ACETONE CYANOHYDRIN 2506 (CH3)2C(OH)CN MW: 85.11 CAS: 75-86-5 RTECS: OD9275000 METHOD: 2506, Issue 2
EVALUATION: PARTIAL
OSHA: no PEL NIOSH: C 1 ppm/15 min ACGIH: no TLV
(1 ppm = 3.48 mg/m³
Issue 1: 15 May 1985 Issue 2: 15 August 1994
PROPERTIES: liquid; d 0.932 g/mL @ 19 °C; BP 95 °C; MP −19 °C; VP 110 Pa (0.8 mm Hg) @ 20 °C
SYNONYMS: 2-cyano-2-propanol; 2-methyllactonitrile; 2-hydroxy-2-methylpropanenitrile SAMPLING
MEASUREMENT
SAMPLER: SOLID SORBENT TUBE (Porapak QS, 100 mg/50 mg)
TECHNIQUE:
GAS CHROMATOGRAPH, NP (THERMIONIC) DETECTOR
FLOW RATE: 0.2 L/min
ANALYTE:
acetone cyanohydrin
VOL-MIN: -MAX:
DESORPTION:
1 mL ethyl acetate; ultrasonicate 60 min
SHIPMENT: in refrigerated container @ 0 °C
INJECTION VOLUME:
5 µL, 1 µL flush
SAMPLE STABILITY: at least 5 days if stored at @ 0 °C immediately following collection
TEMPERATURE-INJECTION: 100 °C -DETECTOR: 100 °C -COLUMN: 70 °C
BLANKS:
CARRIER GAS:
N2, 33 mL/min
COLUMN:
PTFE, 2 m × 3.2-mm OD, packed with 5% OV-17 on 40/60 mesh Chromosorb T (APPENDIX)
CALIBRATION:
solutions of acetone cyanohydrin in ethyl acetate
OVERALL PRECISION ( ): 0.093 [1]
RANGE:
1 to 50 µg per sample
ACCURACY:
ESTIMATED LOD: 0.1 µg per sample [1]
0.3 L @ 1 ppm 12 L
2 to 10 field blanks per set ACCURACY
RANGE STUDIED:
0.33 to 16.7 mg/m³ [1] (3-L samples)
BIAS:
not determined
not determined
PRECISION ( ):
0.042 [1]
APPLICABILITY: The working range is 0.1 to 4.8 ppm (0.33 to 17 mg/m³) for a 3-L air sample. However, coadsorbed water vapor will decompose the analyte unless the samples are refrigerated immediately after collection. INTERFERENCES: Acetone, methyl methacrylate and methanol do not interfere with the analysis. Methacrylamide does not elute from the column under the conditions given above. The gas chromatograph must be modified to eliminate contact of analyte with heated glass or metal surfaces. OTHER METHODS: This method was originally designated P&CAM 340 [2].
NIOSH Manual of Analytical Methods (NMAM), Fourth Edition
