CHLOROACETIC ACID
ClCH2COOH
MW: 94.50
METHOD: 2008, Issue 2
CAS: 79-11-8
2008
RTECS: AF8575000
EVALUATION: FULL
OSHA : no PEL NIOSH: no REL ACGIH: no TLV (1 ppm = 3.87 mg/m 3 @ NTP)
PROPERTIES:
Issue 1: 15 May 1989 Issue 2: 15 August 1994
solid; MP 61 to 63 °C; BP 189 °C; VP 0.1 kPa (0.75 mm Hg) @ 20 °C; flash point 126 °C; lower explosive limit in air 8% v/v
SYNONYMS: chloroethanoic acid; monochloroacetic acid
SAMPLING
MEASUREMENT
SAMPLER:
SOLID SORBENT TUBE (silica gel, 100 mg/50 mg)
TECHNIQUE:
ION CHROMATOGRAPHY, CONDUCTIVITY DETECTION
FLOW RATE:
0.05 to 0.2 L/min
ANALYTE:
chloroacetate ion
VOL-MIN: -MAX:
1 L @ 0.25 ppm 100 L
DESORPTION:
2 mL deionized water
SHIPMENT:
routine
INJECTION LOOP VOLUME:
500 µL
ELUENT:
1.5 mM NaHCO 3; 1.0 mL/min
COLUMNS:
Ion Pac AS4A Separator, AG4A Guard, micromembrane suppressor (see OTHER METHODS)
CALIBRATION:
standard solutions of chloroacetic acid in deionized water
RANGE:
1 to 80 µg per sample [1]
SAMPLE STABILITY:
BLANKS:
at least 7 days @ 25 °C; 32 days refrigerated [1] 2 to 10 field blanks per set
ACCURACY RANGE STUDIED:
BIAS:
0.35 to 29 mg/m 3 [1,2] (3-L samples)
ESTIMATED LOD: 0.04 µg per sample [2]
- 2.0%
PRECISION (Sr):
0.016 [1]
ˆ ): 0.08 [1] OVERALL PRECISION (S rT ACCURACY:
± 17.7%
APPLICABILITY: The working range is 0.09 to >85 ppm (0.3 to 30 mg/m 3) for a 3-L air sample.
INTERFERENCES: Chloroacetyl chloride is a positive interferent since it is hydrolyzed to monochloroacetic acid by the measurement procedure and is efficiently collected by silica gel [3]. Particulate salts of the acid are positive interfe rents. The chromatographic conditions given will separate acetate, chloride, dichloroacetate, fluoride, glycolate, and trichloroace tate ions from chloroacetate ion.
OTHER METHODS: This revises P&CAM 332 [2]. The columns used in P&CAM 332 are no longer available. The newer columns indicated here show improvements in the analytical range and sensitivity.
NIOSH Manual of Analytical Methods (NMAM), Fourth Edition, 8/15/94
