METHAMPHETAMINE . . . on Wipes by SPE: METHOD 9109, Issue 1, dated 17 October 2011 - Page 10 of 33
Table 1. Formula and registry numbers of analytes MW(1) (Daltons) Compound (alphabetically)
Free base
HCl salt
Hemisulfate salt
Structural Formula As free base
(DL)-Amphetamine
135.21
171.67
184.25
C6H5·CH2·CH(CH3)·NH2
(D)-Amphetamine(7)
135.21
171.67
184.25
C6H5·CH2·CH(CH3)·NH2
(L)-Amphetamine
135.21
171.67
184.25
Caffeine
194.19
(DL)-Ephedrine
165.24
201.70
(L)-Ephedrine(8)
165.24
(D)-Ephedrine
CAS #(2)
RTECS(6) SH9450000 SI1750000 SI1400000
C6H5·CH2·CH(CH3)·NH2
300-62-9 60-13-9(5) 51-64-9(3) 51-63-8(5) 156-34-3(3)
(CH3)3·[C5HN4O2]
58-08-2
EV6475000
214.28
C6H5·CH(OH)·CH(CH3)·NH·CH3
201.70
214.28
C6H5·CH(OH)·CH(CH3)NH·CH3
90-81-3 134-71-4(4) 299-42-3(3) 50-98-6(4) 134-72-5(5)
165.24
201.70
214.28
C6H5·CH(OH)·CH(CH3)NH·CH3
(±)-MDEA
207.27
243.73
CH2O2C6H3·CH2·CH(CH3)NH·C2H5
(±)-MDMA
193.24
229.71
CH2O2C6H3·CH2·CH(CH3)·NH·CH3
(+)-MDMA(7) (DL)-Methamphetamine
193.24 149.24
229.71 185.70
198.28
CH2O2C6H3·CH2·CH(CH3)·NH·CH3 C6H5·CH2·CH(CH3)·NH·CH3
(D)-Methamphetamine(7)
149.24
185.70
198.28
C6H5·CH2·CH(CH3)·NH·CH3
(L)-Methamphetamine
149.24
185.70
198.28
C6H5·CH2·CH(CH3)·NH·CH3
Phencyclidine
243.39
279.85
C6H5·C[C5H10]·N[C5H10]
Phentermine
149.24
185.70
C6H5·CH2·C(CH3)2·NH2
(DL)-Norephedrine
151.21
187.67
200.25
C6H5·CH(OH)·CH(CH3)·NH2
1R,2S (-)-Norephedrine
151.21
187.67
200.25
1S,2R (+)-Norephedrine
151.21
187.67
1S,2S (+)-Norephedrine
151.21
(D)-Pseudoephedrine(8,9) (L)-Pseudoephedrine(10)
(3)
(3)
SH9050000
(3)
321-98-2(3) 24221-86-1(4) 82801-81-8(3) 116261-63-2(4) 42542-10-9(3) 92279-84-0(4) 64057-70-1(4) 4846-07-5(3)
KB0700000 KB1750000 KB2625000 KB0600000 KB1925000
SH5700000 SH5700000
537-46-2(3) 51-57-0(4) 33817-09-3(3)
SH4910000 SH5455000 SH4905000 TN2272600 TN2272600 SH4950000
C6H5·CH(OH)·CH(CH3)·NH2
77-10-1(3) 956-90-1(4) 122-09-8(3) 1197-21-3(4) 14838-15-4(3) 154-41-6(4) 492-41-1(3)
200.25
C6H5·CH(OH)·CH(CH3)·NH2
37577-28-9(3)
187.67
200.25
C6H5·CH(OH)·CH(CH3)·NH2
165.24
201.70
214.28
C6H5·CH(OH)·CH(CH3)·NHCH3
165.24
201.70
214.28
C6H5·CH(OH)·CH(CH3)·NH·CH3
36393-56-3 2153-98-2(4) 492-39-7(4) 90-82-4(3) 345-78-8(4) 321-97-1(3)
RC2625000 DN4200000 RC2275000
RC9275000
UL5800000 UL5950000
(1) Molecular weights are calculated from the empirical formula using the 1987 IUPAC Atomic Weights of the Elements, Merck Index [10]. The molecular weight of the hemisulfate is ½ the weight of the 2:1 sulfate salt (2 moles amine + 1 mole H2SO4). (2) CAS from various sources: Merck Index [13], NIOSH RTECS [14], MSDS sheets from Sigma/Aldrich [15], Cerilliant [16], and other sources [17]. (3) Free base form. (4) Hydrochloride salt. (5) 2:1 Sulfate salt (2 moles amine + 1 mole H2SO4. (6) RTECS = NIOSH Registry of Toxic Effects of Chemical Substances [14]. (7) More active isomer. (8) Naturally occurring isomer. (9) The D form of pseudoephedrine is a decongestant. (10) The L form of pseudoephedrine is a bronchodilator. Dehydroxylation forms the less active L-methamphetamine.
Method rev. 1.1.1
NIOSH Manual of Analytical Methods (NMAM), Fifth Edition
