MANEB Hand Wash C4H6N2S4Mn
MW:
265.2
METHOD: 3601, Issue 1
CAS: 124-38-2
3601
RTECS: OP07000
EVALUATION: PARTIAL
OSHA : not applicable NIOSH: not applicable ACGIH: not applicable
PROPERTIES:
Issue 1: 15 March 2003
powder, yellow, wettable; sparingly soluble in water and organic solvents; vp not significant
NAMES & SYNONYMS: manganous ethylenebis(dithiocarbamic acid), Manzate; Dithane M-22
SAMPLING
MEASUREMENT
SAMPLER:
PLASTIC BAG containing hand-wash solution,150 mL
SHIPMENT:
add 1 g L-cysteine, 3 g Na4 EDTACH2 O to each sample, ship in refrigerant packs, 4 °C, via overnight express
SAMPLE STABILITY:
at least 1 week at 4 °C
BLANKS:
2 to 10 field blanks per set
ACCURACY RANGE STUDIED: BIAS:
not determined not determined
OVERALL PRECISION ( Ö r T ): not determined ACCURACY:
TECHNIQUE:
HPLC, UV detection
ANALYTE:
ethylenebisdithiocarbamate anion
INJECTION VOLUME:
100 µL
MOBILE PHASE: 0.0675 M phosphate, 0.0525 M NaClO4 , pH 6.9, 1 g/L Na2 EDTA C2H2 O, 2 mL/min COLUMN:
Dionex AS7 anion exchange column, GS7 guard column or equivalent
DETECTOR:
UV, 285 nm (8 max) or 254 nm
CALIBRATION:
solutions of Maneb in 1% L-cysteine, 3% Na2 EDTA
RANGE:
0.03 to 15 mg/sample [1]
ESTIMATED LOD: 0.2 µg/mL or 0.03 mg/sample [1] PRECISION ( þ r ):
0.015 [1]
not determined
APPLICABILITY: This method determines Maneb washed from the hands of workers. It is applicable to the determination of Zineb, Mancozeb, and Nabam since these all convert to the same analyte when dissolved in EDTA solution.
INTERFERENCES: Not thoroughly investigated. No interferences have been found during method development.
OTHER METHODS: Maneb can also be determined by first methylating followed by HPLC analysis with a C18 column [2-5].
NIOSH Manual of Analytical Methods, Fourth Edition
