influences could bring about a directly responsive organic change, which he assumed was inherited. Lamarck developed the well-known view, previously advocated by Erasmus Darwin, that indirect responses to the environment could be fixed in inheritance as so-called "acquired characters," meaning by this phrase that such characters are acquisitions during the life-time of an individual as the effects of disuse or unusual use, or of new habits. Coming again to Darwin, we find that he endeavored to support Lamarck's doctrine and to supplement his doctrine of selection by adding the theory of pangenesis. According to this every cell of every tissue and organ of the body produces minute particles called gemmules, which partake of the characters of the cells that produce them. The gemmules were supposed to be transported throughout the entire body, and to congregate in the germ-cells, which would be in a sense minute editions of the body which bears them, and would so be capable of producing the same kind of a body. If true, this view would lead to the acceptance of Lamarck's or even Buffon's doctrine, for changes induced in any organ by other than congenital factors could be impressed upon the germ-cell, and would then be transported together with the original specific characters to future generations. Darwin was indeed a good Lamarckian.
But the researches of post-Darwinians, and especially those of the students of cellular phenomena, have demonstrated that such a view has no real basis in fact. Many naturalists, like Naegeli and Wiesner, were convinced that there was a specific substance concerned with hereditary qualities as in a larger way protoplasm is the physical basis of life. It remained for Weismann to identify this theoretical substance with a specific part of the cell, namely, the deeply-staining substance, or chromatin, contained in the nucleus of every cell. Bringing together the accumulating observations of the numerous cytologists of his time, and utilizing them for the development of his somewhat speculative theories, Weismann published in 1882 a volume called "The Germ-Plasm," which is an immortal foundation for the later work on inheritance. The essential principles of the germ-plasm theory are somewhat as follows: The chromatin of the nucleus contains the determinants of hereditary qualities. In reproduction, the male sex-cell, which is scarcely more than a minute mass of chromatin provided with a thin coat of protoplasm and a motile organ, fuses with the egg, and the nuclei of the two cells unite to form a double body, which contains equal contributions of chromatin from the two parental organisms. This gives the physical basis for paternal inheritance as well as for maternal inheritance, and it shows why they may be of the same or equivalent degree. When, now, the egg divides, at the first and later cleavages, the chromatin masses or chromosomes contained in the double nucleus are split lengthwise and the twin portions separate to go into
