METHAMPHETAMINE . . . on Wipes by SPE: METHOD 9109, Issue 1, dated 17 October 2011 - Page 22 of 33
TABLE 11. Gas chromatographic retention times for heptafluorobutyryl and trimethylsilyl derivatives of selected drugs of abuse, precursors, and potential adulterants(1) GC Peak No. Compound
Derivative Form(2)
Notes(3)
Retention Time Minutes(4)
Relative Retention Time (5)
Ions (Significant m/z)(7) 1’
(6)
2’(7)
3’(7)
1
Acetaminophen(8)
N,N’- bis-TMS-
Pri.deriv.
12.30
0.9594
1.2374
206
280 [90]
295 [70]
2
Acetaminophen
N-HFB-N’-TMS-
Minor peak
10.37
0.8089
1.0433
330
404 [80]
419 [30]
3
Aminorex
N,N’- bis-HFB-
Major peak
14.12
1.1014
1.4205
385
342 [30]
169 [40]
4
Aminorex
N-HFB-N’-TMS-
Major peak
16.59
1.2941
1.6690
261
146 [48]
128 [45]
5
Amphetamine
N-HFB-
Pri.deriv.
8.54
0.6661
0.8592
240
118 [70]
169 [20]
6
Amphetamine
N-HFB-N-TMS-
OS artifact
9.21
0.7184
0.9266
312
91 [50]
313 [10]
7
(9)
Amphetamine-D5, ring labeled (I$)
N-HFB-
Pri.deriv.
8.47
0.6607
0.8521
240
123 [85]
96 [55]
8
(9)
Amphetamine-D5,ring labeled (I$)
N-HFB-N-TMS-
OS artifact
9.17
0.7153
0.9225
312
96 [45]
73 [95]
9
Amphetamine-D6 (I$)(9)
N-HFB-
Pri.deriv.
8.45
0.6591
0.8501
244
123 [70]
93 [45]
10
Amphetamine-D6 (I$)
N-HFB-N-TMS-
OS artifact
9.14
0.7129
0.9195
316
93 [40]
73 [75]
11
Amphetamine-D8 (I$)
N-HFB-
Pri.deriv.
8.46
0.6599
0.8511
243
126 [75]
96 [40]
12
Amphetamine-D8 (I$)(9)
N-HFB-N-TMS-
OS artifact
9.16
0.7145
0.9215
315
96 [25]
73 [55]
13
Amphetamine-D11 (I$)
N-HFB-
Pri.deriv.
8.46
0.6599
0.8511
244
128 [70]
98 [45]
14
Amphetamine-D11 (I$)
N-HFB-N-TMS-
OS artifact
9.14
0.7129
0.9195
316
98 [60]
73 [70]
15
Atropine(8)
O-TMS-
Pri.deriv.
18.86
1.4711
1.8974
124
361 [9]
82 [17]
16
BDB
N-HFB-
Pri.deriv.
13.35
1.0413
1.3431
135
176 [50]
254 [12]
17
BDB
N-HFB-N-TMS-
OS artifact
13.65
1.0647
1.3732
326
135 [60]
73 [90]
18
Benzoyl ecgonine
O-TMS-
19.18
1.4961
1.9296
82
240 [45]
361 [25]
19
Benzyl piperazine(10) (“Legal XTC”)
N-HFB-
Pri.deriv.
13.73
1.0710
1.3813
91
372 [30]
281 [30]
20
4-Bromo-2,5-DMPEA (Nexus)
N-HFB-
Pri.deriv.
15.79
1.2317
1.5885
242
244 [98]
229 [75]
21
4-Bromo-2,5-DMPEA (Nexus)
N-HFB-N-TMS-
OS artifact
16.22
1.2652
1.6318
229
231 [98]
298 [85]
22
Bupropion (Wellbutrin®, Zyban®)
parent
12.15
0.9477
1.2223
44
100 [45]
111 [20]
23
Caffeine
parent
14.89
1.1615
1.4980
194
109 [45]
67 [45]
24
S-(-)-Cathinone (from Khat plant)
N-HFB-
Pri.deriv.
10.21
0.7964
1.0272
105
77 [45]
240 [15]
25
S-(-)-Cathinone (from Khat plant)
N-HFB-N-TMS-
OS artifact
10.89
0.8495
1.0956
105
312 [68]
77 [55]
26
Chlorpheniramine
parent
16.74
1.3058
1.6841
203
205 [32]
167 [22]
27
Cocaine
parent
18.65
1.4548
1.8763
82
182 [90]
303 [20]
28
Codeine
O-HFB-
Minor peak
19.59
1.5281
1.9708
282
283 [20]
29
Codeine
O-TMS-
Pri.deriv.
20.72
1.6162
2.0845
371
343 [25]
234 [55]
30
Dextromethorphan
parent
18.10
1.4119
1.8209
271
270 [62]
214 [40]
31
Diazepam (Valium® etc.)
parent
20.80
1.6225
2.0926
256
283 [90]
284 [75]
32
Dibromooctafluorobiphenyl (I$)(9)
parent
12.82
1.0000
1.2897
296
456 [100]
454 [50]
33
N,N-Dimethyltryptamine (DMT)
N-HFB-
Pri.deriv.
13.00
1.0140
1.3078
58
129 [15]
42 [15]
34
N,N-Dimethyltryptamine (DMT)
N-TMS-
Minor peak
15.02
1.1716
1.5111
58
73 [12]
202 [10]
35
Ecgonine, methyl ester
O-TMS-
11.72
0.9142
1.1791
82
96 [75]
83 [75]
36
Ephedrine
37 38
(8)
(9) (9)
(9) (9)
(11) (11)
(8)
(8)
(8)
N-HFB-O-TMS-
Pri.deriv.
11.40
0.8892
1.1469
179
254 [17]
327 [10]
1S,2R(+)-Ephedrine-D3 (I$)
N-HFB-O-TMS-
Pri.deriv.
11.36
0.8861
1.1429
179
257 [20]
330 [10]
N-Ethyl amphetamine
N-HFB-
Pri.deriv.
10.33
0.8058
1.0392
268
240 [35]
118 [15]
39
Fenfluramine
N-HFB-
Pri.deriv.
10.12
0.7894
1.0181
268
240 [35]
159 [22]
40
Fenfluramine-D10 (I$)
N-HFB-
Pri.deriv.
10.01
0.7808
1.0070
277
245 [35]
160 [15]
(9)
(8)
Method rev. 1.1.1
(9)
Table 11 continued NIOSH Manual of Analytical Methods (NMAM), Fifth Edition
