presents the subject rather inadequately, but it will serve to show what I mean. Further, the composition of the various juices is admirably adjusted to the needs of the organism; when there is much proteid to be digested, the proteolytic activity of the juices secreted is correspondingly high, and the same is true for the other constituents of the food. It is such general conclusions as these, the correlation of isolated facts leading to the formulation of the law that the digestive process is continuous in the sense I have indicated and adapted to the needs of the work to be done, that constitute the great value of the work from the Russian laboratory. Work of this sort is sure to stimulate others to fill in the gaps and complete the picture, and already has borne fruit in this direction. It has, for instance, in Starling's hands led to the discovery of a chemical stimulus to pancreatic secretion. This is formed in the intestine as the result of the action of the gastric acid, and taken by the blood-stream to the pancreas. Whether this secretin as it is called may be one of a group of similar chemical stimuli which operate in other parts of the body has still to be found out.
The other series of researches to which I referred are those of Ehrlich and his colleagues and followers on the subject of immunity. This subject is one of such importance to every one of us that I am inclined to place the discovery on a level with those great discoveries of natural laws to which I alluded at the outset of this portion of my address. I hesitate to do so yet because many of the details of the theory still await verification. But up to the present all is working in that direction, and Ehrlich 's ideas illustrate the value of bold theorizing in the hands of clear-sighted and far-seeing individuals.
But when I say that the doctrine is bold, I do not mean to infer that the experimental facts are scanty; they are just the reverse. But in the same way that a chemist has never seen an atom, and yet he believes atoms exist, so no one has yet ever seen a toxin or antitoxin in a state of purity, and yet we know they exist, and this knowledge promises to be of incalculable benefit to suffering humanity.
It may not be uninteresting to state briefly, for the benefit of those to whom the subject is new, the main facts and an outline of the theory which is based upon them.
We are all aware that one attack of many infective maladies protects us against another attack of the same disease. The person is said to be immune either partially or completely against that disease. Vaccination produces in a patient an attack of cowpox or vaccinia. This disease is related to smallpox, and some still hold that it is smallpox modified and rendered less malignant by passing through the body of a calf. At any rate an attack of vaccinia renders a person immune to smallpox, or variola, for a certain number of years. Vaccination is an instance of what is called protective inoculation, which is now practised
