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ACETONE and METHYL ETHYL KETONE in urine: METHOD 8319, Issue 1, dated 28 October 2014 - Page 5 of 6

[5] Downs CC, Perkins JB [2002]. Back-up data report for acetone and methyl ethyl ketone method development. DataChem Laboratories, Inc. under NIOSH contracts CDC-200-95-2955 and CDC-200-2001-08000. [6] Pezzagno G, Imbriani M, Ghittori S, Capodaglio E, Huang J [1986]. Urinary elimination of acetone in experimental and occupational exposure. Scand J Work Environ Health 12:603-608. [7] Perbellini L, Brugnone F, Mozzo P, Cocheo V, Caretta D [1984]. Methyl ethyl ketone exposure in industrial workers. Uptake and kinetics. Int Arch Occup Environ Health 54:73-81. [8] Kawai T, Yasugi T, Horiguchi S, Uchida Y, Iwami O, Iguchi H, Inoue O, Watanabe T, Nakatsuka H, Ikeda M [1990]. Biological monitoring of occupational exposure to isopropyl alcohol vapor by urinalysis for acetone. Int Arch Occup Environ Health 62:409-413. [9] Williams RT [1950]. Detoxication mechanisms: the metabolism and detoxication of drugs, toxic substances and other organic compounds. Chapman & Hall Ltd., London p. 66. [10] Bales JR, Bell JD, Nicholson JK, Sadler PJ [1986]. HNMR Studies of urine during fasting: excretion of ketone bodies and acetylcamitine. Magn Reson Med 3:849-856. [11] Liira J, Riihimaki V, Engstrom K [1990]. Effects of ethanol on the kinetics of inhaled methyl ethyl ketone in man. Br J Ind Med 47:325-330. [12] Tomicic C, Berode M, Oppliger A, Castella V, Leyvraz F, Praz-Christinaz S-M, Danuser B [2011]. Sex differences in urinary levels of several biological indicators of exposure: A human volunteer study. Toxicol Lett 202:218-225. [13] Angerer J, Gündel J [2012]. Alcohols and Ketones [Biomonitoring Methods, 1996]. The MAK Collection for Occupational Health and Safety. pp. 1-33. [14] ASTM [2011]. ASTM Standard D1193, Standard specification for reagent water. ASTM International, West Conshohocken, PA. DOI 10.1520/D1193-06R11. [15] CDC [2007]. 2007 Guidelines for isolation precautions: Preventing transmission of infectious agents in healthcare settings. http://www.cdc.gov/hicpac/2007IP/2007isolationprecautions.html. [Date accessed: April 2013.] [16] Burkart JA [1986]. General procedures for limit of detection calculations in the industrial hygiene chemistry laboratory. Appl Ind Hyg 1(3):153-155. METHOD WRITTEN BY: Corey C. Downs and James B. Perkins, DataChem Laboratories, Inc., Salt Lake City, Utah under NIOSH Contracts CDC-200-95-2955 and CDC-200-2001-08000. Final editing by Dale A. Shoemaker, Ph.D., NIOSH/DART. Disclaimer: Mention of any company or product does not constitute endorsement by the National Institute for Occupational Safety and Health. In addition, citations to Web sites external to NIOSH do not constitute NIOSH endorsement of the sponsoring organizations or their programs or products. Furthermore, NIOSH is not responsible for the content of these Web sites. All Web addresses referenced in this document were accessible at the time of publication.

NIOSH Manual of Analytical Methods (NMAM), Fifth Edition