DIAZOMETHANE CH2=N+N-
MW: 42.04
METHOD: 2515, Issue 2
2515
CAS: 334-88-3
RTECS: PA7000000
EVALUATION: PARTIAL
OSHA : 0.2 ppm NIOSH: 0.2 ppm ACGIH: 0.2 ppm; suspect carcinogen (1 ppm = 1.719 mg/m 3 @ NTP)
Issue 1: 15 May 1985 Issue 2: 15 August 1994
PROPERTIES: yellow gas; MP -145 °C; BP -23 °C; pure material explodes above 150 °C; impure material explodes at lower temp.
SYNONYMS: azimethylene; diazirine
SAMPLING SAMPLER:
MEASUREMENT
SOLID SORBENT TUBE (octanoic acid-coated XAD-2 resin, 100 mg/50 mg)
TECHNIQUE:
GAS CHROMATOGRAPHY, FID
ANALYTE:
methyl octanoate
FLOW RATE:
0.2 L/min
DESORPTION:
1 mL carbon disulfide; stand 30 min
VOL-MIN: -MAX:
6L 30 L
INJECTION VOLUME:
SHIPMENT:
routine
TEMPERATURE-INJECTION: -DETECTOR: -COLUMN:
SAMPLE STABILITY:
not determined
CARRIER GAS:
N 2, 30 mL/min
BLANKS:
2 to 10 field blanks per set
COLUMN:
stainless steel, 3 m x 3-mm OD, 5% SP-1000 on 100/120 mesh Chromosorb WHP preceded by a 15 cm x 3-mm OD stainless steel precolumn packed with 10% Carbowax 20M and 1.2% NaOH on 80/100 mesh Gas Chrom Q
CALIBRATION:
methyl octanoate in carbon disulfide with internal standard
RANGE:
2 to 8 µg diazomethane (8 to 32 µg methyl octanoate) per sample
ACCURACY RANGE STUDIED:
BIAS:
0.17 to 0.80 mg/m 3 [1] (10-L samples) -30% at 0.17 mg/m 3 [1]; -10% at 0.36 to 0.75 mg/m 3 [1]
ˆ ): 0.084 [1] OVERALL PRECISION (S rT ACCURACY:
22.5% at 0.36 to 0.75 mg/m 3
5 µL 225 °C 250 °C 95 °C
ESTIMATED LOD: not determined PRECISION (Sr):
0.024 [1]
APPLICABILITY: The working range is 0.1 to 0.6 ppm (0.2 to 1 mg/m 3) diazomethane for a 10-L air sample.
INTERFERENCES: None reported.
OTHER METHODS: This revises S137 [2].
NIOSH Manual of Analytical Methods (NMAM), Fourth Edition, 8/15/94
