FURFURYL ALCOHOL: METHOD 2505, Issue 2, dated 15 August 1994 - Page 3 of 4 10. Analyze three quality control blind spikes and three analyst spikes to insure that the calibration graph and DE graph are in control. MEASUREMENT: 11. Set gas chromatograph according to manufacturer's recommendations and to conditions given on page 2505-1. Inject sample aliquot manually using solvent flush technique or with autosampler. NOTE: If peak area is above the linear range of the working standards, dilute with acetone, reanalyze and apply the appropriate dilution factor in calculations. 12. Measure peak area. CALCULATIONS: 13. Determine the mass, mg (corrected for DE) of furfuryl alcohol found in the sample front (W f) and back (W b) sorbent sections, and in the average media blank front (B f) and back (B b) sorbent sections. NOTE: If W b > W f/10, report breakthrough and possible sample loss. 14. Calculate concentration, C, of furfuryl alcohol in the air volume sampled, V (L):
EVALUATION OF METHOD: This method was validated over the range 118 to 478 mg/m 3 on February 18, 1977 using test atmospheres generated dynamically by the vapor pressure saturation/air dilution technique at 765 torr and 22 °C [1,4,6]. At a challenge concentration of 105 ppm (418 mg/m 3), furfuryl alcohol in humidified air (RH>80%) and a flowrate of 0.044 L/min, there was no breakthrough of the front sorbent bed after sampling for 7 hours. The mean desorption efficiency over the range 0.59 to 2.36 mg per sample was 0.96. Recovery of analyte collected (in a 6-L sample) from synthetic atmospheres over the range 118 to 478 mg/m 3 averaged 98.4%. The recovery of the collected analyte (1.2 mg per sample), stored at ambient temperatures for 1 week, was 97%. REFERENCES: [1] Backup Data Report for Furfuryl Alcohol, prepared under NIOSH Contract 210-76-0123, available as "Ten NIOSH Analytical Methods, Set 2," Order No. PB-271-464 from NTIS, Springfield, VA 22161. [2] NIOSH Health Hazard Evaluation Report HHE 80-154-1027, (unpublished, 1981). [3] Holt, J. UBTL Inc., personal communication to NIOSH (1983). [4] NIOSH Manual of Analytical Methods, 2nd. ed., V. 4, S365, U.S. Department of Health, Education, and Welfare, Publ. (NIOSH) 78-175 (1978). [5] NIOSH/OSHA Occupational Health Guidelines for Occupational Hazards, U.S. Department of Health and Human Services, Publ. (NIOSH) 81-123 (1981), available as GPO Stock #017-033-00337-8 from Superintendent of Documents, Washington, DC 20402. [6] NIOSH Research Report - Development and Validation of Methods for Sampling and Analysis of Workplace Toxic Substances, U.S. Department of Health and Human Services, Publ. (NIOSH) 80-133 (1980). METHOD REVISED BY: Robert Glaser, NIOSH/DPSE; S365 originally validated under NIOSH Contract 210-76-0123. APPENDIX:
NIOSH Manual of Analytical Methods (NMAM), Fourth Edition, 8/15/94
