[18]
children, who sickened at the usual time, and went through all the common stages and symptoms of the small-pox. It would seem from these fads, that it is necessary the small-pox should produce some impression upon the whole system, in order to render it ever afterwards incapable of receiving an impression of a similar nature. A fever and an eruption therefore seem necessary for this purpose. As the inflammation of the arm on the eighth day is a sign of the topical and cuticular infection; so an eruption (though ever so small) seems to be the only certain sign of the infection of the whole system. The eruption is the more decisive in its report in proportion as it comes out and goes off in the usual manner of the small-pox in the natural way. In those cases where patients have been secured against a second attack of the disorder, where there have been no obvious fever or visible eruption, I think I have observed an unusual inflammation, and a copious and long continued discharge of matter from the arm. Perhaps this may serve as an outlet of the matter, which in other cases produces the fever and eruption. I am the more disposed to embrace this opinion from the testimony which several authors have left us of the effects of ulcers in securing the body from the infection of the plague. The effects of issues are still more to our
