opponents at the time when its introduction into the materia medica was made the subject of controversy over Europe, Broussais maintained that it causes chronic inflammation of the stomach or intestines;[1] and Dr. Astbury inferred, from an instance which fell under his notice, that it may bring on dropsy.[2] Neither of these ideas is supported by the general experience of the profession; and although some persons even of late have alleged that those, who take it medicinally to any material amount, invariably die soon after of some chronic disease,[3] there cannot be a doubt, that, under proper restriction, it is both an effectual and a safe remedy.—A case where salivation, with fetor and superficial ulceration of the gums, seemed to have been produced by arsenic, was lately published in an English Journal.[4]
In the present place may also be considered the supposed effects of the celebrated Aqua Toffana or Acquetta di Napoli, a slow poison, which in the sixteenth century, was believed to possess the property of causing death at any determinate period, after months for example, or even years, of ill health, according to the will of the poisoner.
The most authentic description of the aqua Toffana ascribes its properties to arsenic. According to a letter addressed to Hoffman by Garelli, physician to Charles the Sixth of Austria, that Emperor told Garelli, that, being governor of Naples at the time the aqua Toffana was the dread of every noble family in the city, and when the subject was investigated legally, he had an opportunity of examining all the documents,—and that he found the poison was a solution of arsenic in aqua cymbalariæ.[5] The dose was said to be from four to six drops. It was colourless, transparent, and tasteless, like water.
Its alleged effects are thus eloquently described by Behrends, a writer in Uden and Pyl's Magazin. "A certain indescribable change is felt in the whole body, which leads the person to complain to his physician. The physician examines and reflects, but finds no symptom, either external or internal,—no constipation, no vomiting, no inflammation, no fever. In short, he can advise only patience, strict regimen, and laxatives. The malady, however, creeps on; and the physician is again sent for. Still he cannot detect any symptom of note. He infers that there is some stagnation or corruption of the humours, and again advises laxatives. Meanwhile the poison takes firmer hold of the system; languor, wearisomeness and loathing of food continue; the nobler organs gradually become torpid, and the lungs in particular at length begin to suffer. In a word, the malady is from the first incurable; the unhappy victim pines away insensibly, even in the hands of his physician; and thus is he brought to a miserable end through months or years, according to his enemy's desire."[6] An equally vigorous and somewhat clearer account of the
