that tendency operates alone, or in combination with no agencies but those of which the effect can, from previous knowledge, be calculated and allowed for.
Accordingly, in the cases, unfortunately very numerous and important, in which the causes do not suffer themselves to be separated and observed apart, there is much difficulty in laying down with due certainty the inductive foundation necessary to support the deductive method. This difficulty is most of all conspicuous in the case of physiological phenomena; it being seldom possible to separate the different agencies which collectively compose an organized body, without destroying the very phenomena which it is our object to investigate:
We lose it, in the moment we detect.
And for this reason I am inclined to the opinion that physiology (greatly and rapidly progressive as it now is) is embarrassed by greater natural difficulties, and is probably susceptible of a less degree of ultimate perfection, than even the social science; inasmuch as it is possible to study the laws and operations of one human mind apart from other minds, much less imperfectly than we can study the laws of one organ or tissue of the human body apart from the other organs or tissues.
It has been judiciously remarked that pathological facts, or, to speak in common language, diseases in their different forms and degrees afford in the case of physiological investigation the most valuable equivalent to experimentation properly so called; inasmuch as they often exhibit to us a definite disturbance in some one organ or organic function, the remaining organs and functions being, in the first instance at least, unaffected. It is true that from the perpetual actions and reactions which are going on among all parts of the organic economy, there can be no prolonged disturbance in any one function without ultimately involving many of the others; and when once it has done so, the experiment for the most part loses its scientific value. All depends on observing the early stages of the derangement; which, unfortunately, are of necessity the least marked. If, however, the organs and functions not disturbed in the first instance become affected in a fixed order of succession, some light is thereby thrown upon the action which one organ exercises over another: and we occasionally obtain a series of effects which we can refer with some confidence to the original local derangement; but for this it is necessary that we should know that the original derangement was local. If it was what is termed constitutional; that is, if we do not know in what part of the animal economy it took its rise, or the precise nature of the disturbance which took place in that part, we are unable to determine which of the various derangements was cause and which effect; which of them were produced by one another, and which by the direct, though perhaps tardy, action of the original cause.
Besides natural pathological facts, we can produce pathological facts artificially: we can try experiments, even in the popular sense of the term, by subjecting the living being to some external agent, such as the mercury of our former example, or the section of a nerve to ascertain the functions of different parts of the nervous system. As this experimentation is not intended to obtain a direct solution of any practical question, but to discover general laws, from which afterward the conditions of any particular effect may be obtained by deduction, the best cases to select are those of which the circumstances can be best ascertained: and such are generally
