh Supelcoport [1]
CALIBRATION:
standard solutions of isopropyl acetate in carbon disulfide
RANGE:
0.05 to 15 mg per sample [1]
ACCURACY RANGE STUDIED:
446 to 1870 mg/m 3 [1] (8-L samples)
BIAS:
1.1%
ˆ ): 0.067 [1] OVERALL PRECISION (S rT ACCURACY:
±29.4%
ESTIMATED LOD: 0.01 mg per sample [1] PRECISION (Sr):
0.007 @ 3.6 to 15 mg per sample [1]
APPLICABILITY: The working range is 1.5 to 450 ppm (6 to 1870 mg/m 3) for an 8-L air sample.
INTERFERENCES: None identified.
OTHER METHODS: This is NIOSH Method S50 in a revised format [1]. Operational modifications [2] to this method are as follows: column - 30 m x 0.3-mm I.D. fused silica WCOT capillary coated with 1.0-µm DB-1. Column temperature - 45 °C for 16 min, and programmed at 16 °C/min to 150 °C and held for 8 min. Carrier gas - He, with split ratio of 1:10. Desorption - 1 h or more in 1 mL carbon disulfide with 1 µL/mL p-cymene as internal standard.
NIOSH Manual of Analytical Methods (NMAM), Fourth Edition, 8/15/94
