GLUTARALDEHYDE
O=CH(CH2)3CH=O
MW: 100.12
METHOD: 2532, Issue 1
OSHA : NIOSH: ACGIH:
2532
CAS: 111-30-8
RTECS: MA2450000
EVALUATION: PARTIAL
no PEL C 0.2 ppm C 0.2 ppm (1 ppm = 4.09 mg/m3 @ NTP)
PROPERTIES:
Issue 1: 15 August 1994
oil; d 0.72 g/mL @ 20 C; BP 188 C; MP 14 C; VP 2.2 kPa (17 mm Hg) @ 20 C
SYNONYMS: glutaric dialdehyde; 1,5-pentanedial; glutaral; 1,3-diformylpropane
SAMPLING SAMPLER:
MEASUREMENT
SOLID SORBENT TUBE (silica gel coated with 2,4-dinitrophenylhydrazine HCl, 300 mg/150 mg)
TECHNIQUE:
HPLC, UV DETECTION
ANALYTE:
glutaraldehyde dinitrophenylhydrazone
FLOW RATE: 0.05 to 0.5 L/min
EXTRACTION:
3 mL acetonitrile; shaken 2 h
VOL-MIN: 1 L @ 0.2 ppm -MAX: 30 L
INJECTION VOLUME:
25 µL
SHIPMENT:
routine
MOBILE PHASE:
65% acetonitrile/35% water
SAMPLE STABILITY:
FLOWRATE:
1.5 mL/min
at least 30 days @ 25 C COLUMN:
reverse phase C8, 5- m particle size (Alltech Altima C8, 5- m or equivalent)
DETECTOR:
UV at 365 nm
CALIBRATION:
standard solutions spiked onto sampler tubes
RANGE:
0.8 to 24 µg per sample
BLANKS:
2 to 10 field blanks per set; 10 to 20 media blanks per set
ACCURACY RANGE STUDIED:
none
ACCURACY:
not determined
BIAS:
not determined
OVERALL PRECISION (
rT):
not determined
ESTIMATED LOD: 0.3 µg per sample PRECISION ( r):
0.007 @ 12 µg per sample; 0.025 @ 1.2 µg per sample
APPLICABILITY: The working range is 0.01 to 0.3 ppm (0.04 to 1.2 mg/m3) for a 20-L air sample.
INTERFERENCES: Other aldehydes and ketones react with 2,4-dinitrophenylhydrazine but can be resolved using proper HPLC parameters.
OTHER METHODS: OSHA Method 64 [1] uses a glass fiber filter coated with 2,4-dinitrophenylhydrazine and phosphoric acid for collection, with HPLC analysis.
NIOSH Manual of Analytical Methods (NMAM), Fourth Edition
