METHAMPHETAMINE . . . on Wipes by SPE: METHOD 9109, Issue 1, dated 17 October 2011 - Page 17 of 33
Table 8a. Precision and accuracy in scan mode for cotton gauze(1) Bias
Overall
Compound
Internal Standard(2)
Range(3) µg/sample
Accuracy
Precision
(D)-Amphetamine
D11-Amp
0.1-30
8.1
0.0412
-0.0054
-0.0386 to +0.0428
D14-Met
0.1-30
10.3
0.0472
-0.0227
-0.0844 to +0.0199
NMPhen
0.1-30
13.2
0.0662
-0.0120
-0.0931 to +0.0290
D11-Amp
1.0-30
15.8
0.0469
+0.0810
+0.0416 to +0.1375
D14-Met
3-30
13.3
0.0422
+0.0631
+0.0003 to +0.1294
NMPhen
0.3-30
20.2
0.0729
+0.0823
-0.0092 to +0.1359
D11-Amp
0.1-30
9.8
0.0499
-0.0052
-0.0608 to +0.0262
D14-Met
0.1-30
9.2
0.0397
-0.0266
-0.0463 to +0.0221
NMPhen
0.1-30
11.2
0.0493
-0.0284
-0.0775 to +0.0302
MDEA
N-PAmp
0.3-29
12.4
0.0618
+0.0127
-0.0475 to +0.0869
MDMA
D11-Amp
0.1-27
14.3
0.0568
+0.0497
+0.0104 to +0.1197
D14-Met
0.1-27
13.1
0.0558
+0.0389
-0.0189 to +0.0978
NMPhen
0.3-27
11.9
0.0605
+0.0007
-0.0570 to +0.0360
D11-Amp
0.1-10
9.2
0.0395
+0.0270
-0.0289 to +0.0923
D14-Met
0.1-30
5.9
0.0302
+0.0015
-0.0440 to +0.0592
NMPhen
0.3-30
6.9
0.0334
+0.0113
-0.0534 to +0.0448
D11-Amp
0.3-30
17.2
0.0639
+0.0670
+0.0059 to +0.1222
D14-Met
0.3-30
15.9
0.0648
+0.0521
-0.0386 to +0.1039
NMPhen
0.3-30
16.0
0.0638
+0.0547
-0.0474 to +0.0886
D11-Amp
0.1-30
10.1
0.0444
+0.0261
-0.0067 to +0.0912
D14-Met
0.1-30
10.4
0.0527
+0.0041
-0.0600 to +0.0674
NMPhen
1.0-30
8.2
0.0400
+0.0121
-0.0378 to +0.0407
D11-Amp
0.1-30
12.2
0.0571
+0.0241
+0.0500 to +0.0610
D14-Met
0.1-30
12.5
0.0638
-0.0005
-0.0674 to +0.0708
NMPhen
0.1-30
13.3
0.0675
+0.0036
-0.0533 to +0.0476
D11-Amp
0.1-30
10.0
0.0507
-0.0059
-0.0530 to +0.0441
D14-Met
0.1-30
12.3
0.0507
-0.0392
-0.0737 to +0.0301
NMPhen
1.0-30
15.6
0.0716
-0.0350
-0.0813 to +0.0617
Cocaine
(L)-Ephedrine
(D)-Methamphetamine
Phencyclidine
Phentermine
(±)-Norephedrine(4)
Pseudoephedrine
Average
Range
(1) Backup Data Report [2]. Values are for the heptafluorobutyryl and mixed heptafluorobutyryl-trimethylsilyl derivatives and analysis by GC-MS in scan mode. Each sample consisted of a pair of 3” x 3” 12-ply cotton gauze pads. There were 6 replicate samples per concentration level and six concentration levels evaluated from approximately 0.1 to 30 µg/sample. (2) Internal Standards Deuterated:
Non-deuterated:
D11-Amp = Amphetamine-D11 NMPhen = N-Methyl phenethylamine D14-Met = Methamphetamine-D14 N-PAmp = N-Propyl amphetamine (3) Range used for calculation of precision, accuracy, and bias. The entire range studied for all analytes was approximately 0.1 to 30 µg/sample (1xLOQ to 300xLOQ). (4) (±)-Norephedrine = (±)-phenylpropanolamine.
NIOSH Manual of Analytical Methods (NMAM), Fifth Edition
Method rev. 1.1.1
