METHAMPHETAMINE . . . on Wipes by SPE: METHOD 9109, Issue 1, dated 17 October 2011 - Page 19 of 33
Table 9b. Recommended best application of internal standards(1) Recommended Alternate Non-deuterated Internal Standards(3)
Recommended Deuterated Internal Standards Target Analyte
Amphetamine-D11(2)
Methamphetamine-D14(2)
Amphetamine
X
X
X
Cocaine
X
X
X
Ephedrine
X
X
X
MDEA
MDEA-D6(1) Phencyclidine-D5
N-Methylphenethylamine
X
X
MDMA
X
X
X
Methamphetamine
X
X
X
Phencyclidine
X
X
Phentermine
X
X
X
(±)-Norephedrine
X
X
X
Pseudoephedrine
X
X
X
(4)
N-Propylamphetamine(1)
X
X
(1) N-Propylamphetamine and MDEA-D6 are only applicable to MDEA and other hindered amines (e.g., fenfluramine and MBDB) due to similar steric hindrance at the nitrogen (N-ethyl or N-propyl substitution) which affects derivatization efficiency. (2) The alternate deuterated compounds listed in part A above may be used. Avoid ring-labeled amphetamine-D5 (CAS 65538-33-2) since the primary (quantification) ion is the same as for amphetamine and GC peaks overlap significantly. Also avoid methamphetamine-D5 (CAS 60124-88-1) since GC peaks significantly overlap. (3) The listed non-deuterated compounds are acceptable as internal standards for the listed target analytes for the applicable ranges and limits of detection listed in Tables 8a and 8b respectively. Non-deuterated internal standards might not be permissible. Consult regulations of agency having legal jurisdiction. (4) (±)-Norephedrine is the same as (±)-phenylpropanolamine.
NIOSH Manual of Analytical Methods (NMAM), Fifth Edition
Method rev. 1.1.1
