cesses, the axon of the nerve cell, is continued into the axial cylinder of a nerve fiber, and that in the multipolar nerve cell the other processes, or dendrites, branch and ramify for some distance away from the body. A nerve fiber is, therefore, an essential part of the cell with which it is continuous, and the cell, its processes, the nerve fiber and the collaterals which arise from the nerve fiber collectively form a neuron or structural nerve unit (Waldeyer). The nucleated body of the nerve cell is the physiological center of the unit.
The cell plasm occupies both the body of the nerve cell and its processes. The intimate structure of the plasm has, by improved methods of observation introduced during the last eight years by Nissl, and conducted on similar lines by other investigators, become more definitely understood. It has been ascertained that it possesses two distinct characters which imply different structures. One of these stains deeply on the addition of certain dyes, and is named chromophile or chromatic substance; the other, which does not possess a similar property, is the achromatic network. The chromophile is found in the cell body and the dendritic processes, but not in the axon. It occurs in the form of granular particles, which may be scattered throughout the plasm, or aggregated into little heaps which are elongated or fusiform in shape and appear as distinct colored particles or masses. The achromatic network is found in the cell body and the dendrites, and is continued also in the axon, where it forms the axial cylinder of the nerve fiber. It consists apparently of delicate threads or fibrillæ, in the meshes of which a homogeneous material, such as is found in cell plasm generally, is contained. In the nerve cells, as in other cells, the plasm is without doubt concerned in the process of cell nutrition. The achromatic fibrillæ exercise an important influence on the axon or nerve fiber with which they are continuous, and probably they conduct the nerve impulses which manifest themselves in the form of nerve energy. The dendritic processes of a multipolar nerve cell ramify in close relation with similar processes branching from other cells in the same group. The collaterals and the free end of the axon fiber process branch and ramify in association with the body of a nerve cell or of its dendrites. We cannot say that these parts are directly continuous with each other to form an intercellular network, but they are apparently in apposition, and through contact exercise influence one on the other in the transmission of nerve impulses.
There is evidence to show that in the nerve cell the nucleus, as well as the cell plasm, is an effective agent in nutrition. When the cell is functionally active, both the cell body and the nucleus increase in size (Vas, G. Mann, Lugaro); on the other hand, when nerve cells are fatigued through excessive use, the nucleus decreases in size and shrivels; the cell plasm also shrinks, and its colored or chromophile con-
