METHYLTIN CHLORIDES: METHOD 5526, Issue 1, dated 15 March 2003 - Page 4 of 5 EVALUATION OF METHOD: This method, developed to collect air samples and analyze the methyltin chlorides, was adapted from existing methodology for measuring organotin compounds in air [3,4]. Reference 1 details the validation of this method for sampling and quantifying of trimethyltin chloride, dimethyltin dichloride and methyltin trichloride in air. The validated method was needed to provide air monitoring capabilities during methyltin chloride and stabilizer production. Table 2 lists the results of the validation experiments which followed the guidelines established by NIOSH [2]. However, fewer replicates and concentration levels were used than recomm ended. This method m et the NIOSH criteria for accuracy, bias and sample stability. The recom m ended sampling conditions are 250 ml/min for 5.5 hours maximum for time-weighted average (TW A) sampling and 1000 ml/min for 20 minutes maximum for short-term exposure limit (STEL) sampling.
REFERENCES: [1] Yoder RE [2000]. Validation of a Method for the Collection and Quantification of M eth yltin C hlorides in the Air. Philadelphia, PA: Atofina Chem icals. Unpublished. [2] NIOSH [1995]. Guidelines for Air Sampling and Analytical Method Development. Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 95-117. [3] NIOSH [1994]. Organotin Co m pounds (as Sn): M eth od 5504. In: Eller PM, Cassinelli ME, eds. NIOSH Manual of Analytical Methods, 4th Ed. Cincinnati, OH: U.S. Department of Health and Human Se rvic es,Pu blic He alth Servic e, C enters for Dis ease Co ntrol and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 94-113. [4] Shangwei H [1997]. Development of a Method for the Sampling and Analysis of Dimethyltin Dichloride and Trimethyltin Chloride [Dissertation]. New Orleans, LA: Tulane University, Department of Environmental Sciences, School of Public Health and Tropical Medicine.
METHOD WRITTEN BY: R.E. Yoder, C. Boraiko, Atofina Chemicals; P.F. O’Connor, NIOSH/DART. TABLE 1. GENERAL INFORMATION Analyte
OSHA PELa (mg/m3)
NIOSH RELb (mg/m3)
ACGIH TLVc (mg/m3)
WH858550 Colorless Crystals MP 48-51°C BP 171°C
0.1
0.1
0.1 0.2 STEL (skin)
753-73-1
WH7245000 Colorless Crystals MP 103-105°C BP 188-190°C
0.1
0.1
0.1 0.2 STEL (skin)
1066-45-1
WH685000 Colorless Crystals MP 37-39°C BP154 °C
0.1
0.1
0.1 0.2 STEL (skin)
Formula
Mol. Wt.
CAS#
Methyltin trichloride
CH3Cl3Sn
240.04
993-16-8
Dimethyltin dichloride
C2H6Cl2Sn
219.67
Trimethyltin chloride
C3H9ClSn
199.25
RTECS#
Properties
a
- OSH A PEL is mea sured as the am ount of Tin (Sn) for orga notin com pounds in air. - NIO SH RE L is m eas ured as the am oun t of T in (Sn ) for organ otin co m pou nds in air. c - AC GIH TL V is m eas ured as the am oun t of T in (Sn ) for organ otin co m pou nds in air.
b
NIOSH Manual of Analytical Methods (NMAM), Fourth Edition
